27 Results for "

mitoxantrone

" in MedChemExpress (MCE) Product Catalog:
Products (27)

27 Results for "mitoxantrone" in MCE Product Catalog:

48
48 Publications Verification
Cat. No.: HY-13502
CAS No.: 65271-80-9
Purity:  99.58%
Synonyms: Mitozantrone; NSC 301739
Mitoxantrone is a potent topoisomerase II inhibitor. Mitoxantrone also inhibits protein kinase C (PKC) activity with an IC50 of 8.5 μM. Mitoxantrone induces apoptosis of B-CLL (B-chronic lymphocytic leukaemia) cells. Mitoxantrone shows antitumor activity . Mitoxantrone also has anti-orthopoxvirus activity with EC50s of 0.25 μM and and 0.8 μM for cowpox and monkeypox, respectively .
loading...
    loading...
48
48 Publications Verification
Cat. No.: HY-13502A
CAS No.: 70476-82-3
Purity:  99.55%
Synonyms: Mitozantrone dihydrochloride; NSC 301739 dihydrochloride
Mitoxantrone dihydrochloride is a potent topoisomerase II inhibitor. Mitoxantrone dihydrochloride also inhibits protein kinase C (PKC) activity with an IC50 of 8.5 μM. Mitoxantrone dihydrochloride induces apoptosis of B-CLL (B-chronic lymphocytic leukaemia) cells. Mitoxantrone dihydrochloride shows antitumor activity . Mitoxantrone dihydrochloride also has anti-orthopoxvirus activity with EC50s of 0.25 μM and and 0.8 μM for cowpox and monkeypox, respectively .
loading...
    loading...
10
10 Cited Publications
Cat. No.: HY-N2342
CAS No.: 37064-30-5
Synonyms: PCC1
Procyanidin C1 (PCC1), a natural polyphenol with oral activity, causes DNA damage, cell cycle arrest and induces apoptosis. Procyanidin C1 decreases the level of Bcl-2, but enhances BAX, caspase 3 and 9 expression in cancer cells. Procyanidin C1 shows senotherapeutic activity and increases lifespan in mice .
loading...
    loading...
Cat. No.: HY-148702
CAS No.: 1349197-90-5
Purity:  98.37%
di-Pal-MTO is a palm oil-based lipid produced by combining the anticancer agent mitoxantrone (MTO) with palmitoleic acid. When nanoparticles of mono-Pal-MTO and di-Pal-MTO are combined in a molar ratio of 1:1, they show effective siRNA cell delivery and enhance anticancer activity .
loading...
    loading...
Cat. No.: HY-P5391
CAS No.: 717919-61-4
Target:  

BCRP

Research Areas:  

Cancer

LL-37 (17-32) is an ABCG2 inhibitor. LL-37 (17-32) binds to ABCG2, inhibits its transport activity in a non-competitive manner, and downregulates ABCG2 protein expression via lysosomal degradation. LL-37 (17-32) increases the accumulation of Mitoxantrone (HY-13502) in cancer cells overexpressing ABCG2, thereby reversing mitoxantrone resistance. LL-37 (17-32) can be used in the research of multidrug-resistant cancers .
loading...
    loading...
Cat. No.: HY-136450
CAS No.: 100648-13-3
Purity:  98.78%
Synonyms: TCBZ-SO
Target:  

Parasite BCRP

Research Areas:  

Infection Cancer

Triclabendazole sulfoxide (TCBZ-SO) is an orally active ABCG2 inhibitor with antiparasitic activity. Triclabendazole sulfoxide inhibits ABCG2-mediated active efflux and ATPase activity. Triclabendazole sulfoxide increases the intracellular accumulation of Mitoxantrone (HY-13502). Triclabendazole sulfoxide reduces the apical-directed transepithelial transport of Nitrofurantoin and Danofloxacin, while increasing their basolateral-directed transepithelial transport. Triclabendazole sulfoxide elevates the plasma levels of sulfasalazine in wild-type mice. Triclabendazole sulfoxide decreases ABCG2-mediated secretion of Nitrofurantoin into milk in wild-type lactating mice. Triclabendazole sulfoxide can be used in the research of insecticidal agents and cancers such as breast cancer .
loading...
    loading...
Cat. No.: HY-13727
CAS No.: 144510-96-3
Synonyms: BBR 2778 free base
Target:  

Topoisomerase

Research Areas:  

Cancer

Pixantrone (BBR 2778 (free base)), a mitoxantrone analog, is a topoisomerase II inhibitor and DNA intercalator, with anti-tumor activity.
loading...
    loading...
Cat. No.: HY-N2342R
CAS No.: 37064-30-5
Synonyms: PCC1 (Standard)
Procyanidin C1 (Standard) is the analytical standard of Procyanidin C1. This product is intended for research and analytical applications. Procyanidin C1 (PCC1), a natural polyphenol with oral activity, causes DNA damage, cell cycle arrest and induces apoptosis. Procyanidin C1 decreases the level of Bcl-2, but enhances BAX, caspase 3 and 9 expression in cancer cells. Procyanidin C1 shows senotherapeutic activity and increases lifespan in mice .
loading...
    loading...
Cat. No.: HY-13727B
CAS No.: 175989-38-5
Synonyms: BBR 2778 hydrochloride
Target:  

Topoisomerase

Research Areas:  

Cancer

Pixantrone (BBR 2778 (free base)) hydrochloride, a mitoxantrone analog, is a topoisomerase II inhibitor and DNA intercalator, with anti-tumor activity .
loading...
    loading...
Cat. No.: HY-13502B
CAS No.: 70711-41-0
Synonyms: Mitozantrone diacetate; NSC 301739 diacetate
Mitoxantrone diacetate is a potent topoisomerase II inhibitor. Mitoxantrone diacetate also inhibits protein kinase C (PKC) activity with an IC50 of 8.5 μM. Mitoxantrone diacetate induces apoptosis of B-CLL (B-chronic lymphocytic leukaemia) cells. Mitoxantrone diacetate shows antitumor activity . Mitoxantrone diacetate also has anti-orthopoxvirus activity with EC50s of 0.25 μM and and 0.8 μM for cowpox and monkeypox, respectively .
loading...
    loading...
Cat. No.: HY-13502AS
Synonyms: Mitozantrone-d8dihydrochloride; NSC 301739-d8 dihydrochloride
Mitoxantrone-d8 dihydrochloride is deuterated labeled Mitoxantrone dihydrochloride (HY-13502A). Mitoxantrone dihydrochloride is a potent topoisomerase II inhibitor. Mitoxantrone dihydrochloride also inhibits protein kinase C (PKC) activity with an IC50 of 8.5 μM. Mitoxantrone dihydrochloride induces apoptosis of B-CLL (B-chronic lymphocytic leukaemia) cells. Mitoxantrone dihydrochloride shows antitumor activity . Mitoxantrone dihydrochloride also has anti-orthopoxvirus activity with EC50s of 0.25 μM and and 0.8 μM for cowpox and monkeypox, respectively .
loading...
    loading...
Cat. No.: HY-13502AS1
Synonyms: Mitozantrone-d8 hydrochloride; NSC 301739-d8 hydrochloride
Mitoxantrone-d8 (hydrochloride) (Mitozantrone-d8 (hydrochloride)) is deuterium labeled Mitoxantrone (dihydrochloride). Mitoxantrone dihydrochloride is a potent topoisomerase II inhibitor. Mitoxantrone dihydrochloride also inhibits protein kinase C (PKC) activity with an IC50 of 8.5 μM. Mitoxantrone dihydrochloride induces apoptosis of B-CLL (B-chronic lymphocytic leukaemia) cells. Mitoxantrone dihydrochloride shows antitumor activity . Mitoxantrone dihydrochloride also has anti-orthopoxvirus activity with EC50s of 0.25 μM and and 0.8 μM for cowpox and monkeypox, respectively .
loading...
    loading...
Cat. No.: HY-13502AR
CAS No.: 70476-82-3
Synonyms: Mitozantrone dihydrochloride (Standard); NSC 301739 dihydrochloride (Standard)
Mitoxantrone (dihydrochloride) (Standard) is the analytical standard of Mitoxantrone (dihydrochloride). This product is intended for research and analytical applications. Mitoxantrone dihydrochloride is a potent topoisomerase II inhibitor. Mitoxantrone dihydrochloride also inhibits protein kinase C (PKC) activity with an IC50 of 8.5 μM. Mitoxantrone dihydrochloride induces apoptosis of B-CLL (B-chronic lymphocytic leukaemia) cells. Mitoxantrone dihydrochloride shows antitumor activity . Mitoxantrone dihydrochloride also has anti-orthopoxvirus activity with EC50s of 0.25 μM and and 0.8 μM for cowpox and monkeypox, respectively .
loading...
    loading...
Cat. No.: HY-13502R
CAS No.: 65271-80-9
Synonyms: Mitozantrone (Standard); NSC 301739 (Standard)
Mitoxantrone (Standard) is the analytical standard of Mitoxantrone. This product is intended for research and analytical applications. Mitoxantrone is a potent topoisomerase II inhibitor. Mitoxantrone also inhibits protein kinase C (PKC) activity with an IC50 of 8.5 μM. Mitoxantrone induces apoptosis of B-CLL (B-chronic lymphocytic leukaemia) cells. Mitoxantrone shows antitumor activity . Mitoxantrone also has anti-orthopoxvirus activity with EC50s of 0.25 μM and and 0.8 μM for cowpox and monkeypox, respectively .
loading...
    loading...
Cat. No.: HY-13502S
CAS No.: 1189974-82-0
Synonyms: Mitozantrone-d8; NSC 301739-d8
Mitoxantrone-d8 (mitozantrone-d8) is the deuterium labeled Mitoxantrone. Mitoxantrone is a topoisomerase II inhibitor and also inhibits protein kinase C (PKC) activity with an IC50 of 8.5 μM .
loading...
    loading...
Cat. No.: HY-148701
CAS No.: 1349197-89-2
mono-Pal-MTO is a palm oil-based lipid produced by combining the anticancer agent mitoxantrone (MTO) with palmitoleic acid. When nanoparticles of mono-Pal-MTO and di-Pal-MTO are combined in a molar ratio of 1:1, they show effective siRNA cell delivery and enhance anticancer activity .
loading...
    loading...
Cat. No.: HY-122416
CAS No.: 68236-11-3
Synonyms: Lonchocarpol A; Senegalensin
6,8-Diprenylnaringenin (Lonchocarpol A; Senegalensin), a hop prenylflavonoid, is a inhibitor of breast cancer resistance protein (BCRP/ABCG2). 6,8-Diprenylnaringenin inhibits ABCG2-mediated efflux of Mitoxantrone, and 3H-Methotrexate transport (IC50=0.41 μM) in HEK293 cells. 6,8-Diprenylnaringenin exhibits some estrogenicity, but its potency is less than 1% of that of 8-Prenylnaringenin .
loading...
    loading...
Cat. No.: HY-147740
CAS No.: 70492-21-6
Research Areas:  

Cancer

WEHI-150 is a replica of mitoxantrone, is a portent DNA interstrand crosslink
loading...
    loading...
Cat. No.: HY-185372
Synonyms: Liposomal mitoxantrone
Target:  

Liposome Topoisomerase PKC

Research Areas:  

Cancer

Mitoxantrone hydrochloride liposome is a liposome-encapsulated Mitoxantrone hydrochloride (HY-13502A) (a topoisomerase II inhibitor). Compared to regular Mitoxantrone hydrochloride, Mitoxantrone hydrochloride liposome enhances antitumor activity and prolongs drug circulation time in the body.
loading...
    loading...
Cat. No.: HY-169860
CAS No.: 2953730-35-1
Target:  

BCRP

Research Areas:  

Cancer

BCRP-IN-2 has BCRP inhibitory activity and shows even greater inhibition of BCRP after activation by ultraviolet light. BCRP-IN-2 can be a valuable probe for studying the interactions of quinazolinamine derivatives with BCRP, as it stimulates ATP hydrolysis of the BCRP transport protein, increasing the accumulation of mitoxantrone (HY-13502) in H460/MX20 cells with BCRP overexpression .
loading...
    loading...