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in-haled

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68

Inhibitors & Agonists

3

Biochemical Assay Reagents

2

Inhibitory Antibodies

1

Natural
Products

6

Isotope-Labeled Compounds

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-13580
    Budesonide
    5+ Cited Publications

    		 Glucocorticoid Receptor ADC Payload Inflammation/Immunology Cancer
    Budesonide, an inhaled glucocortical steroid, is an orally active glucocorticoid receptor agonist. Budesonide decreases the size of lung tumors, reverses DNA hypomethylation and modulates mRNA expression of genes. Budesonide is an anti-inflammatory agent used for asthma .
    Budesonide
  • HY-119708
    Ensifentrine
    1 Publications Verification

    RPL-554

    		 Phosphodiesterase (PDE) Infection Neurological Disease Inflammation/Immunology Cancer
    Ensifentrine (RPL-554) is an inhaled dual inhibitor of PDE3 and PDE4 with IC50s of 0.4 nM and 1479 nM, respectively. Ensifentrine blocks PDE3 and PDE4 enzymes, thereby increasing the levels of cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) in lung cells, dilating the bronchi, and inhibiting the activation and migration of inflammatory cells. Ensifentrine can be used in the research of chronic obstructive pulmonary disease (COPD) .
    Ensifentrine
  • HY-W251428
    Phosphatidylglycerols (egg) sodium salt

    Egg PG

    		 Biochemical Assay Reagents Others
    Phosphatidylglycerols (PG) is a selective inhibitor targeting the TLR4 accessory protein CD14/MD-2 complex, inhibiting LPS or virus (such as RSV)-mediated inflammatory signaling pathways through competitive binding. Phosphatidylglycerols directly bind to viral particles to block infection, inhibit COX-2 expression to reduce the release of inflammatory factors (IL-6, IL-8), and improve oxidative stress by regulating mitochondrial membrane phospholipid remodeling. Phosphatidylglycerols can be taken orally or by inhalation and can be used in the study of chronic inflammatory diseases (such as atherosclerosis) and respiratory viral infections (such as RSV) .
    Phosphatidylglycerols (egg) sodium salt
  • HY-14144
    Aclidinium Bromide
    5 Publications Verification

    LAS 34273; LAS-W 330

    		 mAChR Inflammation/Immunology
    Aclidinium Bromide (LAS 34273; LAS-W 330) is a long-acting, inhaled muscarinic antagonist. Aclidinium Bromide has the potential for chronic obstructive pulmonary disease (COPD) research .
    Aclidinium Bromide
  • HY-112624J
    Dextran T4 (MW 4,000)

    Dextran 4; Dextran D4; Dextran T4(MW 3200-4800)

    		 Bacterial Others
    Dextran 4,000 is a mucus rheology modifier. The dextran molecules in Dextran 4,000 can reduce the cross-link density of mucus through osmotic effects and hydrogen bond substitution, and reduce viscoelasticity and improve the mucociliary/cough clearance index by destroying the DNA-mucin network structure in mucus. Dextran 4,000 has the ability to improve the rheological properties and clearance ability of cystic fibrosis (CF) sputum, and can be used in the study of inhalation therapy or aerosol delivery of mucostatic respiratory diseases. The Dextran series of compounds are also natural polysaccharide drug carriers that can be connected to drugs through covalent bonding methods such as ester bonds, amide bonds or click chemistry, or self-assembled to form carriers such as nanoparticles and hydrogels. Dextran is biodegradable and biocompatible, and can achieve targeted delivery and controlled release of drugs. Dextran derivatives can prolong the half-life of drugs, increase local concentrations, and reduce the activity of immune clearance .
    Dextran T4 (MW 4,000)
  • HY-B0603
    Fluticasone

    		Smo Glucocorticoid Receptor Infection Inflammation/Immunology Endocrinology
    Fluticasone is an inhaled corticosteroid used for respiratory research. Fluticasone is a Smo agonist with an IC50 value of 99 nM. Fluticasone activates Hedgehog signaling and promotes the proliferation of primary neuronal stem or precursor cells .
    Fluticasone
  • HY-109190
    Seralutinib
    2 Publications Verification

    GB002; PK10571

    		 PDGFR c-Fms c-Kit Cardiovascular Disease
    Seralutinib (GB002) is an inhaled PDGFRα and PDGFRβ inhibitor. Seralutinib also targets to CSF1R and c-KIT with IC50s of 8 nM and 14 nM, respectively. Seralutinib (GB002) is used in the study for pulmonary arterial hypertension .
    Seralutinib
  • HY-109163
    Treprostinil palmitil

    inS-1009

    		 Prostaglandin Receptor Inflammation/Immunology Endocrinology
    Treprostinil palmitil is a long-acting inhaled pulmonary vasodilator prodrug of Treprostinil (HY-100441), formulated in a lipid nanoparticle (LNP). Treprostinil palmitil can inhibit pulmonary vascular remodeling induced by Su/Hx challenge in rats. Treprostinil palmitil can induce cough. Treprostinil palmitil demonstrates a sustained presence in the lungs with reduced systemic exposure and prolonged inhibition of hypoxia-induced pulmonary vasoconstriction in vivo. Treprostinil palmitil can be studied in research for pulmonary arterial hypertension and interstitial lung disease .
    Treprostinil palmitil
  • HY-108858
    Dornase alfa
    1 Publications Verification

    rhDNase

    		 DNA/RNA Synthesis Endonuclease Inflammation/Immunology
    Dornase alfa (rhDNase) is a recombinant human deoxyribonuclease I (rhDNase) that can specifically degrade extracellular DNA. Dornase alfa catalyzes the cleavage of DNA released by neutrophils in respiratory mucus, reduces sputum viscosity, thereby improving mucus clearance efficiency, reducing airway obstruction and alleviating inflammatory responses. Dornase alfa can be used to improve lung function (such as FEV_1) in cystic fibrosis (CF), reduce the risk of acute pulmonary exacerbations, and has good in vivo tolerability. Dornase alfa acts locally on the respiratory tract through aerosol inhalation, specifically improving the high viscosity of mucus caused by DNA accumulation and related respiratory symptoms .
    Dornase alfa
  • HY-N2085
    L-Perillaldehyde
    1 Publications Verification

    (S)-(-)-Perillaldehyde; (S)-Perillaldehyde

    		 Environmental Pollutants Neurological Disease
    L-Perillaldehyde is a major component in the essential oil containing in Perillae Herba. Inhalation of L-Perillaldehyde shows antidepressant-like activity through the olfactory nervous function .
    L-Perillaldehyde
  • HY-102038
    PC786
    2 Publications Verification

    		 RSV Infection
    PC786 is an inhaled respiratory syncytial virus (RSV) L protein polymerase inhibitor. PC786 demonstrates potent antiviral activity against RSV-A (IC50 <0.09 to 0.71 nM) and RSV-B (IC50, 1.3 to 50.6 nM) .
    PC786
  • HY-76025S
    1,4-Dibromobenzene-d4

    p-Dibromobenzene-d4

    		 Isotope-Labeled Compounds Inflammation/Immunology
    1,4-Dibromobenzene-d4 is a deuterium labeled 1,4-Dibromobenzene. 1,4-Dibromobenzene is used as a fumigant and as a chemical intermediate for pharmaceuticals. Inhalation exposure gives rise to dizziness and chokingwhereas contact with skin or eye produces inflammation and burning in humans .
    1,4-Dibromobenzene-d4
  • HY-13580S
    Budesonide-d8

    		Glucocorticoid Receptor Inflammation/Immunology Cancer
    Budesonide-d8 is the deuterium labeled Budesonide. Budesonide, an inhaled glucocortical steroid, is an orally active glucocorticoid receptor agonist. Budesonide decreases the size of lung tumors, reverses DNA hypomethylation and modulates mRNA expression of genes. Budesonide is an anti-inflammatory agent used for asthma .
    Budesonide-d8
  • HY-B1112
    Fluorothyl

    Bis(2,2,2-trifluoroethyl) ether; Flurothyl

    		 Biochemical Assay Reagents Others
    Fluorothyl (Flurothyl) is a inhaling volatile liquid.
    Fluorothyl
  • HY-103672
    AZD7624

    		p38 MAPK Autophagy Inflammation/Immunology
    AZD7624 is an inhaled p38 inhibitor, with potent anti-inflammatory activity.
    AZD7624
  • HY-W040269
    Dehydrothio-p-toluidine
    1 Publications Verification

    DHPT

    		 Fluorescent Dye Others
    Dehydrothio-p-toluidine (DHPT) is a chemical intermediate used in dyestuff production. Dehydrothio-p-toluidine shows inhalation toxicity in acute and subchronic conditions .
    Dehydrothio-p-toluidine
  • HY-P99872
    Ecleralimab

    CSJ-117; NVP-CSJ117

    		 Interleukin Related Inflammation/Immunology
    Ecleralimab (CSJ-117; NVP-CSJ117) is a Fab-IgG1-λ2 antibody targeting the thymic stromal lymphopoietin (TSLP). Ecleralimab significantly attenuates allergen-induced airway responses and inflammation. Ecleralimab can be used for the study of inhaled asthma .
    Ecleralimab
  • HY-18060
    Bradanicline

    TC-5619

    		 nAChR Neurological Disease
    Bradanicline (TC-5619) is an orally active agonist of α7 nAChR with moderate blood-brain barrier penetration. Bradanicline exhibits high affinity and subtype selectivity for human α7 nAChR. Bradanicline possesses antitussive activity that depends on sustained receptor binding and activation. Bradanicline requires systemic administration to dose-dependently inhibit cough induced by citric acid, bradykinin and inhaled nicotine. Bradanicline is well tolerated in preclinical studies and is widely used in research related to chronic refractory cough .
    Bradanicline
  • HY-B0629
    Mometasone

    		Glucocorticoid Receptor Metabolic Disease Cancer
    Mometasone is an inhaled glucocorticoid. Mometasone can be used in mild asthma with a low sputum eosinophil level. Mometasone has the potential for the research of chronic hand eczema and rhinosinusitis .
    Mometasone
  • HY-111144
    Abediterol

    AZD0548; LAS100977

    		 Adrenergic Receptor Inflammation/Immunology
    Abediterol (LAS100977) is an inhaled long-acting β2-adrenoceptor agonist (LABA) and can be used for the research of asthma and chronic obstructive pulmonary disease (COPD) .
    Abediterol
  • HY-108243
    AZD5423
    2 Publications Verification

    		 Glucocorticoid Receptor Inflammation/Immunology Endocrinology
    AZD5423 is an inhaled, potent, selective, and non-steroidal glucocorticoid receptor (GR) modulator (SGRM) . AZD5423 effectively reduces allergen-induced responses in subjects with mild allergic asthma .
    AZD5423
  • HY-A0234
    Stepronin
    2 Publications Verification

    Prostenoglycine; TTPG; Tiase

    		 Chloride Channel Endocrinology
    Stepronin (Prostenoglycine) is an orally active expectorant (inhalation administration is preferable to oral administration). Stepronin inhibits airway secretion in vitro by reducing Cl - secretion from epithelial cells and mucus glycoprotein secretion from submucosal glands .
    Stepronin
  • HY-18862
    PF-03715455

    		p38 MAPK Inflammation/Immunology
    PF-03715455 is a potent inhaled p38 MAPK inhibitor. PF-03715455 shows some selectivity for p38α over p38β with respective IC50 values of 0.88 and 23 nM. PF-03715455 potently inhibits LPS-induced TNFα production in human whole blood (IC50=1.7 nM). PF-03715455 has potential for the treatment of COPD (chronic obstructive pulmonary disease) .
    PF-03715455
  • HY-13580R
    Budesonide (Standard)
    5+ Cited Publications

    		 Reference Standards Glucocorticoid Receptor ADC Payload Inflammation/Immunology Cancer
    Budesonide (Standard) is the analytical standard of Budesonide. This product is intended for research and analytical applications. Budesonide, an inhaled glucocortical steroid, is an orally active glucocorticoid receptor agonist. Budesonide decreases the size of lung tumors, reverses DNA hypomethylation and modulates mRNA expression of genes. Budesonide is an anti-inflammatory agent used for asthma .
    Budesonide (Standard)
  • HY-120595
    JNJ-49095397

    RV568

    		 p38 MAPK Src Inflammation/Immunology
    JNJ-49095397 (RV568) is an inhaled narrow-spectrum kinase inhibitor (NSKI) against both the α and γ isoforms of p38 MAPK. JNJ-49095397 also inhibits SRC kinase family, specifically haematopoietic kinase (HCK) JNJ-49095397 shows potent anti-inflammatory effects and can be used for the research of chronic obstructive pulmonary disease (COPD) and asthma .
    JNJ-49095397
  • HY-W250172
    Polyethylene glycol tert-octylphenyl ether X-405 (70% in H2O)

    		Biochemical Assay Reagents Others
    Polyethylene glycol tert-octylphenyl ether X-405 (70% in H2O) is a nonionic surfactant commonly used in a variety of industrial and research applications. Polyethylene glycol tert-octylphenyl ether X-405 (70% in H2O) belongs to the family of polyethylene glycol (PEG) ethers with a hydrophilic head and lipophilic tail and is suitable for use in emulsions, detergents and solubilizers. Polyethylene glycol tert-octylphenyl ether X-405 (70% in H2O) is particularly useful in the study of membrane proteins, where it is used to solubilize and stabilize proteins for structural analysis techniques. It is also used in a variety of other applications, including drug delivery systems, nanotechnology, and diagnostic analysis. Additionally, Polyethylene glycol tert-octylphenyl ether X-405 (70% in H2O) is used in the production of microemulsions, salves and lotions due to its emulsifying and solubilizing properties. However, it can be toxic if ingested or inhaled, so proper handling and safety precautions are required.
    Polyethylene glycol tert-octylphenyl ether X-405 (70% in H2O)
  • HY-122317
    Menthol glucuronide

    		Drug Metabolite Others
    Menthol glucuronide, a metabolite of Menthol (HY-N1369), is a plasma and urine biomarker of acute Menthol inhalation .
    Menthol glucuronide
  • HY-120802
    Navafenterol

    AZD-8871; LAS191351

    		 mAChR Adrenergic Receptor Inflammation/Immunology
    Navafenterol (AZD-8871) is an inhaled dual-acting, potent, selective, and long-lasting M3-antagonist/β2-agonist (MABA) with long-lasting effects and favorable safety profile. The pIC50 is 9.5 for human M3 receptor, and the pEC50 is 9.5 for β2-adrenoceptor. Navafenterol can be used for the research of chronic obstructive pulmonary disease (COPD). Bronchoprotective and antisialagogue effects. Favorable cardiovascular profile .
    Navafenterol
  • HY-W015593
    Methylhexanamine hydrochloride

    		Adrenergic Receptor Cardiovascular Disease
    Methylhexanamine hydrochloride is an aliphatic amine and a vasoconstrictor that can be administered by inhalation to the nasal mucosa to exert its effect as a nasal decongestant .
    Methylhexanamine hydrochloride
  • HY-132849
    Nezulcitinib

    TD-0903

    		 JAK Infection Inflammation/Immunology
    Nezulcitinib (TD-0903) is an inhaled and lung-selective pan-Janus kinase (JAK) inhibitor. Nezulcitinib can be used for the research of COVID-19 associated acute lung injury and impaired oxygenation .
    Nezulcitinib
  • HY-107534
    AG-045572

    		GnRH Receptor Endocrinology
    AG-045572 is a GnRH receptor antagonist with Kis of 6.0 nM and 3.8 nM for human and rat GnRH receptor, respectively. AG-045572 is metabolized by CYP3A and ressuppresses testosterone .
    AG-045572
  • HY-A0225B
    Pirbuterol dihydrochloride

    (±)-Pirbuteroldihydrochloride; ARA 211dihydrochloride

    		 Endogenous Metabolite Cardiovascular Disease
    Pirbuterol ((±)-Pirbuterol) dihydrochloride is a beta 2 adrenergic agonist with bronchodilator activity. Pirbuterol dihydrochloride is comparable in duration of action to albuterol when administered by inhalation. Pirbuterol dihydrochloride demonstrates similar beta 2 selectivity to albuterol in humans.
    Pirbuterol dihydrochloride
  • HY-114732
    Procaterol

    		Adrenergic Receptor Others
    Procaterol is an oral selective β2 adrenergic receptor agonist. Procaterol inhibits eosinophil migration and the release of eosinophil chemotactic factor from BEAS-2B cells through a cyclic AMP-dependent mechanism. Procaterol has a large dose difference existing between the bronchodilator effect and the anabolic effect in rat, can be used for asthma research in athletes .
    Procaterol
  • HY-W017431
    2,5-Dimethylbenzoic acid

    		Drug Metabolite Metabolic Disease
    2,5-Dimethylbenzoic acid is one of the main urinary metabolites of Pseudocumene (1,2,4-trimethylbenzene) in rats. 2,5-Dimethylbenzoic acid can be used to quantitatively determine the inhalation exposure level of Pseudocumene .
    2,5-Dimethylbenzoic acid
  • HY-W742981
    Budesonide-d6

    		Isotope-Labeled Compounds Glucocorticoid Receptor ADC Payload Inflammation/Immunology Cancer
    Budesonide-d6 is deuterium labeled Budesonide. Budesonide, an inhaled glucocortical steroid, is an orally active glucocorticoid receptor agonist. Budesonide decreases the size of lung tumors, reverses DNA hypomethylation and modulates mRNA expression of genes. Budesonide is an anti-inflammatory agent used for asthma .
    Budesonide-d6
  • HY-106983
    GR 250495X

    		Glucocorticoid Receptor Inflammation/Immunology
    GR 250495X is an inhaled glucocorticoid receptor agonist. GR 250495X is designed as a antedrug, which takes effect locally in the lungs but is rapidly metabolized and inactivated in the bloodstream after entering the systemic circulation, thereby minimizing systemic side effects. GR 250495X can be used in asthma research .
    GR 250495X
  • HY-119708S
    Ensifentrine-d6

    RPL-554-d6

    		 Isotope-Labeled Compounds Phosphodiesterase (PDE) Inflammation/Immunology
    Ensifentrine-d6 (RPL-554-d6) is deuterium labeled Ensifentrine. Ensifentrine (RPL-554) is an inhaled first-in-class dual inhibitor of phosphodiesterase 3 (PDE3) and PDE4 with IC50s of 0.4 nM and 1479 nM, respectively. Ensifentrine has bronchoprotective and anti-inflammatory activities. Ensifentrine can be used for chronic obstructive pulmonary disease (COPD) research .
    Ensifentrine-d6
  • HY-159952
    ALK5-IN-84

    		Anaplastic lymphoma kinase (ALK) Cardiovascular Disease Neurological Disease Inflammation/Immunology Cancer
    ALK5-IN-84 (Compound 23) is an ALK5 inhibitor with a pKi value of 9.35 against hALK5. When administered via inhalation, ALK5-IN-84 exhibits significant ALK5 inhibitory activity. ALK5-IN-84 is promising for the development of inhaled ALK5 inhibitors .
    ALK5-IN-84
  • HY-100087
    Budesonide impurity C

    		Glucocorticoid Receptor Inflammation/Immunology Cancer
    Budesonide impurity C is an impurity of Budesonide. Budesonide, an inhaled glucocortical steroid, is an orally active glucocorticoid receptor agonist .
    Budesonide impurity C
  • HY-B1481B
    Isoetharine hydrochloride

    Isoetarine hydrochloride

    		 Adrenergic Receptor Infection
    Isoetharine hydrochloride is selective, short-acting and orally active β-agonist which is widely used as a bronchodilator in the research of inhalation research .
    Isoetharine hydrochloride
  • HY-W181626A
    Tiprenolol hydrochloride

    DU 21445 hydrochloride

    		 5-HT Receptor Cardiovascular Disease
    Tiprenolol hydrochloride is a β-adrenoceptor blocker. Tiprenolol hydrochloride abolished ventricular arrhythmias induced by intravenous epinephrine in dogs receiving halothane inhalation .
    Tiprenolol hydrochloride
  • HY-14786
    Darotropium bromide

    GSK233705

    		 mAChR Neurological Disease Inflammation/Immunology
    Darotropium bromide (GSK233705), a long-acting muscarinic antagonist and an inhaled anticholinergic, can be used for the research of chronic obstructive pulmonary disease (COPD) .
    Darotropium bromide
  • HY-157568S
    Budesonide acid-d8

    		Isotope-Labeled Compounds Others
    Budesonide acid-d8 is a deuterium labeled Budesonide acid. Budesonide acid is an impurity of Budesonide. Budesonide, an inhaled glucocortical steroid, is an orally active glucocorticoid receptor agonist .
    Budesonide acid-d8
  • HY-117024
    Abediterol napadisylate

    AZD0548 napadisylate; LAS100977 napadisylate

    		 Adrenergic Receptor Inflammation/Immunology
    Abediterol napadisylate is an inhaled long-acting β2-adrenoceptor agonist (LABA) and can be used for the research of asthma and chronic obstructive pulmonary disease (COPD) .
    Abediterol napadisylate
  • HY-115871
    PDE4-IN-4

    		Phosphodiesterase (PDE) mAChR Others
    PDE4-IN-4 is a dual M3 (pIC50 = 10.2) antagonist-PDE4 (pIC50 = 8.8) inhibitor for the inhaled research of pulmonary diseases.
    PDE4-IN-4
  • HY-14296
    PF-610355

    		Adrenergic Receptor Inflammation/Immunology
    PF-610355 is a long-acting inhaled β2-adrenoreceptor agonist, with an EC50 of 0.26 nM. PF-610355 has the potential for the study of asthma and COPD .
    PF-610355
  • HY-B0629R
    Mometasone (Standard)

    		Reference Standards Glucocorticoid Receptor Metabolic Disease
    Mometasone (Standard) is the analytical standard of Mometasone. This product is intended for research and analytical applications. Mometasone is an inhaled glucocorticoid. Mometasone can be used in mild asthma with a low sputum eosinophil level. Mometasone has the potential for the research of chronic hand eczema and rhinosinusitis .
    Mometasone (Standard)
  • HY-W039897R
    Methyl α-D-mannopyranoside (Standard)

    α-Methyl-D-mannoside (Standard)

    		 Bacterial Reference Standards Inflammation/Immunology
    Methyl α-D-mannopyranoside (Standard) is the analytical standard of Methyl α-D-mannopyranoside. This product is intended for research and analytical applications. Methyl α-D-mannopyranoside could target macrophages in anti-tuberculosis inhalation therapy[1].
    Methyl α-D-mannopyranoside (Standard)
  • HY-14818B
    Laninamivir TFA

    R 125489 TFA

    		 Influenza Virus Infection
    Laninamivir TFA (R 125489 TFA) is an antiviral compound with inhibitory and prophylactic activity against influenza A and B viruses. Laninamivir TFA is a long-acting neuraminidase inhibitor administered by nasal inhalation. Laninamivir TFA has shown good safety and efficacy in the inhibition of influenza viruses .
    Laninamivir TFA
  • HY-B0603R
    Fluticasone (Standard)

    		Reference Standards Smo Glucocorticoid Receptor Infection Inflammation/Immunology Endocrinology
    Fluticasone (Standard) is the analytical standard of Fluticasone. This product is intended for research and analytical applications. Fluticasone is an inhaled corticosteroid used for respiratory research. Fluticasone is a Smo agonist with an IC50 value of 99 nM. Fluticasone activates Hedgehog signaling and promotes the proliferation of primary neuronal stem or precursor cells .
    Fluticasone (Standard)

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