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murine choroidal neovascularization models

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Inhibitors & Agonists

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Inhibitory Antibodies

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-113040B

    (±)-17(S),18(R)-EETeTr

    Drug Isomer Others
    (±)-(17S,18R)-Epoxyeicosatetraenoic acid ((±)-17 (S),18 (R)-EETeTr) is one of the constituent enantiomers of (±) 17 (18)-EpETE. (±) 17 (18)-EpETE is an active metabolite of the ω-3 fatty acid eicosapentaenoic acid, and also an agonist of sphingosine-1-phosphate receptor 1 (S1P1) .
    (±)-(17S,18R)-Epoxyeicosatetraenoic acid
  • HY-P992151

    LT1002

    LPL Receptor Interleukin Related Cardiovascular Disease Neurological Disease Inflammation/Immunology Cancer
    Sphingomab (LT1002) is a mouse-derived IgG1 κ monoclonal antibody and also an inhibitor targeting S1P, with high affinity for S1P and a Kd value of 0.03 ± 0.002 nM. Sphingomab blocks S1P-mediated IL-8 release in ovarian cancer cells. Sphingomab exhibits anti-angiogenic activity in a mouse model of choroidal neovascularization. Sphingomab reduces peripheral blood lymphocyte counts. Sphingomab can be used in the research of ovarian cancer and age-related macular degeneration .
    Sphingomab

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