Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
14 Results for "
hCE2
" in MedChemExpress (MCE) Product Catalog:
Products (14)
14 Results for "hCE2" in MCE Product Catalog:
2
Category:
Monophenols Leguminosae Phenols Psoralea corylifolia L. Plants Disease Research Fields Cancer
Target:
Cat. No.: HY-N1377
CAS No.: 10176-66-6
Synonyms: Lysionotin
Cat. No.: HY-N3474
CAS No.: 94805-83-1
Category:
Flavonols other families Flavonoids Other Diseases Phenols Polyphenols Plants Disease Research Fields
Target:
Cat. No.: HY-N0855
CAS No.: 155521-46-3
Synonyms: Alisol-G; 25-Anhydroalisol A
Category:
Triterpenes Alisma plantago-aquatica Linn. Terpenoids Other Diseases Plants Alismataceae Disease Research Fields
Target:
Cat. No.: HY-N3413
CAS No.: 254886-77-6
Cat. No.: HY-N0235R
CAS No.: 10309-37-2
Synonyms: (S)-(+)-Bakuchiol (Standard)
Cat. No.: HY-N3921
CAS No.: 126716-36-7
Category:
Flavonoids Leguminosae Plants Disease Research Fields Glycyrrhiza uralensis Fisch. Cancer Isoflavones
Target:
Cat. No.: HY-N1377R
CAS No.: 10176-66-6
Synonyms: Lysionotin (Standard)
Category:
other families Flavonoids Flavones Phenols Polyphenols Plants
Cat. No.: HY-155228
Target:
Research Areas:
hCES2A-IN-2 (Compound 44) is an orally active human carboxylesterase 2 (hCES2A) inhibitor (IC50: 5.02 μM). hCES2A-IN-2 improves Irinotecan (HY-16562)-induced delayed diarrhea .
Cat. No.: HY-147915
CAS No.: 2416220-53-4
Research Areas:
Benz-AP is a potent photosensitizer. Benz-AP produces singlet oxygen, with a negative correlation with hCES2 (Human carboxylesterase 2) activity. Benz-AP displays a higher photocytotoxicity potency in cancer cells under low hCES2 environments. Upon TPE (Two-photon excitation), Benz-AP produces ROS and kills cancer cells and tumor spheroids .
Cat. No.: HY-176465
CAS No.: 3037959-47-7
Target:
Research Areas:
CES2A-IN-3 (Compound 9d) is a potent serine-targeting covalent human carboxylesterase 2A (hCES2A) inhibitor with an IC50 value of 0.12 nM. CES2A-IN-3 is promising for research of diarrhea and ulcerative colitis .
Cat. No.: HY-182517
CAS No.: 2225980-49-2
Target:
Research Areas:
AG1529 is a TRPV1 inhibitor and capsaicinoid-based soft agent with a human TRPV1 IC50 of 0.9-0.93 μM. AG1529 reversibly blocks capsaicin-evoked TRPV1 activation, binds to the TRPV1 capsaicin binding site, moderately affects pH-induced TRPV1 gating, and does not alter voltage- or heat-mediated TRPV1 responses. AG1529 suppresses TRPV1-mediated neuronal excitability, reduces capsaicin- and pH-evoked neuronal firing, abolishes histaminergic and inflammation-mediated TRPV1 sensitization. AG1529 exhibits anti-nociceptive and antipruritic effects, attenuates in vivo hyperalgesia and pruritus, dose-dependently reduces acute histaminergic itch in rodents, and mildly blocks hTRPA1 and hTRPM8 channel activity. AG1529 undergoes hydrolysis and dermal deactivation, minimizes TRPV1-associated side reactions, does not evoke capsaicin-like burning sensation, and does not disrupt physiological thermal regulation. AG1529 can be used for the research of inflammatory cutaneous nociception and acute histaminergic pruritus [2].
- 1
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
