hCA/Wnt/β-catenin-IN-1
Based on 1 Customer Validation
hCA/Wnt/β-catenin-IN-1 (Compd 15) is an inhibitor of hCA (Ki: 33.6, 24.1, 6.8 nM for hCA II, hCA IX, hCA XII). hCA/Wnt/β-catenin-IN-1 reduces P-gp activity. hCA/Wnt/β-catenin-IN-1 also inhibits Wnt/β-catenin signaling pathway. hCA/Wnt/β-catenin-IN-1 inhibits cancer cell viability, including the NCI/ADR-RES DOX-resistant cell line.
For research use only. We do not sell to patients.
- Purity: 99.96%
- CAS No.: 3032826-63-1
- Formula: C26H24N2O6S
- Molecular Weight:492.54
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HCT-116 | IC50 |
17 μM
Compound: 15
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Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth measured after 48 to 72 hrs in presence of 5-fluorouracil by MTT assay
Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth measured after 48 to 72 hrs in presence of 5-fluorouracil by MTT assay
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[PMID: 37902628] |
| HCT-116 | IC50 |
8.7 μM
Compound: 15
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Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth measured after 48 to 72 hrs by MTT assay
Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth measured after 48 to 72 hrs by MTT assay
|
[PMID: 37902628] |
| MCF7 | IC50 |
1.9 μM
Compound: 15
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Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth measured after 48 hrs by sulforhodamine B assay
Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth measured after 48 hrs by sulforhodamine B assay
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[PMID: 37902628] |
| NCI/ADR-RES | IC50 |
2.1 μM
Compound: 15
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Antiproliferative activity against human NCI/ADR-RES cells assessed as inhibition of cell growth measured after 48 hrs by sulforhodamine B assay
Antiproliferative activity against human NCI/ADR-RES cells assessed as inhibition of cell growth measured after 48 hrs by sulforhodamine B assay
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[PMID: 37902628] |
| OVCAR-8 | IC50 |
1.9 μM
Compound: 15
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Antiproliferative activity against human OVCAR-8 cells assessed as inhibition of cell growth measured after 48 hrs by sulforhodamine B assay
Antiproliferative activity against human OVCAR-8 cells assessed as inhibition of cell growth measured after 48 hrs by sulforhodamine B assay
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[PMID: 37902628] |
| SW480 | IC50 |
17.7 μM
Compound: 15
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Antiproliferative activity against human SW480 cells assessed as inhibition of cell growth measured after 48 to 72 hrs by XTT assay
Antiproliferative activity against human SW480 cells assessed as inhibition of cell growth measured after 48 to 72 hrs by XTT assay
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[PMID: 37902628] |
| SW480 | IC50 |
42.9 μM
Compound: 15
|
Antiproliferative activity against human SW480 cells assessed as inhibition of cell growth measured after 48 to 72 hrs in presence of 5-fluorouracil by XTT assay
Antiproliferative activity against human SW480 cells assessed as inhibition of cell growth measured after 48 to 72 hrs in presence of 5-fluorouracil by XTT assay
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[PMID: 37902628] |
| SW-620 | IC50 |
23.8 μM
Compound: 15
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Antiproliferative activity against human SW620 cells assessed as inhibition of cell growth measured after 48 to 72 hrs by XTT assay
Antiproliferative activity against human SW620 cells assessed as inhibition of cell growth measured after 48 to 72 hrs by XTT assay
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[PMID: 37902628] |
| SW-620 | IC50 |
37.3 μM
Compound: 15
|
Antiproliferative activity against human SW620 cells assessed as inhibition of cell growth measured after 48 to 72 hrs in presence of 5-fluorouracil by XTT assay
Antiproliferative activity against human SW620 cells assessed as inhibition of cell growth measured after 48 to 72 hrs in presence of 5-fluorouracil by XTT assay
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[PMID: 37902628] |
Chemical Information
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CAS No. 3032826-63-1
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Appearance Solid
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Molecular Weight 492.54
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Formula C26H24N2O6S
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Color White to off-white
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SMILES
O=S(C1=CC=C(N2C=C(C3=CC=CC=C3)C(C(C4=CC(OC)=C(OC)C(OC)=C4)=O)=C2)C=C1)(N)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 125 mg/mL (253.79 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (277 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.0303 mL | 10.1515 mL | 20.3029 mL | 50.7573 mL |
| 5 mM | 0.4061 mL | 2.0303 mL | 4.0606 mL | 10.1515 mL | |
| 10 mM | 0.2030 mL | 1.0151 mL | 2.0303 mL | 5.0757 mL | |
| 15 mM | 0.1354 mL | 0.6768 mL | 1.3535 mL | 3.3838 mL | |
| 20 mM | 0.1015 mL | 0.5076 mL | 1.0151 mL | 2.5379 mL | |
| 25 mM | 0.0812 mL | 0.4061 mL | 0.8121 mL | 2.0303 mL | |
| 30 mM | 0.0677 mL | 0.3384 mL | 0.6768 mL | 1.6919 mL | |
| 40 mM | 0.0508 mL | 0.2538 mL | 0.5076 mL | 1.2689 mL | |
| 50 mM | 0.0406 mL | 0.2030 mL | 0.4061 mL | 1.0151 mL | |
| 60 mM | 0.0338 mL | 0.1692 mL | 0.3384 mL | 0.8460 mL | |
| 80 mM | 0.0254 mL | 0.1269 mL | 0.2538 mL | 0.6345 mL | |
| 100 mM | 0.0203 mL | 0.1015 mL | 0.2030 mL | 0.5076 mL |
hCA/Wnt/β-catenin-IN-1 Related Classifications
HY-155391 Related Classifications
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