2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK
  3. EGFR
  4. Erbicin

Erbicin is a single-chain antibody against the human ErbB2 receptor. Erbicin specifically binds to ErbB2-positive cells, inhibits receptor autophosphorylation, and is internalized by target cells. Erbicin can be used in breast cancer-related research.

For research use only. We do not sell to patients.

Erbicin

Erbicin Chemical Structure

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Erbicin Related Antibodies

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Description

Erbicin is a single-chain antibody against the human ErbB2 receptor. Erbicin specifically binds to ErbB2-positive cells, inhibits receptor autophosphorylation, and is internalized by target cells. Erbicin can be used in breast cancer-related research[1][2].

Species Reactivity

Human
In Vitro

Erbicin (50-500 nM; 2 h) binds to soluble ErbB2-ECD with a Kd of 50 nM as measured by ELISA, and binds to ErbB2-positive cells with a Kd of 5 nM as measured by ELISA[1].
Erbicin (5-700 nM; 200 s association, 300 s dissociation) binds to soluble ErbB2-ECD, and its Kd is determined as 46.7 nM by SPR kinetic analysis[1].
Erbicin (~3 μM; 400 s intervals) binds to soluble ErbB2-ECD in solution, with a Kd of 77 nM and a binding stoichiometry of 1:1 measured by ITC[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Erbicin Related Antibodies
Gene ID

2064  [NCBI]

Accession
Target

ERBB2/HER2/CD340
Application

ELISA, FACS, Functional assay
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
SMILES

[Erbicin]
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Erbicin Related Classifications

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The dilution calculator equation

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This equation is commonly abbreviated as: C1V1 = C2V2

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ErbicinEGFREpidermal growth factor receptorErbB-1HER1single-chain antibodyhuman ErbB2 receptor
Inhibitorinhibitorinhibit

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