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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
133 Results for "
interferon alpha
" in MedChemExpress (MCE) Product Catalog:
Products (133)
133 Results for "interferon alpha" in MCE Product Catalog:
29
29 Publications Verification
Cat. No.: HY-W063968
CAS No.: 691868-88-9
Synonyms: CDM-3008; RO4948191
RO8191 (CDM-3008), an imidazonaphthyridine compound, is an orally active and potent interferon (IFN) receptor agonist. RO8191 directly binds to IFNα/β receptor 2 (IFNAR2) and activates IFN-stimulated genes (ISGs) expression and JAK/STAT phosphorylation. RO8191 shows antiviral activity against both HCV and EMCV with an IC50 of 200 nM for HCV replicon . RO8191 is a cccDNA modulator (CDM) through interferon-like activity and has anti-HBV activity .
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6 Cited Publications
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Sparfosic acid trisodium is a DNA antimetabolite agent and a potent inhibitor of aspartate transcarbamoyl transferase. Aspartate transcarbamoyl transferase catalyzes the second step of de novo pyrimidine biosynthesis. Sparfosic acid trisodium synergistically enhances the cytotoxicity of a combination of 5-fluorouracil (5-FU) and interferon-alpha (IFN) against human colon cancer cell lines .
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6 Cited Publications
Cat. No.: HY-112732
CAS No.: 51321-79-0
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Sparfosic acid, a DNA antimetabolite agent, is a potent inhibitor of aspartate transcarbamoyl transferase, the enzyme catalyzing the second step of de novo pyrimidine biosynthesis. Sparfosic acid synergistically enhances the cytotoxicity of a combination of 5-fluorouracil (5-FU) and interferon-alpha (IFN) against human colon cancer cell lines .
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CpG ODN 10101 (ODN 10101; CPG 10101) is a selective agonist targeting TLR9, a synthetic oligodeoxynucleotide modified with phosphate thioester. CpG ODN 10101 activates B cells and plasmacytoid dendritic cells (pDCs), inducing the production of cytokines and chemokines such as interferon-IFN-α, interferon-inducible protein IP-10, and 2'5'-oligoadenylate synthase (2'5'-OAS), regulating innate immunity and promoting Th1 adaptive immune responses. CpG ODN 10101 also possesses antiviral properties and enhances vaccine immunogenicity, making it suitable as an immunomodulator and vaccine adjuvant for vaccine development in chronic hepatitis C and infectious diseases such as melioidosis, pertussis, and respiratory syncytial virus (RSV) .
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2 Cited Publications
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GSK2245035 is a highly potent and selective intranasal Toll-Like receptor 7 (TLR7) agonist with preferential Type-1 interferon (IFN)-stimulating properties. GSK2245035 has pEC50s of 9.3 and 6.5 for IFNα and TFNα. GSK2245035 effectively suppresses allergen-induced Th2 cytokine production in human peripheral blood cell cultures. GSK2245035 is used for asthma .
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1
1 Cited Publications
Cat. No.: HY-W011890
CAS No.: 38609-97-1
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Cridanimod is a potent progesterone receptor (PR) activator mediated through induction of IFNα and IFNβ expression. Cridanimod is a small-molecule immunomodulator and interferon inducer .
1
1 Cited Publications
Cat. No.: HY-P72243
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: IFN-alpha14; IFN14_HUMAN; IFNA14; interferon alpha 14; interferon alpha H; interferon alpha-14; interferon alpha-H; interferon lambda-2-H; interferon lambda2H ; LeIF H; LeIFH; MGC125756; MGC125757
1
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1
1 Cited Publications
Cat. No.: HY-P700183AF
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: interferon alpha 1a; Ifa; Ifa8; IFNA
1
1
1 Cited Publications
Cat. No.: HY-P73246
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: interferon alpha-2; IFN-alpha-2b; LeIF A; IFNA2; IFNA2A
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Source:
1
1 Cited Publications
Cat. No.: HY-173425
CAS No.: 2912492-05-6
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STING-IN-15 is an orally active STING inhibitor, with an IC50 of 116 nM against h-STING and an IC50 of 96.3 nM against m-STING. STING-IN-15 inhibits the STING signaling pathway in cells, reduces the secretion of IFN-β and IP-10, downregulates the expression of ISG15, ISG56 and TNF-α, and suppresses the phosphorylation of TBK1/IRF3. STING-IN-15 alleviates systemic and renal inflammation induced by STING agonists in mice, reduces tissue damage and the expression of interferon pathway genes, and inhibits spontaneous tissue inflammation in mice. STING-IN-15 can be used for the research of acute kidney injury and autoimmune/inflammatory diseases .
1
1 Cited Publications
Cat. No.: HY-P700169AF
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: Cxcl11; Scyb11C-X-C motif chemokine 11; interferon-inducible T-cell alpha chemoattractant; I-TAC; Small-inducible cytokine B11
1
1 Cited Publications
Cat. No.: HY-P5522A
Synonyms: L-Ala-γ-D-Glu-meso-diaminopimelic acid dihydrochloride
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Cat. No.: HY-P99219
CAS No.: 1006877-41-3
Synonyms: MEDI-545; MDX 1103
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Cat. No.: HY-P99348
CAS No.: 1335098-50-4
Synonyms: Ropeginterferon alfa-2b-njft; PEG-proline-interferon alpha-2b
Cat. No.: HY-P99744
CAS No.: 2254522-19-3
Synonyms: TAK-573
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
