500-05-0
Chemical Structure
Coumalic acid
- CAS. Nr.: 500-05-0
- Formula:C6H4O4
- Molecular Weight:140.09
IUPAC Name: 2-oxo-2H-pyran-5-carboxylic acid
InChIKey: ORGPJDKNYMVLFL-UHFFFAOYSA-N
SMILES: O=C(O)C(C=C1)=COC1=O
Biological Activity: Coumalic acid is an inhibitor of human carbonic anhydrase (hCA) (KI = 0.073 μM for hCA IX; KI = 0.083 μM for hCA XII). Coumalic acid is a valuable platform compound which can be prepared from malic acid. Coumalic acid can be used in the flavorings, fragrances and cosmetics industries, as polymer components, and pharmaceutical scaffolds. Coumalic acid displays antibronchial and antimalarial activity[1][2].
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Coumalic acid | 97.65% | Coumalic acid is an inhibitor of human carbonic anhydrase (hCA) (KI = 0.073 μM for hCA IX; KI = 0.083 μM for hCA XII). Coumalic acid is a valuable platform compound which can be prepared from malic acid. Coumalic acid can be used in the flavorings, fragrances and cosmetics industries, as polymer components, and pharmaceutical scaffolds. Coumalic acid displays antibronchial and antimalarial activity. | ||||||||||||||||||||
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- [1]. Smith LK, et, al. Flow synthesis of coumalic acid and its derivatization. Department of Chemistry. 2018, 3: 722-732.
- [2]. Pontecorvi, V., et al., (2022). Novel Insights on Human Carbonic Anhydrase Inhibitors Based on Coumalic Acid: Design, Synthesis, Molecular Modeling Investigation, and Biological Studies. International journal of molecular sciences, 23(14), 7950. [Content Brief]
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