136 Results for "

human IgG2

" in MedChemExpress (MCE) Product Catalog:
Products (136)

136 Results for "human IgG2" in MCE Product Catalog:

11
11 Publications Verification
Cat. No.: HY-K0214

MCE Protein G Agarose, a 4% highly cross-linked agarose reagent coupled with recombinant Protein G, effectively purifies mammalian monoclonal and polyclonal antibodies, such as human IgG3 and rat IgG2a.

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4
4 Cited Publications
Cat. No.: HY-P9925
CAS No.: 1174395-19-7
Synonyms: AMG 827; KHK4827

Target:  

Interleukin Related

Research Areas:  

Inflammation/Immunology Cancer

Brodalumab (AMG 827) is a human anti-interleukin-17-receptor IgG2 monoclonal antibody that can be used for the research of moderate-to-severe plaque psoriasis and rheumatoid arthritis .
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3
3 Cited Publications
Cat. No.: HY-P99444
CAS No.: 2173054-79-8
Synonyms: MSTT 1041A; RG 6149
Astegolimab (MSTT 1041A; RG 6149) is a human IgG2 monoclonal antibody. Astegolimab blocks IL-33 signaling by targeting the IL-33 receptor ST2. Astegolimab reduces p53 expression, mitigates IL33-upregulated SASP factors such as IL1α, IL6 and MCP1. Astegolimab mitigates IL33-increased p-p65/p65 ratio. Astegolimab blocks CM-induced neutrophil extracellular trap (NET) formation. Astegolimab is used in chronic obstructive pulmonary disease (COPD) and myocardial research .
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3
3 Cited Publications
Cat. No.: HY-P99126
Anti-Mouse/Human CD44 Antibody (IM7) is an anti-huamn and mouse CD44 IgG2b monoclonal antibody that recognizes a conserved epitope outside the HA-binding domain of the CD44 molecule. Anti-Mouse/Human CD44 Antibody (IM7) exerts a potent anti-inflammatory effect by inducing the shedding of cell surface CD44, significantly improving symptoms in mice with rheumatoid arthritis without affecting relevant immune responses. Anti-Mouse/Human CD44 Antibody (IM7) can be used for researches on inflammation conditions and cancer such as arthritis and osteosarcoma .
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2
2 Cited Publications
Cat. No.: HY-P99041
CAS No.: 339177-26-3
Synonyms: ABX-EGF

Target:  

EGFR

Research Areas:  

Cancer

Panitumumab (ABX-EGF) is a fully human IgG2 anti-EGFR monoclonal antibody with anti-tumor activity. Panitumumab inhibits tumor cell proliferation, survival and angiogenesis. Panitumumab can be used in the research of cancers, such as colon cancer .
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2
2 Cited Publications
Cat. No.: HY-P99353
CAS No.: 1463459-96-2
Synonyms: Anti-ACVRL1 / ALK-1 Reference Antibody (ascrinvacumab); PF-03446962; GT-90001C

Research Areas:  

Cancer

Ascrinvacumab (PF-03446962) is a human IgG2 monoclonal antibody targets ALK-1. Ascrinvacumab shows binding efficiency with human ALK1 with a Kd value of 7 nM. Ascrinvacumab can be used for the research of hepatocellular carcinoma (HCC) .
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2
2 Cited Publications
Cat. No.: HY-141604
CAS No.: 1182215-65-1
Purity:  99.90%
Synonyms: CDX-011; CR011-vcMMAE
Glembatumumab vedotin (CDX-011) is an ADC comprising a fully human IgG2 monoclonal antibody (CR011) directed against glycoprotein NMB (GPNMB) and conjugated to the potent tubulinbinding cytotoxic agent MMAE via a protease-sensitive vc linker. Glembatumumab vedotin has potent anticancer effects .
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2
2 Cited Publications
Cat. No.: HY-P990587

Target:  

CD28

Research Areas:  

Inflammation/Immunology

FR104 is a humanized antibody expressed in CHO cells that targets CD28. FR104 comprises a huIgG2 heavy chain and a huκ light chain, with a predicted molecular weight (MW) of 145.08 kDa. The isotype control for FR104 can be referenced as Human IgG2 kappa, Isotype Control (HY-P99002).
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2
2 Cited Publications
Cat. No.: HY-P990859

Research Areas:  

Cancer

Anti-CD44 Antibody (Hermes-1) is a kind of rat IgG2a κ chimeric antibody, targeting to human CD44. Anti-CD44 Antibody (Hermes-1) blocks the binding of hyaluronan to CD44. Anti-CD44 Antibody (Hermes-1) restores (Platelet-derived Growth Factor-BB)-induced β-receptor activation and motility in fibroblasts. Anti-CD44 Antibody (Hermes-1) causes partial loss of the anti-aging effect of hyaluronic .
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1
1 Cited Publications
Cat. No.: HY-P99205
CAS No.: 1020264-78-1

Target:  

ADC Antibodies

Research Areas:  

Cancer

Glembatumumab is a fully human IgG2 monoclonal antibody directed against the extracellular structural domain of GPNMB expressed in human breast cancer and melanoma. Glembatumumab can be coupled to the microtubule inhibitor monomethyl auristatin E to form glembatumumab vedotin. Glembatumumab vedotin is an antibody-agent coupling (ADC) with antitumor activity .
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1
1 Cited Publications
Cat. No.: HY-P9974
CAS No.: 1345009-45-1
Synonyms: OMP-18R5

Target:  

Wnt

Research Areas:  

Cancer

Vantictumab (OMP-18R5) is a fully human IgG2 monoclonal antibody. Vantictumab inhibits Wnt pathway signaling by binding to FZD1/2/5/7/8 receptors. Vantictumab can be studied against cancers through direct actions on tumor cells, including CSCs, and effects on the stroma, such as metastatic HER2-negative breast cancer and metastatic pancreatic adenocarcinoma .
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1
1 Cited Publications
Cat. No.: HY-P99414
CAS No.: 1523164-68-2
Synonyms: AMG 557
Prezalumab (AMG 557) is a humanized IgG2 monoclonal antibody targeting ICOSL. Prezalumab inhibits T cell activation and related immune responses by binding to ICOSL and blocking the interaction between ICOS and ICOSL. Prezalumab can be used in the research of autoimmune diseases and inflammatory diseases such as systemic lupus erythematosus. Recommend Isotype Controls: Human IgG2 kappa, Isotype Control (HY-P99002) .
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1
1 Cited Publications
Cat. No.: HY-P99411
CAS No.: 2098790-40-8
Synonyms: SHP647

Target:  

Integrin

Research Areas:  

Inflammation/Immunology

Ontamalimab (SHP647) is a fully-human IgG2 monoclonal antibody targeting mucosal addressin cell adhesion molecule-1 (MAdCAM-1). Ontamalimab can be used for the research of Crohn's disease .
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1
1 Cited Publications
Cat. No.: HY-P990010
CAS No.: 2609642-90-0
Synonyms: IXT-M200

Target:  

Inhibitory Antibodies

Research Areas:  

Cancer

Devextinetug (IXT-M200) is a chimeric anti-methamphetamine, human-derived IgG2κ antibody .
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1
1 Cited Publications
Cat. No.: HY-P990133

Target:  

TNF Receptor

Research Areas:  

Inflammation/Immunology

Anti-Monkey/Human CD40L/CD154 Antibody (5C8) is a mouse-derived IgG2a type antibody inhibitor, targeting to monkey/human CD40L/CD154. Anti-Monkey/Human CD40L/CD154 Antibody (5C8) blocks the interactionbetween CD154 and CD40. Anti-Monkey/Human CD40L/CD154 Antibody (5C8) can be used for the researches of inflammation and immunology, such as colitis and transplant .
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1
1 Cited Publications
Cat. No.: HY-P990210

Target:  

Interleukin Related

Research Areas:  

Inflammation/Immunology

Anti-Mouse/Human IL-7 Antibody (M25) is an anti-mouse IL-7 IgG2b monoclonal antibody. Anti-Mouse/Human IL-7 Antibody (M25) alleviates inflammation by blocking IL-7 signaling and inhibiting innate lymphoid cells (ILC2s) activation. Anti-Mouse/Human IL-7 Antibody (M25) can reduce the number of B cell precursors. Anti-Mouse/Human IL-7 Antibody (M25) can be used for researches on inflammation conditions such as airway inflammation .
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1 Cited Publications
Cat. No.: HY-P99121

Target:  

Integrin

Research Areas:  

Inflammation/Immunology Cancer

Anti-Mouse/Human CD11b Antibody (M1/70) is an anti-mouse CD11b IgG2b monoclonal antibody. Anti-Mouse/Human CD11b Antibody (M1/70) can significantly inhibit the adhesion between dendritic cells (DCs) and platelets. Anti-Mouse/Human CD11b Antibody (M1/70) can kill ovarian cancer cells and inhibit their migration. Anti-Mouse/Human CD11b Antibody (M1/70) can alleviate renal fibrosis and inflammation. Anti-Mouse/Human CD11b Antibody (M1/70) can be used for researches on inflammation conditions and cancer such as ischemia-reperfusion injury (IRI), thrombotic inflammatory conditions and ovarian cancer .
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Cat. No.: HY-P99366A
CAS No.: 1572943-04-4
Synonyms: AMG 157 (anti-TSLP); MEDI 19929 (anti-TSLP); Tezepelumab-ekko (anti-TSLP)

Target:  

Interleukin Related

Research Areas:  

Inflammation/Immunology

Tezepelumab (anti-TSLP) is human monoclonal antibody (IgG2λ) that binds specifically to TSLP, blocking it from interacting with its heterodimeric receptor. Tezepelumab can be used for the research of severe, uncontrolled asthma .
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Cat. No.: HY-P99002

Target:  

Inhibitory Antibodies

Research Areas:  

Inflammation/Immunology

Human IgG2 kappa, Isotype Control is a human monoclonal antibody serving as an isotype control for human IgG2κ antibodies such as Cepeprubart (HY-P990732) and Ersodetug (HY-P990712). Human IgG2 kappa, Isotype Control can be used in T cell research .
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Cat. No.: HY-P99909
CAS No.: 2408850-14-4
Synonyms: PF-06863135; RN-613

Target:  

TNF Receptor

Research Areas:  

Inflammation/Immunology

Elranatamab (PF-06863135) is an anti-CD3E/TNFRSF17 human IgG2κ monoclonal antibody . Recommend Isotype Controls: Human IgG2 kappa, Isotype Control (HY-P99002).
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