Ocrelizumab
Based on 1 Customer Validation
Ocrelizumab (Ocrevus) is a humanized anti-CD20 monoclonal antibody. Ocrelizumab can induce B cell depletion and inhibit multiple sclerosis lesions in mice through antibody dependent cytotoxicity (ADCC).
For research use only. We do not sell to patients.
- Purity: ≥99.0%
- CAS No.: 637334-45-3
- Molecular Weight:145.82 kDa
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
Human IgG1 kappa
Human
CD20/MS4A1
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:HuCD20 mice with chronic DTH-TLS lesions[1].
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Dosage:7.5 mg/kg
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Administration:Subcutaneous injection (s.c.) or intravenous injection (i.v.); once daily; 18 days; initiated on Days 63, 70 and 75 post lesion induction
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Result:Reduced the number of CD19+ cells and MS like lesions in the spleen and lymph nodes of mice.
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Animal Model:C57BL/6 mice [2].
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Dosage:50 μg
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Administration:Intravenous injection (i.v.); repeat administration on days 7, 14, and 21
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Result:Reduced the total CD19+ B cells and CD4, CD8 T cells in the blood, spleen, and LN.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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Human IgG1 kappa
ELISA, FACS, Functional assay
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Immobilized CD20/MS4A1 Protein-VLP, Human (HEK293, HY-P78543) can bind Ocrelizumab. The EC50 for this effect is 19.79 ng/mL. -
Flow Cytometry analysis of Raji cells labelling CD20 (red) with Ocrelizumab (anti-CD20) (HY-P9960). Goat Anti-Human IgG (Alexa Fluor 488) (HY-P83776) at a dilution of 1/200 was used as the secondary antibody. Blue-Human IgG1 kappa (HY-P99001). Black-Unlabelled control, cells without incubation with primary antibody.
Chemical Information
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CAS No. 637334-45-3
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Appearance Liquid
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Molecular Weight 145.82 kDa
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Color Colorless to light yellow
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SMILES
[Ocrelizumab]
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Synonyms
2H7; PRO70769; RG1594
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Shipping
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (260 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)