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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
16 Results for "
mTORC1/2
" in MedChemExpress (MCE) Product Catalog:
Products (16)
16 Results for "mTORC1/2" in MCE Product Catalog:
139
139 Publications Verification
Torin 1 is a potent inhibitor of mTOR with an IC50 of 3 nM. Torin 1 inhibits both mTORC1/2 complexes with IC50 values between 2 and 10 nM. Torin 1 is an effective inducer of autophagy.
26
20
20 Cited Publications
Synonyms: GSK2126458; GSK458
Omipalisib (GSK2126458) is an orally active and highly selective inhibitor of PI3K with Kis of 0.019 nM/0.13 nM/0.024 nM/0.06 nM and 0.18 nM/0.3 nM for p110α/β/δ/γ, mTORC1/2, respectively. Omipalisib has anti-cancer activity [1] .
8
Samotolisib (LY3023414) potently and selectively inhibits class I PI3K isoforms, DNA-PK, and mTORC1/2 with IC50s of 6.07 nM, 77.6 nM, 38 nM, 23.8 nM, 4.24 nM and 165 nM for PI3Kα, PI3Kβ, PI3Kδ, PI3Kγ, DNA-PK and mTOR, respectively. Samotolisib potently inhibits mTORC1/2 at low nanomolar concentrations [1] .
6
6 Cited Publications
Target:
Domaines de recherche:
WAY-600 is a potent, ATP-competitive, and selective mTOR inhibitor with an IC50 of 9 nM for recombinant mTOR enzyme. WAY-600 blocks mTOR complex 1/2 (mTORC1/2) assemble and activation.
4
2
Cat. No.: HY-N2517
CAS No.: 15266-35-0
Category:
Alkaloids Evodia rutaecarpa (Juss.) Benth. Rutaceae Quinoline Alkaloids Plants Disease Research Fields Cancer
Target:
PQR530 is a potent, ATP-competitive, orally bioavailable and brain-penetrant dual pan-PI3K/mTORC1/2 inhibitor, with a subnanomolar Kd toward PI3Kα and mTOR (0.84 and 0.33 nM, respectively). Antitumor activity [1] .
Cat. No.: HY-N0112R
CAS No.: 27200-12-0
Synonyms: Ampelopsin (Standard); Ampeloptin (Standard)
Category:
Flavanonols other families Flavonoids Phenols Polyphenols Plants
Cat. No.: HY-N0112S
Synonyms: Ampelopsin-d4; Ampeloptin-d4
Cat. No.: HY-N0656AR
CAS No.: 7562-61-0
Category:
Target:
Cat. No.: HY-100026R
CAS No.: 1927857-56-4
Target:
Domaines de recherche:
PQR620 (Standard) is the analytical standard of PQR620 (HY-100026). This product is intended for research and analytical applications. PQR620 is an orally bioavailable and selective brain penetrant inhibitor of mTORC1/2 [1].
Cat. No.: HY-10297R
CAS No.: 1086062-66-9
Synonyms: GSK2126458 (Standard); GSK458 (Standard)
Target:
Domaines de recherche:
Omipalisib (Standard) is the analytical standard of Omipalisib (HY-10297). This product is intended for research and analytical applications. Omipalisib (GSK2126458) is an orally active and highly selective inhibitor of PI3K with Kis of 0.019 nM/0.13 nM/0.024 nM/0.06 nM and 0.18 nM/0.3 nM for p110α/β/δ/γ, mTORC1/2, respectively. Omipalisib has anti-cancer activity [1] .
Cat. No.: HY-107365R
CAS No.: 1927857-61-1
Target:
Domaines de recherche:
PQR530 (Standard) is the analytical standard of PQR530 (HY-107365). This product is intended for research and analytical applications. PQR530 is a potent, ATP-competitive, orally bioavailable and brain-penetrant dual pan-PI3K/mTORC1/2 inhibitor, with a subnanomolar Kd toward PI3Kα and mTOR (0.84 and 0.33 nM, respectively). Antitumor activity [1] .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
