1. GPCR/G Protein
    Neuronal Signaling
  2. mAChR
  3. Aclidinium Bromide

Aclidinium Bromide (Synonyms: LAS 34273; LAS-W 330)

Cat. No.: HY-14144 Purity: 98.08%
Handling Instructions

Aclidinium Bromide (LAS 34273; LAS-W 330) is a long-acting, inhaled muscarinic antagonist. Aclidinium Bromide has the potential for chronic obstructive pulmonary disease (COPD) research.

For research use only. We do not sell to patients.

Aclidinium Bromide Chemical Structure

Aclidinium Bromide Chemical Structure

CAS No. : 320345-99-1

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Free Sample (0.5-1 mg)   Apply Now  
Solution
10 mM * 1 mL in DMSO USD 75 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 75 In-stock
Estimated Time of Arrival: December 31
Solid
5 mg USD 60 In-stock
Estimated Time of Arrival: December 31
10 mg USD 95 In-stock
Estimated Time of Arrival: December 31
50 mg USD 295 In-stock
Estimated Time of Arrival: December 31
100 mg USD 495 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 5 publication(s) in Google Scholar

Top Publications Citing Use of Products

    Aclidinium Bromide purchased from MCE. Usage Cited in: Oncol Lett. 2018 Nov;16(5):6417-6422.

    Western blotting is used to examine the proteins closely related with apoptosis. Results reveal that after treatment with Aclidinium, the expression of the anti-apoptotic protein, Bcl-2, is decreased while the level of pro-apoptotic protein Bax and active-caspase-3 are increased significantly.
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    Description

    Aclidinium Bromide (LAS 34273; LAS-W 330) is a long-acting, inhaled muscarinic antagonist. Aclidinium Bromide has the potential for chronic obstructive pulmonary disease (COPD) research[1][2][3][4].

    In Vitro

    Preclinically, aclidinium showed potent antagonism of human muscarinic receptors, with a long residence time at M3 receptors and a shorter residence time at M2 receptors, indicating the potential to provide sustained bronchodilation. Aclidinium is rapidly hydrolysed in human plasma, unlike other currently available antimuscarinics including tiotropium. Early clinical studies in healthy subjects have confirmed the low systemic bioavailability and favourable safety profile of single and multiple doses of aclidinium. In a subsequent Phase IIb study, which included 464 patients with moderate to severe COPD, aclidinium displayed long-lasting bronchodilatory activity and was well tolerated.

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Clinical Trial
    Molecular Weight

    564.55

    Formula

    C₂₆H₃₀BrNO₄S₂

    CAS No.
    SMILES

    O=C(O[[email protected]]1C[N+]2(CCCOC3=CC=CC=C3)CCC1CC2)C(C4=CC=CS4)(O)C5=CC=CS5.[Br-]

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : 33.33 mg/mL (59.04 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.7713 mL 8.8566 mL 17.7132 mL
    5 mM 0.3543 mL 1.7713 mL 3.5426 mL
    10 mM 0.1771 mL 0.8857 mL 1.7713 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 2.5 mg/mL (4.43 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

      Solubility: ≥ 2.5 mg/mL (4.43 mM); Clear solution

    • 3.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 2.5 mg/mL (4.43 mM); Clear solution

    *All of the co-solvents are provided by MCE.
    References

    Purity: 98.08%

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    Keywords:

    AclidiniumLAS 34273 LAS-W 330LAS34273LAS-34273mAChRMuscarinic acetylcholine receptorInhibitorinhibitorinhibit

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    Product Name:
    Aclidinium Bromide
    Cat. No.:
    HY-14144
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