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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
19 Results for "
human ErbB2 receptor
" in MedChemExpress (MCE) Product Catalog:
Products (19)
19 Results for "human ErbB2 receptor" in MCE Product Catalog:
1
1 Cited Publications
Cat. No.: HY-P74177
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: EGFR; Epidermal Growth Factor receptor Variant EX12_14del; Prev. ErbB; Cell Proliferation-Inducing Protein 61; ErbB1; Cell Growth Inhibiting Protein 40; ERRP; receptor Protein-Tyrosine Kinase; receptor Tyrosine-Protein Kinase ErbB-1; Alternative Protein EGFR; Erb-B2 receptor Tyrosine Kinase 1; Epidermal Growth Factor; Proto-Oncogene C-ErbB-1; EGFR VIII; HER1; NISBD2; Epidermal Growth Factor receptor (Avian Erythroblastic Leukemia Viral (V-Erb-B) Oncogene Homolog); NNCIS; Erythroblastic Leukemia Viral (V-Erb-B) Oncogene Homolog (Avian); PIG61; Avian Erythroblastic Leukemia Viral (V-Erb-B) Oncogene Homolog; MENA; Epidermal Growth Factor receptor Tyrosine Kinase Domain; Epidermal Growth Factor receptor; Epidermal Growth Factor receptor Variant EX12_15del
Species:
Human
Source:
HEK293
1
1 Cited Publications
Cat. No.: HY-P80116
Synonyms: Avian erythroblastic leukemia viral (v erb b) oncogene homolog antibody;
Cell growth inhibiting protein 40 antibody;
Cell proliferation inducing protein 61 antibody;
EGF R antibody;
EGFR antibody;
EGFR_human antibody;
Epidermal growth factor receptor (avian erythroblastic leukemia viral (v erb b) oncogene homolog) antibody;
Epidermal growth factor receptor antibody;
erb-b2 receptor tyrosine kinase 1 antibody;
ErbB antibody;
ErbB1 antibody;
Errp antibody;
HER1 antibody;
mENA antibody;
NISBD2 antibody;
Oncogen ErbB antibody;
PIG61 antibody;
Proto-oncogene c-ErbB-1 antibody;
receptor tyrosine protein kinase ErbB 1 antibody;
receptor tyrosine-protein kinase ErbB-1 antibody;
SA7 antibody;
Species antigen 7 antibody;
Urogastrone antibody;
v-erb-b Avian erythroblastic leukemia viral oncogen homolog antibody;
wa2 antibody;
Wa5 antibody
Research Areas:
PD 174265 is a highly selective, reversible EGFR/ErbB2 tyrosine kinase inhibitor (IC50=0.45 nM) and cell differentiation inducer. By blocking receptor autophosphorylation and the downstream ERK signaling pathway (with an IC50 of 0.45 μM for full-length ERK), PD 174265 effectively inhibits tumor growth and exhibits antitumor activity without obvious toxicity in in vivo models. PD 174265 drives oligodendrocyte precursor cells to switch from a proliferative state to a differentiated state, significantly upregulates the expression of myelin proteins such as CNP, PLP and MBP, and induces neurite branching. PD 174265 shows no inhibitory effect on other kinases including insulin, PDGF and basic FGF receptors, and serves as a crucial tool molecule for investigating the treatment of human epidermoid carcinoma and the mechanism of myelin repair in multiple sclerosis .
Cat. No.: HY-E70715
The erbB family comprises 4 structurally related receptors: ErbB1 (EGFR), ErbB2 (HER2-neu), ErbB3 and ErbB4. On ligand stimulation, the receptor forms either homodimers or heterodimers, which activate their cytoplasmic domain. ERBB2 775YVMA776 Recombinant Human Active Protein Kinase is a recombinant ERBB2 775YVMA776 protein that can be used to study ERBB2 775YVMA776-related functions .
Cat. No.: HY-P991979
Cat. No.: HY-L074
3,382 compounds
Breast cancer is the most frequent cancer among women, impacting 2.1 million women each year, and also causes the greatest number of cancer-related deaths among women. Surgery is usually the first type of treatment for breast cancer, which is usually followed by chemotherapy or radiotherapy or, in some cases, hormone or targeted therapies, especially for metastatic breast cancer (MBC).
Breast cancer is a heterogeneous disease, which is categorized into 3 major subtypes based on the presence or absence of molecular markers for estrogen or progesterone receptors and human epidermal growth factor 2 (ERBB2; formerly HER2): hormone receptor positive/ERBB2 negative (70% of patients), ERBB2 positive (15%-20%), and triple-negative (tumors lacking all 3 standard molecular markers; 15%). Different intrinsic subtypes exhibit different tumor behavior with different prognoses, and may require specific targeted therapies to maximize treatment effectiveness. Otherwise, some signaling pathways also play important roles in the development of breast cancer, such as NF-κB Signaling Pathway, TGF-beta Signaling Pathway, PI3K/AKT/mTOR signaling pathway and Notch Signaling Pathway. These signaling pathways offer ideal targets for development of new targeted therapies for breast cancer.
MCE supplies a unique collection of 3,382 compounds with identified and potential anti-breast cancer activity. MCE Anti-Breast Cancer Compound Library is a useful tool for anti-breast cancer drugs screening.
Cat. No.: HY-P70254
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: ErbB2; P185ErbB2; Prev. NGL; V-Erb-B2 Avian Erythroblastic Leukemia Viral Oncogene Homolog 2 (Neuro/Glioblastoma Derived Oncogene Homolog); HER2; V-Erb-B2 Erythroblastic Leukemia Viral Oncogene Homolog 2, Neuro/Glioblastoma Derived Oncogene Homolog; NEU; V-Erb-B2 Avian Erythroblastic Leukemia Viral Oncoprotein 2 Isoform C; receptor Tyrosine-Protein Kinase ErbB-2; V-Erb-B2 Avian Erythroblastic Leukemia Viral Oncoprotein 2; Proto-Oncogene C-ErbB-2; Neuroblastoma/Glioblastoma Derived Oncogene Homolog; Proto-Oncogene Neu; receptor Tyrosine-Protein Kinase ErbB-2 Variant; P185(ErbB2); Truncated HER2 Splice Variant P100; C-ERB-2; receptor Protein-Tyrosine Kinase; C-ERB2; Metastatic Lymph Node Gene 19; MLN-19; Alternative Protein ErbB2; HER-2; C-Erb B2/Neu Protein; CD340; CD340 Antigen; V-Erb-B2 Avian Erythroblastic Leukemia Viral Oncogene Homolog 2; HER-2/Neu; Tyrosine Kinase-Type Cell Surface receptor HER2; Herstatin; Neuro/Glioblastoma Derived Oncogene Homolog; VSCN2; human Epidermal Growth Factor receptor 2; MLN19; Metastatic Lymph Node Gene 19 Protein; TKR1; Erb-B2 receptor Tyrosine Kinase 2; MLN 19
Species:
Human
Source:
HEK293
Cat. No.: HY-P73095
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: ErbB2; P185ErbB2; Prev. NGL; V-Erb-B2 Avian Erythroblastic Leukemia Viral Oncogene Homolog 2 (Neuro/Glioblastoma Derived Oncogene Homolog); HER2; V-Erb-B2 Erythroblastic Leukemia Viral Oncogene Homolog 2, Neuro/Glioblastoma Derived Oncogene Homolog; NEU; V-Erb-B2 Avian Erythroblastic Leukemia Viral Oncoprotein 2 Isoform C; receptor Tyrosine-Protein Kinase ErbB-2; V-Erb-B2 Avian Erythroblastic Leukemia Viral Oncoprotein 2; Proto-Oncogene C-ErbB-2; Neuroblastoma/Glioblastoma Derived Oncogene Homolog; Proto-Oncogene Neu; receptor Tyrosine-Protein Kinase ErbB-2 Variant; P185(ErbB2); Truncated HER2 Splice Variant P100; C-ERB-2; receptor Protein-Tyrosine Kinase; C-ERB2; Metastatic Lymph Node Gene 19; MLN-19; Alternative Protein ErbB2; HER-2; C-Erb B2/Neu Protein; CD340; CD340 Antigen; V-Erb-B2 Avian Erythroblastic Leukemia Viral Oncogene Homolog 2; HER-2/Neu; Tyrosine Kinase-Type Cell Surface receptor HER2; Herstatin; Neuro/Glioblastoma Derived Oncogene Homolog; VSCN2; human Epidermal Growth Factor receptor 2; MLN19; Metastatic Lymph Node Gene 19 Protein; TKR1; Erb-B2 receptor Tyrosine Kinase 2; MLN 19
Species:
Human
Source:
HEK293
Cat. No.: HY-P70254U
Purity: ≥ 95%, as determined by reducing SDS-PAGE. ≥ 90%, as determined by MALS.
Synonyms: ErbB2; P185ErbB2; Prev. NGL; V-Erb-B2 Avian Erythroblastic Leukemia Viral Oncogene Homolog 2 (Neuro/Glioblastoma Derived Oncogene Homolog); HER2; V-Erb-B2 Erythroblastic Leukemia Viral Oncogene Homolog 2, Neuro/Glioblastoma Derived Oncogene Homolog; NEU; V-Erb-B2 Avian Erythroblastic Leukemia Viral Oncoprotein 2 Isoform C; receptor Tyrosine-Protein Kinase ErbB-2; V-Erb-B2 Avian Erythroblastic Leukemia Viral Oncoprotein 2; Proto-Oncogene C-ErbB-2; Neuroblastoma/Glioblastoma Derived Oncogene Homolog; Proto-Oncogene Neu; receptor Tyrosine-Protein Kinase ErbB-2 Variant; P185(ErbB2); Truncated HER2 Splice Variant P100; C-ERB-2; receptor Protein-Tyrosine Kinase; C-ERB2; Metastatic Lymph Node Gene 19; MLN-19; Alternative Protein ErbB2; HER-2; C-Erb B2/Neu Protein; CD340; CD340 Antigen; V-Erb-B2 Avian Erythroblastic Leukemia Viral Oncogene Homolog 2; HER-2/Neu; Tyrosine Kinase-Type Cell Surface receptor HER2; Herstatin; Neuro/Glioblastoma Derived Oncogene Homolog; VSCN2; human Epidermal Growth Factor receptor 2; MLN19; Metastatic Lymph Node Gene 19 Protein; TKR1; Erb-B2 receptor Tyrosine Kinase 2; MLN 19
Species:
Human
Source:
HEK293
Cat. No.: HY-P86719
Synonyms: Erb-B2 receptor Tyrosine Kinase 2; NGL; NEU; V-Erb-B2 Avian Erythroblastic Leukemia Viral Oncogene Homolog 2; Tyrosine Kinase-Type Cell Surface receptor HER2; Neuro/Glioblastoma Derived Oncogene Homolog; human Epidermal Growth Factor receptor 2; Metastatic Lymph Node Gene 19 Protein; Proto-Oncogene C-ErbB-2; Proto-Oncogene Neu; EC 2.7.10.1; P185ErbB2; MLN 19; V-Erb-B2 Avian Erythroblastic Leukemia Viral Oncogene Homolog 2; V-Erb-B2 Erythroblastic Leukemia Viral Oncogene Homolog 2, Neuro/Glioblastoma Derived Oncogene Homolog; V-Erb-B2 Avian Erythroblastic Leukemia Viral Oncoprotein 2; Neuroblastoma/Glioblastoma Derived Oncogene Homolog; receptor Tyrosine-Protein Kinase ErbB-2; C-Erb B2/Neu Protein; CD340 Antigen; Herstatin; EC 2.7.10; CD340; HER-2; MLN19; TKR1;
Cat. No.: HY-P86719A
Synonyms: Erb-B2 receptor Tyrosine Kinase 2; NGL; NEU; V-Erb-B2 Avian Erythroblastic Leukemia Viral Oncogene Homolog 2; Tyrosine Kinase-Type Cell Surface receptor HER2; Neuro/Glioblastoma Derived Oncogene Homolog; human Epidermal Growth Factor receptor 2; Metastatic Lymph Node Gene 19 Protein; Proto-Oncogene C-ErbB-2; Proto-Oncogene Neu; EC 2.7.10.1; P185ErbB2; MLN 19; V-Erb-B2 Avian Erythroblastic Leukemia Viral Oncogene Homolog 2; V-Erb-B2 Erythroblastic Leukemia Viral Oncogene Homolog 2, Neuro/Glioblastoma Derived Oncogene Homolog; V-Erb-B2 Avian Erythroblastic Leukemia Viral Oncoprotein 2; Neuroblastoma/Glioblastoma Derived Oncogene Homolog; receptor Tyrosine-Protein Kinase ErbB-2; C-Erb B2/Neu Protein; CD340 Antigen; Herstatin; EC 2.7.10; CD340; HER-2; MLN19; TKR1;
Cat. No.: HY-P70841
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: ErbB4; Proto-Oncogene-Like Protein C-ErbB-4; Erb-B2 receptor Tyrosine Kinase 4; P180ErbB4; HER4; V-Erb-A Avian Erythroblastic Leukemia Viral Oncogene Homolog-Like 4; ALS19; Avian Erythroblastic Leukemia Viral (V-Erb-B2) Oncogene Homolog 4; V-Erb-B2 Avian
Species:
Human
Source:
HEK293
Cat. No.: HY-P73035
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: ErbB4; Proto-Oncogene-Like Protein C-ErbB-4; Erb-B2 receptor Tyrosine Kinase 4; P180ErbB4; HER4; V-Erb-A Avian Erythroblastic Leukemia Viral Oncogene Homolog-Like 4; ALS19; Avian Erythroblastic Leukemia Viral (V-Erb-B2) Oncogene Homolog 4; V-Erb-B2 Avian
Species:
Human
Source:
HEK293
Cat. No.: HY-P700733
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: ErbB4; Proto-Oncogene-Like Protein C-ErbB-4; Erb-B2 receptor Tyrosine Kinase 4; P180ErbB4; HER4; V-Erb-A Avian Erythroblastic Leukemia Viral Oncogene Homolog-Like 4; ALS19; Avian Erythroblastic Leukemia Viral (V-Erb-B2) Oncogene Homolog 4; V-Erb-B2 Avian
Species:
Human
Source:
HEK293
Cat. No.: HY-P78454
Purity: ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: ErbB4; Proto-Oncogene-Like Protein C-ErbB-4; Erb-B2 receptor Tyrosine Kinase 4; P180ErbB4; HER4; V-Erb-A Avian Erythroblastic Leukemia Viral Oncogene Homolog-Like 4; ALS19; Avian Erythroblastic Leukemia Viral (V-Erb-B2) Oncogene Homolog 4; V-Erb-B2 Avian
Species:
Human
Source:
HEK293
Cat. No.: HY-P701234
Purity: ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: ErbB4; Proto-Oncogene-Like Protein C-ErbB-4; Erb-B2 receptor Tyrosine Kinase 4; P180ErbB4; HER4; V-Erb-A Avian Erythroblastic Leukemia Viral Oncogene Homolog-Like 4; ALS19; Avian Erythroblastic Leukemia Viral (V-Erb-B2) Oncogene Homolog 4; V-Erb-B2 Avian
Species:
Human
Source:
HEK293
Cat. No.: HY-P702752
Purity: ≥ 70%, as determined by reducing SDS-PAGE.
Synonyms: ErbB4; Proto-Oncogene-Like Protein C-ErbB-4; Erb-B2 receptor Tyrosine Kinase 4; P180ErbB4; HER4; V-Erb-A Avian Erythroblastic Leukemia Viral Oncogene Homolog-Like 4; ALS19; Avian Erythroblastic Leukemia Viral (V-Erb-B2) Oncogene Homolog 4; V-Erb-B2 Avian
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P703899
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: ErbB4; Proto-Oncogene-Like Protein C-ErbB-4; Erb-B2 receptor Tyrosine Kinase 4; P180ErbB4; HER4; V-Erb-A Avian Erythroblastic Leukemia Viral Oncogene Homolog-Like 4; ALS19; Avian Erythroblastic Leukemia Viral (V-Erb-B2) Oncogene Homolog 4; V-Erb-B2 Avian
Species:
Human;Rhesus Macaque
Source:
HEK293
Cat. No.: HY-P706044
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: ErbB4; Proto-Oncogene-Like Protein C-ErbB-4; Erb-B2 receptor Tyrosine Kinase 4; P180ErbB4; HER4; V-Erb-A Avian Erythroblastic Leukemia Viral Oncogene Homolog-Like 4; ALS19; Avian Erythroblastic Leukemia Viral (V-Erb-B2) Oncogene Homolog 4; V-Erb-B2 Avian
Species:
Human
Source:
Sf9 insect cells
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
