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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
56 Results for "
humanized mice
" in MedChemExpress (MCE) Product Catalog:
Products (56)
56 Results for "humanized mice" in MCE Product Catalog:
4
4 Cited Publications
Cat. No.: HY-P9914
CAS No.: 219685-50-4
Synonyms: Anti-Human C5, humanized Antibody; h5G1.1
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Cardiovascular Disease Infection Neurological Disease Inflammation/Immunology
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Cat. No.: HY-P991272
Synonyms: PF-05230900
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ATR-107 (PF-05230900) is a humanized monoclonal antibody inhibitor that targets the interleukin-21 receptor (IL-21R). The Ka value of ATR-107 is 2-4 nM in cynomolgus monkeys, 16 nM in mice, and 71 nM in rats. ATR-107 can be used in research related to systemic lupus erythematosus and air pouch inflammation .
Synonyms: ABSK021
Pimicotinib (ABSK021) is a selective and orally active CSF1R inhibitor with an IC50 value of 19.48 nM (determined by inhibiting ADP production). Pimicotinib exhibits anti-tumor activity .
Cat. No.: HY-P9983
CAS No.: 166089-32-3
Synonyms: SGN-33; HuM-195; GLK-33 Antibody
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Cat. No.: HY-P990748
CAS No.: 2770858-49-4
Synonyms: SAR443765
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Cat. No.: HY-P9960
CAS No.: 637334-45-3
Synonyms: 2H7; PRO70769; RG1594
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Cat. No.: HY-P99118
CAS No.: 2231029-82-4
Synonyms: HLX 10
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Cat. No.: HY-P991069
CAS No.: 1412901-55-3
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GalNAc-L96 is a conjugate of GalNAc and its ligand L96. When conjugated with the A-rich HCV sequence (H12), GalNAc-L96 binds potently to ASGPR, with a Ki value of 10.4 nM. GalNAc-L96 promotes siRNA delivery to hepatocytes .
Cat. No.: HY-P991584
Cat. No.: HY-P991200
Cat. No.: HY-159098
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dWIZ-1 is an orally active molecular glue and chemical probe targeting the WIZ transcription factor, which based on an IMiD backbone, binding to human WIZ with an affinity of 3.5 μM. dWIZ-1 recruits WIZ to the cereblon-DDB1 complex via its ZF7 domain, thereby triggering proteasome-dependent degradation of WIZ. dWIZ-1 significantly induces fetal hemoglobin expression in erythroblasts while reducing the level of inhibitory H3K9 dimethylation at WIZ binding sites such as the β-globin locus. Meanwhile, dWIZ-1 does not affect the proliferation and differentiation of erythroblasts, and no cytotoxicity is observed in in vitro cells or cynomolgus monkey models. dWIZ-1 serves as a critical tool molecule for investigating the mechanism and underlying pathways of sickle cell disease .
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SUCNR1-IN-1 is an orally active SUCNR1 inhibitor. SUCNR1-IN-1 exhibits inhibitory rates of 23% and 56% against rat and mouse SUCNR1 at 100 μM, respectively. SUCNR1-IN-1 can be used in the research of rheumatoid arthritis .
Cat. No.: HY-P99744
CAS No.: 2254522-19-3
Synonyms: TAK-573
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Cat. No.: HY-P991201
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Cat. No.: HY-P991570
CAS No.: 2378046-35-4
Synonyms: AD5-10; oba-01 Antibody
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PD-1/PD-L1-IN-23 is a potent and orally active inhibitor of PD-1/PD-L1. PD-1/PD-L1-IN-23 is an ester proagent of L7. L7 is a benzo[c][1,2,5]oxadiazole derivative and biologically evaluated as inhibitors of PD-L1. PD-1/PD-L1-IN-23 displays significant antitumor effects in tumor models of syngeneic and PD-L1 humanized mice .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
