254886-77-6
254886-77-6
Chemical Structure
Kushenol X
- CAS No.: 254886-77-6
- Formula:C25H28O7
- Molecular Weight:440.49
IUPAC Name: (2R,3R)-2-(2,4-dihydroxyphenyl)-3,5,7-trihydroxy-8-((R)-5-methyl-2-(prop-1-en-2-yl)hex-4-en-1-yl)chroman-4-one
InChIKey: ZJRPDIPXWGIHRB-HVVPNVAPSA-N
SMILES: CC([C@H](C/C=C(C)/C)CC(C(O)=C1)=C(O[C@H](C(C=CC(O)=C2)=C2O)[C@H]3O)C(C3=O)=C1O)=C
Biological Activity: Kushenol X, a flavonoid compound isolated from the roots of Sophora flavescens. Kushenol X is a potent β-glucuronidase and human carboxylesterase 2 (hCE2) inhibitor with IC50s of 2.07 μM and 3.05 μM, respectively[1][2].
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Kushenol X | 97.0% | Kushenol X, a flavonoid compound isolated from the roots of Sophora flavescens. Kushenol X is a potent β-glucuronidase and human carboxylesterase 2 (hCE2) inhibitor with IC50s of 2.07 μM and 3.05 μM, respectively. | ||||||||||||||||||||
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References
- [1]. Cheng-Peng Sun, et al. The study of inhibitory effect of natural flavonoids toward β-glucuronidase and interaction of flavonoids with β-glucuronidase. Int J Biol Macromol. 2020 Jan 15;143:349-358. [Content Brief]
- [2]. Sha-Sha Song, et al. Flavonoids as human carboxylesterase 2 inhibitors: Inhibition potentials and molecular docking simulations. Int J Biol Macromol. 2019 Jun 15;131:201-208. [Content Brief]
Keywords
