637334-45-3
637334-45-3
Chemical Structure
Ocrelizumab
Synonym(s): 2H7; PRO70769; RG1594
- CAS No.: 637334-45-3
- Formula:N/A
- Molecular Weight:(145.82 kDa)
SMILES: [Ocrelizumab]
Biological Activity: Ocrelizumab (Ocrevus) is a humanized anti-CD20 monoclonal antibody. Ocrelizumab can induce B cell depletion and inhibit multiple sclerosis lesions in mice through antibody dependent cytotoxicity (ADCC)[1][2].
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Ocrelizumab | ≥99.0% | Ocrelizumab (Ocrevus) is a humanized anti-CD20 monoclonal antibody. Ocrelizumab can induce B cell depletion and inhibit multiple sclerosis lesions in mice through antibody dependent cytotoxicity (ADCC). | ||||||||||||||||||||
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References
- [1]. Torres JB, et al. Distribution and efficacy of ofatumumab and ocrelizumab in humanized CD20 mice following subcutaneous or intravenous administration. Front Immunol. 2022 Jul 28;13:814064. [Content Brief]
- [2]. Schubart A, et al. Effect of Subcutaneous vs Intravenous Chronic Treatment with an Anti-CD20 Antibody on B-, T-and Myeloid Lymphocyte Subsets in Blood, Lymph Nodes and Spleen of C57BL/6 Mice (P2. 410)[J]. Neurology, 2018, 90(15_supplement): P2. 410.
Keywords
