2. Cell Cycle/DNA Damage Epigenetics
  3. HDAC
  4. PB94

PB94 is a selective HDAC11 inhibitor (IC50=108 nM). PB94 can be radiolabeled as [11C]-PB94 for use in positron emission tomography (PET), as well as brain uptake and metabolic properties in administered live animals. PB94 improves neuropathic pain in mice and could be used to study neurological indications.

For research use only. We do not sell to patients.

PB94 Chemical Structure

PB94 Chemical Structure

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Description

PB94 is a selective HDAC11 inhibitor (IC50=108 nM). PB94 can be radiolabeled as [11C]-PB94 for use in positron emission tomography (PET), as well as brain uptake and metabolic properties in administered live animals. PB94 improves neuropathic pain in mice and could be used to study neurological indications[1].

IC50 & Target

IC50: 108 nM (HDAC11)[1]
Molecular Weight

487.59

Formula

C29H33N3O4
SMILES

O=C(C1=CC=C2N(C=CC2=C1)CC3=CC=C(C(OC)=C3)C(NO)=O)NCC45C[C@H](C[C@H](C5)C6)C[C@H]6C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PB94 Related Classifications

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PB94PB 94PB-94HDACHistone deacetylasesPositron Emission Computed TomographyPETInhibitorinhibitorinhibit

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