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live mice

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7

Inhibitors & Agonists

2

Fluorescent Dyes

1

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-149766
    PB94

    		HDAC Neurological Disease
    PB94 is a selective HDAC11 inhibitor (IC50=108 nM). PB94 can be radiolabeled as [11C]-PB94 for use in positron emission tomography (PET), as well as brain uptake and metabolic properties in administered live animals. PB94 improves neuropathic pain in mice and could be used to study neurological indications .
    PB94
  • HY-160066
    SYL3C aptamer sodium

    		Transmembrane Glycoprotein Cancer
    SYL3C aptamer sodium is a DNA aptamer that targets epithelial cell adhesion molecule (EpCAM) on the surface of cancer cells. SYL3C aptamer sodium targets a variety of human cancer cell lines including MDA-MB-231, Kato III, HT-29, T47D and SW480. The Kd values of SYL3C aptamer sodium against breast cancer cell line MDA-MB-231 and gastric cancer cell line Kato III are 38 nM and 67 nM, respectively. SYL3C aptamer sodium possesses stability, high binding affinity and selectivity, and can be used for targeted cancer cell imaging and circulating tumor cell detection .
    SYL3C aptamer sodium
  • HY-126850
    4-Epidoxycycline

    		EGFR Cancer
    4-Epidoxycycline is a liver metabolite of the antibiotic doxycycline (doxycycline, HY-N0565) and doesn't have antibiotic properties in mice. 4-Epidoxycycline’s ability to regulate HER2 gene expression in vitro and in live mouse models is similar to that of doxycycline, and it shows comparable high efficacy in tumor tissues, achieving over 95% tumor regression rates .
    4-Epidoxycycline
  • HY-D2988
    BIN-3

    		Fluorescent Dye Bacterial Infection
    BIN-3 is a novel near-infrared fluorescent probe. BIN-3 has excellent biocompatibility, no cytotoxicity, and no hemolysis. BIN-3 can be used for highly sensitive and selective imaging of drug-resistant bacterial infections expressing β-lactam enzymes in live mice .
    BIN-3
  • HY-W783351
    CS790AM

    Coppersensor 790 acetoxymethyl ester

    		 Fluorescent Dye Metabolic Disease
    CS790AM (Coppersensor 790 acetoxymethyl ester) is a cell-permeable, Cu +-targeted near-infrared fluorescent probe (λabs=760 nm, λem=790 nm) applicable to live cells. CS790AM can cross lipophilic cell membranes, and is converted into negatively charged CS790 under the action of intracellular esterases to be retained, thus enabling highly sensitive, reversible "turn-on" detection of labile Cu + pools in live cells and mice. CS790AM possesses excellent biocompatibility and selectivity, avoids interference from other metal ions, shows no obvious toxicity, and can be rapidly cleared. CS790AM allows long-term longitudinal monitoring of individual mice, visualizes copper levels in internal organs and isolated livers, and effectively evaluates abnormal copper accumulation in Wilson's disease models (Atp7b -/-) as well as dynamic changes after chelator treatment. CS790AM can be used for research on Wilson's disease and related copper metabolic disorders .
    CS790AM
  • HY-D3214
    NIR-Cu(Ⅱ)

    		Fluorescent Dye Others
    NIR-Cu (Ⅱ) is a near-infrared fluorescent Cu 2+ probe. NIR-Cu (Ⅱ) enables fluorescence imaging of Cu 2+ in living mice. NIR-Cu (Ⅱ) reduces self-absorption and exhibits minimal photobleaching, thus supporting in vivo imaging applications .
    NIR-Cu(Ⅱ)
  • HY-183710
    CDK9-IN-50

    		CDK Androgen Receptor c-Myc Apoptosis DNA/RNA Synthesis Cancer
    CDK9-IN-50 is a selective and orally active CDK9 inhibitor with an IC50 of 2.2 nM. CDK9-IN-50 targets a distinct CDK9-specific subpocket to disrupt RNA polymerase II Ser2 phosphorylation and downregulate short-lived oncoproteins, including AR-V7 and Myc. CDK9-IN-50 exhibits antiproliferative activity against cancer cells, induces apoptosis and induces tumor growth inhibition in CRPC orthotopic mice models. CDK9-IN-50 can be used for the research of cancer, such as prostate cancer .
    CDK9-IN-50

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