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Results for "

norepinephrine uptake

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (17) Adrenergic Receptor (23) Akt (1) Bacterial (4) Biochemical Assay Reagents (1) Cholinesterase (ChE) (4) Dopamine Receptor (10) Dopamine Transporter (8) Drug Metabolite (3) Endogenous Metabolite (1) Histamine Receptor (1) Histone Methyltransferase (1) Isotope-Labeled Compounds (4) mAChR (1) Monoamine Transporter (3) nAChR (2) Potassium Channel (1) Reference Standards (8) Serotonin Transporter (8)
By Research Areas:	Cardiovascular Disease (2) Inflammation/Immunology (3) Metabolic Disease (3) Neurological Disease (46)

By Targets:

5-HT Receptor (17)

Adrenergic Receptor (23)

Akt (1)

Bacterial (4)

Biochemical Assay Reagents (1)

Cholinesterase (ChE) (4)

Dopamine Receptor (10)

Dopamine Transporter (8)

Drug Metabolite (3)

Endogenous Metabolite (1)

Histamine Receptor (1)

Histone Methyltransferase (1)

Isotope-Labeled Compounds (4)

mAChR (1)

Monoamine Transporter (3)

nAChR (2)

Potassium Channel (1)

Reference Standards (8)

Serotonin Transporter (8)

By Research Areas:

Cardiovascular Disease (2)

Inflammation/Immunology (3)

Metabolic Disease (3)

Neurological Disease (46)

Inhibitors & Agonists

Peptides

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-14560C

Reboxetine mesylate 2 Publications Verification FCE20124 mesylate; PNU155950E mesylate	Adrenergic Receptor	Neurological Disease
Reboxetine mesylate (FCE20124 mesylate) is a potent, selective, and specific noradrenaline reuptake inhibitor (NARI) for the research of depression. Reboxetine mesylate inhibits the uptake of norepinephrine, with a K_i of 8 nM .

HY-N0740

Jatrorrhizine chloride 3 Publications Verification	Cholinesterase (ChE) 5-HT Receptor Bacterial	Neurological Disease Inflammation/Immunology
Jatrorrhizine chloride is an alkaloid isolated from?Coptis chinensis with neuroprotective, antimicrobial, antiplasmodial and antioxidant activities . Jatrorrhizine chloride is a potent and orally active inhibitor of?AChE?(IC₅₀=872 nM) over >115-fold selectivity for BuChE . Jatrorrhizine chloride reduces uptake of serotonin (5-HT) and norepinephrine (NE) via inhibition of uptake-2 transporters .

HY-14472

Tesofensine NS-2330	Dopamine Transporter Serotonin Transporter	Metabolic Disease
Tesofensine (NS-2330) is a triple monoamine reuptake inhibitor inducing a potent inhibition of the re-uptake process in the synaptic cleft of the neurotransmitters dopamine (DA; IC₅₀=6.5 nM), norepinephrine (NE;IC₅₀=1.7 nM), and serotonin (5-HT;IC₅₀=11 nM), and with potentials as an anti-obesity agent . Tesofensine is a CNS acting anti-obesity agent .

HY-100637

Hydroxybupropion 1 Publications Verification	Drug Metabolite Adrenergic Receptor nAChR	Neurological Disease
Hydroxybupropion is the major active metabolite of Bupropion. Hydroxybupropion is metabolized by CYP2B6. Bupropion is an atypical antidepressant and smoking-cessation agent. Hydroxybupropion inhibits **norepinephrine uptake with an IC₅₀ value of 1.7 μM. Hydroxybupropion is also a nACh receptor** antagonist .

HY-14542A

Ziprasidone hydrochloride 3 Publications Verification CP-88059 hydrochloride	5-HT Receptor Dopamine Receptor	Neurological Disease
Ziprasidone (CP-88059) hydrochloride is an orally active combined 5-HT and dopamine receptor antagonist . Ziprasidone hydrochloride has affinities for Rat D₂ (K_i=4.8 nM), 5-HT_2A (K_i=0.42 nM) and 5-HT_1A (K_i=3.4 nM) .

HY-108256

Melitracen hydrochloride	5-HT Receptor	Neurological Disease
Melitracen hydrochloride is an orally active biphasic antidepressant and antianxiety agent. Melitracen hydrochloride can inhibit the uptake of Norepinephrine and 5-HT (serotonin) through the presynaptic membrane inducing the increase of monoamine transmitters in synaptic space .

HY-N0749

Jatrorrhizine	Cholinesterase (ChE) 5-HT Receptor Bacterial	Neurological Disease
Jatrorrhizine is an alkaloid isolated from Coptis chinensis with neuroprotective, antimicrobial, antiplasmodial and antioxidant activities . Jatrorrhizine is a potent and orally active inhibitor of AChE (IC₅₀=872 nM) over >115-fold selectivity for BuChE . Jatrorrhizine reduces uptake of serotonin (5-HT) and norepinephrine (NE) via inhibition of uptake-2 transporters .

HY-B1110

Nomifensine 5+ Cited Publications (±)-Nomifensine; Nomifensin	Dopamine Receptor Adrenergic Receptor	Neurological Disease
Nomifensine ((±)-Nomifensine) is a potent norepinephrine (NE) and dopamine (DA) reuptake inhibitor. Nomifensine inhibits uptake of NE, DA and 5-HT in rat brain synaptosomes, with IC₅₀ values of 6.6 nM, 48 nM and 830 nM, and K_i values of 4.7 nM, 26 nM and 4000 nM, respectively. Nomifensine has antidepressant and analgesic effects. Nomifensine is used in neurodegenerative diseases, compound addiction, and pain research .

HY-B1110A

Nomifensine maleate 5+ Cited Publications (±)-Nomifensine maleate; Nomifensin maleate	Dopamine Receptor Adrenergic Receptor	Neurological Disease
Nomifensine ((±)-Nomifensine) maleate is a potent norepinephrine (NE) and dopamine (DA) reuptake inhibitor. Nomifensine maleate inhibits uptake of NE, DA and 5-HT in rat brain synaptosomes, with IC₅₀ values of 6.6 nM, 48 nM and 830 nM, and K_i values of 4.7 nM, 26 nM and 4000 nM, respectively. Nomifensine maleate has antidepressant and analgesic effects. Nomifensine maleate is used in neurodegenerative diseases, compound addiction, and pain research .

HY-B0952

2-Aminoheptane 1 Publications Verification Tuaminoheptane	Adrenergic Receptor	Neurological Disease
2-Aminoheptane (Tuaminoheptane) is a norepinephrine transporter inhibitor. 2-Aminoheptane binds to norepinephrine transporter via ionic and hydrophobic interactions to block norepinephrine uptake. 2-Aminoheptane deactivates ω-TAmla enzyme, reduces recombinant whole cell stability, and acts as an amino group donor substrate for ω-TA and ω-TAmla enzymes. 2-Aminoheptane can be used in research on depression and Alzheimer's disease .

HY-N0749A

Jatrorrhizine hydroxide 3 Publications Verification	Cholinesterase (ChE) 5-HT Receptor Bacterial	Neurological Disease Inflammation/Immunology
Jatrorrhizine hydroxide is an alkaloid isolated from Coptis chinensis with neuroprotective, antimicrobial, antiplasmodial and antioxidant activities . Jatrorrhizine hydroxide is a potent and orally active inhibitor of AChE (IC₅₀=872 nM) over >115-fold selectivity for BuChE . Jatrorrhizine hydroxide reduces uptake of serotonin (5-HT) and norepinephrine (NE) via inhibition of uptake-2 transporters .

HY-U00050

(E)-10-Hydroxynortriptyline E-10-OH-NT	Drug Metabolite Adrenergic Receptor mAChR	Neurological Disease
(E)-10-Hydroxynortriptyline (E-10-OH-NT) is a blood-brain barrier-permeable *norepinephrine* uptake inhibitor. (E)-10-Hydroxynortriptyline effectively promotes central norepinephrine neuronal transmission, with little interindividual variation in in vivo potency. (E)-10-Hydroxynortriptyline has low affinity for muscarinic receptors, exhibits only extremely weak anticholinergic activity, and does not inhibit salivary secretion. (E)-10-Hydroxynortriptyline can be used in studies related to depression .

HY-W685943

Heptaminol	Adrenergic Receptor	Cardiovascular Disease Neurological Disease
Heptaminol is a fatty amine with pressor properties and a potential antihypotension agent. Heptaminol is also a competitive inhibitor of norepinephrine uptake and an inhibitor of nicotine-induced catecholamine release (IC₅₀: 650 μM). Heptaminol does not inhibit norepinephrine release induced by 59 mM K ⁺ but rather inhibits high-affinity Na ⁺-dependent norepinephrine uptake .

HY-116211

Amfonelic acid WIN-25978	Biochemical Assay Reagents	Neurological Disease
Amfonelic acid (WIN-25978) is a highly selective dopamine reuptake inhibitor. Amfonelic acid interferes with the in vitro neuronal uptake of norepinephrine in the iris of rats, but does not alter the concentrations of norepinephrine or dopamine in the whole mouse brain. Amfonelic acid can be used as a pharmacological tool to study the brain reward system, dopamine pathway and dopamine transporter .

HY-18610A

Diclofensine Ro 8-4650	Dopamine Transporter Adrenergic Receptor 5-HT Receptor	Neurological Disease
Diclofensine (Ro 8-46500) is an orally active neuronal monoamine uptake inhibitor. Diclofensine blocks the uptake of dopamine, noradrenaline, and serotonin by rat brain synaptosomes with IC₅₀ values of 0.74, 2.3 and 3.7 nM, respectively. Diclofensine potentiates norepinephrine-induced hypertension and attenuates Tyramine (HY-W007606)-induced hypertension. Diclofensine produces psychostimulant and mood-elevating effects without causing sudden disappearance or withdrawal reactions. Diclofensine can be used in the research of moderate to severe depression .

HY-A0175

Butriptyline Butriptylene	5-HT Receptor	Neurological Disease
Butriptyline (Butriptylene) is an orally active tricyclic antidepressant that slightly enhances central 5-HT effects. Butriptyline does not inhibit brain norepinephrine uptake. Butriptyline can be used for depression research .

HY-14472R

Tesofensine (Standard) NS-2330 (Standard)	Dopamine Transporter Serotonin Transporter Reference Standards	Metabolic Disease
Tesofensine (Standard) is the analytical standard of Tesofensine. This product is intended for research and analytical applications. Tesofensine (NS-2330) is a triple monoamine reuptake inhibitor inducing a potent inhibition of the re-uptake process in the synaptic cleft of the neurotransmitters dopamine (DA; IC50=6.5 nM), norepinephrine (NE;IC50=1.7 nM), and serotonin (5-HT;IC50=11 nM), and with potentials as an anti-obesity agent . Tesofensine is a CNS acting anti-obesity agent .

HY-107128

Ampreloxetine hydrochloride TD-9855 hydrochloride	Serotonin Transporter	Neurological Disease
Ampreloxetine (TD-9855) hydrochloride is an orally active and CNS-penetrant inhibitor of Norepinephrine transporter (NET) and *Serotonin 5-HT uptake* transporter (SERT), but not Dopamine transporter** (DAT). Ampreloxetine hydrochloride binds norepinephrine transporters (NET) and serotonin transporters (SERT) with EC₅₀ values of 11.7 ng/mL and 50.8 ng/mL, respectively, in plasma .

HY-B0773

Paroxetine mesylate BRL29060 mesylate	Serotonin Transporter Adrenergic Receptor	Neurological Disease
Paroxetine mesylate, a phenylpiperidine derivative, is a potent and selective serotonin reuptake inhibitor (SSRI). Paroxetine mesylate is a very weak inhibitor of norepinephrine (NE) uptake but it is still more potent at this site than the other SSRIs .

HY-18610

Diclofensine hydrochloride Ro 8-4650 hydrochloride	Dopamine Transporter Adrenergic Receptor 5-HT Receptor	Neurological Disease
Diclofensine (Ro 8-46500) hydrochloride is an orally active neuronal monoamine uptake inhibitor. Diclofensine hydrochloride blocks the uptake of dopamine, noradrenaline, and serotonin by rat brain synaptosomes with IC₅₀ values of 0.74, 2.3 and 3.7 nM, respectively. Diclofensine hydrochloride potentiates norepinephrine-induced hypertension and attenuates Tyramine (HY-W007606)-induced hypertension. Diclofensine hydrochloride produces psychostimulant and mood-elevating effects without causing sudden disappearance or withdrawal reactions. Diclofensine hydrochloride can be used in the research of moderate to severe depression .

HY-P11313

Catestatin (rat) Rat chromogranin A367–387	nAChR Akt	Cardiovascular Disease
Catestatin (rat) (Rat chromogranin A367–387) is a potent, reversible, noncompetitive, and noncooperative nicotinic cholinergic antagonist derived from chromogranin A (A_367-387). Catestatin (rat) inhibits norepinephrine release in rat PC12 pheochromocytoma cells (IC₅₀ = 1.2 μM), and blocks desensitization of norepinephrine release (IC₅₀ = 0.62 μM). Catestatin (rat) exerts antiadrenergic effects through the endothelial PI3K-AKT-eNOS pathway in rat papillary muscles and isolated cardiomyocytes. Catestatin (rat) maintains mitochondrial membrane potential in I/R cardiomyocytes and increases phosphorylation of AKT at S473, GSK3β at S9, PLB at T17, and eNOS at S1179. Catestatin (rat) reverses desensitization of ²²Na ⁺ uptake. Catestatin (rat) can be used for the study of nicotinic cholinergic receptor regulation and catecholamine release control mechanisms .

HY-123398

RS-51324	Adrenergic Receptor Histamine Receptor Dopamine Receptor	Neurological Disease
RS-51324 is an oral active antidepressant agent. RS-51324 inhibitts norepinephrine uptake and reverses of Reserpine (HY-N0480)-induced hypothermia .

HY-118064A

(R)-Thionisoxetine hydrochloride LY-368975 hydrochloride	Monoamine Transporter	Neurological Disease
(R)-Thionisoxetine hydrochloride (LY-368975 hydrochloride) is a potent and selective central and peripheral norepinephrine (NE) uptake inhibitor. (R)-Thionisoxetine hydrochloride prevents 6-hydroxydopamine-induced hypothalamic NE depletion with an ED₅₀ of 0.21 mg/kg. (R)-Thionisoxetine hydrochloride can be used in the study of a variety of diseases, including depression and urinary incontinence .

HY-118064

(R)-Thionisoxetine LY-368975	Dopamine Receptor	Neurological Disease
(R)-Thionisoxetine is a potent and selective inhibitor of central and peripheral norepinephrine (NE) uptake. (R)-thionisoxetine prevented hypothalamic NE depletion by 6-hydroxydopamine with an ED₅₀ of 0.21 mg/kg. (R)-Thionisoxetine can be used for the research of a variety of diseases including depression and urinary incontinence .

HY-115762

4-Hydroxytryptamine creatinine sulfate	Endogenous Metabolite	Neurological Disease
4-Hydroxytryptamine creatinine sulfate, a tryptamine derivative, is a neurotransmitter agonist .

HY-122300C

Oxaprotiline hydrochloride (Rac)-Levoprotiline hydrochloride	Adrenergic Receptor	Neurological Disease
Oxaprotiline hydrochloride is a potent norepinephrine (NA) uptake inhibitor. Oxaprotiline hydrochloride has antidepressant activity .

HY-122300A

Oxaprotiline (Rac)-Levoprotiline	Adrenergic Receptor	Neurological Disease
Oxaprotiline ((Rac)-Levoprotiline) is a potent Norepinephrine (NE)/Noradrenaline (NA) uptake inhibitor. Oxaprotiline has antidepressant activity .

HY-129682

LY125180	5-HT Receptor Dopamine Receptor Adrenergic Receptor	Neurological Disease
LY125180 is a serotonin uptake inhibitor. LY125180 competitively inhibits the uptake of serotonin and norepinephrine by cortical synaptosomes and of dopamine by striatal synaptosomes, with K_i values of 0.06 μM, 2.2 μM and 2.5 μM respectively .

HY-14607

Besipirdine hydrochloride HP 749	Potassium Channel	Neurological Disease
Besipirdine (hydrochloride) is a potassium channel blocker with cholinergic and adrenergic activity. The cholinergic activity of Besipirdine (hydrochloride) involves stimulating phosphatidylinositol turnover and reducing potassium currents. The adrenergic activity of Besipirdine (hydrochloride) involves stimulating norepinephrine release, which is attributed to the inhibition of presynaptic α2-adrenergic receptors and the inhibition of norepinephrine uptake. Besipirdine (hydrochloride) may be used in research for Alzheimer's disease .

HY-W708023

5-APDI hydrochloride	5-HT Receptor	Neurological Disease
5-APDI hydrochloride is an indane with an amphetamine-like aminopropane group. 5-APDI hydrochloride inhibits the uptake of serotonin, dopamine, and norepinephrine by crude synaptosomes (IC50 values of 82 nM, 1,847 nM, and 849 nM, respectively) .

HY-129985

Clovoxamine DU23811	Serotonin Transporter 5-HT Receptor	Neurological Disease
Clovoxamine (DU23811) (Compound 35) has binding affinity for serotonin transporter (SERT) (K_i: 61 nM). Clovoxamine is a 5-HT and norepinephrine reuptake (NE) re-uptake inhibitor. Clovoxamine is an antidepressant .

HY-14560CR

Reboxetine mesylate (Standard) FCE20124 mesylate (Standard); PNU155950E mesylate (Standard)	Reference Standards Adrenergic Receptor	Neurological Disease
Reboxetine (mesylate) (Standard) is the analytical standard of Reboxetine (mesylate). This product is intended for research and analytical applications. Reboxetine mesylate (FCE20124 mesylate) is a potent, selective, and specific noradrenaline reuptake inhibitor (NARI) for the research of depression. Reboxetine mesylate inhibits the uptake of norepinephrine, with a K_i of 8 nM .

HY-131479A

Threo-dihydrobupropion	Drug Metabolite	Neurological Disease
Threo-dihydrobupropion is a major metabolite of Bupropion, formed via oxidation and reduction exhibit pharmacological activity. Bupropion, a dual dopamine-norepinephrine uptake inhibitor and a nicotine receptor antagonist, is widely used in the management of depression and as a smoking cessation aid .

HY-126158

SRI-29574	Dopamine Transporter Serotonin Transporter	Neurological Disease
SRI-29574 is an allosteric modulator of the dopamine transporter (DAT). SRI-29574 partially inhibits the uptake of the DAT (IC₅₀=2.3 nM) and also partially inhibits the uptake of the serotonin transporter (SERT) and norepinephrine transporter (NET). SRI-29574 may serve as a useful probe to study the function and regulatory mechanisms of DAT .

HY-122272S2

Paroxetine-d6-1 BRL29060-d₆-1	Isotope-Labeled Compounds Adrenergic Receptor Serotonin Transporter	Neurological Disease
Paroxetine-d6-1 is a deuterated labeled Paroxetine . Paroxetine, a phenylpiperidine derivative, is a potent and selective serotonin reuptake inhibitor (SSRI). Paroxetine is a very weak inhibitor of norepinephrine (NE) uptake but it is still more potent at this site than the other SSRIs .

HY-108256S

Melitracen-d6 hydrochloride	Isotope-Labeled Compounds 5-HT Receptor	Neurological Disease
Melitracen-d₆ (hydrochloride) is the deuterium labeled Melitracen hydrochloride. Melitracen hydrochloride is an orally active biphasic antidepressant and antianxiety agent. Melitracen hydrochloride can inhibit the uptake of Norepinephrine and 5-HT (serotonin) through the presynaptic membrane inducing the increase of monoamine transmitters in synaptic space .

HY-N0740R

Jatrorrhizine chloride (Standard)	Reference Standards Cholinesterase (ChE) 5-HT Receptor Bacterial	Neurological Disease Inflammation/Immunology
Jatrorrhizine (chloride) (Standard) is the analytical standard of Jatrorrhizine (chloride). This product is intended for research and analytical applications. Jatrorrhizine chloride is an alkaloid isolated from Coptis chinensis with neuroprotective, antimicrobial, antiplasmodial and antioxidant activities . Jatrorrhizine chloride is a potent and orally active inhibitor of AChE (IC50=872 nM) over >115-fold selectivity for BuChE . Jatrorrhizine chloride reduces uptake of serotonin (5-HT) and norepinephrine (NE) via inhibition of uptake-2 transporters .

HY-108256R

Melitracen hydrochloride (Standard)	5-HT Receptor Reference Standards	Neurological Disease
Melitracen (hydrochloride) (Standard) is the analytical standard of Melitracen (hydrochloride). This product is intended for research and analytical applications. Melitracen hydrochloride is an orally active biphasic antidepressant and antianxiety agent. Melitracen hydrochloride can inhibit the uptake of Norepinephrine and 5-HT (serotonin) through the presynaptic membrane inducing the increase of monoamine transmitters in synaptic space .

HY-116062

JNJ-7925476 hydrochloride	Monoamine Transporter Dopamine Transporter Adrenergic Receptor	Others
JNJ-7925476 (hydrochloride) is a triple monoamine uptake inhibitor with the ability to regulate neurotransmitter levels and antidepressant activity. JNJ-7925476 (hydrochloride) can be rapidly absorbed into the plasma in rats, with a higher concentration in the brain than in plasma. It can induce an increase in the levels of extracellular serotonin, dopamine, and norepinephrine in the rat cerebral cortex, and exhibits antidepressant activity in the mouse tail suspension test.

HY-118997

PD-89211	Dopamine Receptor	Neurological Disease
PD-89211 is a selective dopamine D4 receptor antagonist with a K_i value of 3.7 nM. PD-89211 reverses Quinpirole (HY-B1752A)-induced [3H]thymidine uptake in CHOpro5 cells (IC₅₀ = 2.1 nM). PD-89211 regulates dopamine/norepinephrine metabolism in the hippocampus and can be used for research on central nervous system disorders such as schizophrenia .

HY-18610R

Diclofensine hydrochloride (Standard) Ro 8-4650 hydrochloride (Standard)	Reference Standards Dopamine Transporter Adrenergic Receptor 5-HT Receptor	Neurological Disease
Diclofensine (Ro 8-4650) hydrochloride (Standard) is the analytical standard of Diclofensine hydrochloride. This product is intended for research and analytical applications. Diclofensine hydrochloride is an orally active neuronal monoamine uptake inhibitor. Diclofensine hydrochloride blocks the uptake of dopamine, noradrenaline, and serotonin by rat brain synaptosomes with IC₅₀ values of 0.74, 2.3 and 3.7 nM, respectively. Diclofensine hydrochloride potentiates norepinephrine-induced hypertension and attenuates Tyramine (HY-W007606)-induced hypertension. Diclofensine hydrochloride produces psychostimulant and mood-elevating effects without causing sudden disappearance or withdrawal reactions. Diclofensine hydrochloride can be used in the research of moderate to severe depression.

HY-18610S

Diclofensine-d3 hydrochloride	Isotope-Labeled Compounds Dopamine Transporter Adrenergic Receptor 5-HT Receptor	Neurological Disease
Diclofensine-d₃ (Ro-8-4650-d₃) hydrochloride is the deuterium labeled Diclofensine hydrochloride. Diclofensine hydrochloride is an orally active neuronal monoamine uptake inhibitor. Diclofensine hydrochloride blocks the uptake of dopamine, noradrenaline, and serotonin by rat brain synaptosomes with IC₅₀ values of 0.74, 2.3 and 3.7 nM, respectively. Diclofensine hydrochloride potentiates norepinephrine-induced hypertension and attenuates Tyramine (HY-W007606)-induced hypertension. Diclofensine hydrochloride produces psychostimulant and mood-elevating effects without causing sudden disappearance or withdrawal reactions. Diclofensine hydrochloride can be used in the research of moderate to severe depression.

HY-117542

D595	Histone Methyltransferase	Neurological Disease
D595 is a phenylethylamine calcium channel blocker with potent negative inotropic activity. D595 has shown significant efficacy in its corresponding pharmacological studies, especially in inhibiting the uptake of monoamine neurotransmitters. D595 has high affinity in binding to the dopamine transporter (DAT), serotonin transporter (SERT), and norepinephrine transporter (NET). Structural adjustments of D595, especially changes in the hydroxyl stereochemistry, significantly affect its interaction with the transporters, showing a specific preference for stereoisomers .

HY-B1110AR

Nomifensine maleate (Standard) (±)-Nomifensine maleate (Standard); Nomifensin maleate (Standard)	Dopamine Receptor Adrenergic Receptor Reference Standards	Neurological Disease
Nomifensine (maleate) (Standard) is the analytical standard of Nomifensine (maleate). This product is intended for research and analytical applications. Nomifensine ((±)-Nomifensine) maleate is a potent norepinephrine (NE) and dopamine (DA) reuptake inhibitor. Nomifensine maleate inhibits uptake of NE, DA and 5-HT in rat brain synaptosomes, with IC50 values of 6.6 nM, 48 nM and 830 nM, and Ki values of 4.7 nM, 26 nM and 4000 nM, respectively. Nomifensine maleate has antidepressant and analgesic effects. Nomifensine maleate is used in neurodegenerative diseases, compound addiction, and pain research .

HY-B1110R

Nomifensine (Standard) (±)-Nomifensine (Standard); Nomifensin (Standard)	Dopamine Receptor Adrenergic Receptor Reference Standards	Neurological Disease
Nomifensine (Standard) is the analytical standard of Nomifensine. This product is intended for research and analytical applications. Nomifensine ((±)-Nomifensine) is a potent norepinephrine (NE) and dopamine (DA) reuptake inhibitor. Nomifensine inhibits uptake of NE, DA and 5-HT in rat brain synaptosomes, with IC50 values of 6.6 nM, 48 nM and 830 nM, and Ki values of 4.7 nM, 26 nM and 4000 nM, respectively. Nomifensine has antidepressant and analgesic effects. Nomifensine is used in neurodegenerative diseases, compound addiction, and pain research .

HY-122300B

R-(-)-Oxaprotiline Levoprotiline	Adrenergic Receptor	Neurological Disease
R-(-)-Oxaprotiline (Levoprotiline) is an antidepressant with anticholinergic and sympathostimulatory activities. R-(-)-Oxaprotiline exhibits different abilities to block norepinephrine uptake and anticholinergic activity compared to its enantiomer C 49802 B-Ba. R-(-)-Oxaprotiline in human studies shows physiological effects consistent with those in animals. Administration of R-(-)-Oxaprotiline results in a modest increase in heart rate and arterial blood pressure. Salivation is inhibited with R-(-)-Oxaprotiline, consistent with its anticholinergic properties. R-(-)-Oxaprotiline has similar effects to the established antidepressant compound Levoprotiline and has a shorter onset of action .

HY-B1110S

Nomifensine-d3 maleate (±)-Nomifensine-d3 maleate; Nomifensin-d3 maleate	Isotope-Labeled Compounds Dopamine Receptor Adrenergic Receptor	Neurological Disease
Nomifensine-d₃ ((±)-Nomifensine-d₃) maleate is the deuterium labeled Nomifensine maleate (HY-B1110A). Nomifensine ((±)-Nomifensine) maleate is a potent norepinephrine (NE) and dopamine (DA) reuptake inhibitor. Nomifensine maleate inhibits uptake of NE, DA and 5-HT in rat brain synaptosomes, with IC₅₀ values of 6.6 nM, 48 nM and 830 nM, and K_i values of 4.7 nM, 26 nM and 4000 nM, respectively. Nomifensine maleate has antidepressant and analgesic effects. Nomifensine maleate is used in neurodegenerative diseases, compound addiction, and pain research .

HY-107128R

Ampreloxetine hydrochloride (Standard) TD-9855 hydrochloride (Standard)	Reference Standards Serotonin Transporter	Neurological Disease
Ampreloxetine hydrochloride (Standard) (TD-9855 hydrochloride (Standard)) is the analytical standard of Ampreloxetine (hydrochloride) (HY-107128). This product is intended for research and analytical applications. Ampreloxetine (TD-9855) hydrochloride is an orally active and CNS-penetrant inhibitor of Norepinephrine transporter (NET) and Serotonin 5-HT uptake transporter (SERT), but not Dopamine transporter (DAT). Ampreloxetine hydrochloride binds norepinephrine transporters (NET) and serotonin transporters (SERT) with EC₅₀ values of 11.7 ng/mL and 50.8 ng/mL, respectively, in plasma .

HY-106604

Lortalamine LM 1404	Monoamine Transporter	Neurological Disease Metabolic Disease
Lortalamine (LM 1404) is a selective norepinephrine transporter inhibitor with an IC₅₀ of <1 nM. Lortalamine is a non-tricyclic antidepressant. Lortalamine antagonises Reserpine (HY-N0480)-induced ptosis and hypothermia. Lortalamine inhibits norepinephrine uptake .

HY-A0175A

Butriptyline hydrochloride Butriptylene hydrochloride	5-HT Receptor	Neurological Disease
Butriptyline (Butriptylene) hydrochloride is an orally active tricyclic antidepressant that slightly enhances central 5-HT effects. Butriptyline hydrochloride does not inhibit brain norepinephrine uptake. Butriptyline hydrochloride can be used for depression research .

Cat. No.	Product Name	Target	Research Area

HY-P11313

Catestatin (rat) Rat chromogranin A367–387	nAChR Akt	Cardiovascular Disease
Catestatin (rat) (Rat chromogranin A367–387) is a potent, reversible, noncompetitive, and noncooperative nicotinic cholinergic antagonist derived from chromogranin A (A_367-387). Catestatin (rat) inhibits norepinephrine release in rat PC12 pheochromocytoma cells (IC₅₀ = 1.2 μM), and blocks desensitization of norepinephrine release (IC₅₀ = 0.62 μM). Catestatin (rat) exerts antiadrenergic effects through the endothelial PI3K-AKT-eNOS pathway in rat papillary muscles and isolated cardiomyocytes. Catestatin (rat) maintains mitochondrial membrane potential in I/R cardiomyocytes and increases phosphorylation of AKT at S473, GSK3β at S9, PLB at T17, and eNOS at S1179. Catestatin (rat) reverses desensitization of ²²Na ⁺ uptake. Catestatin (rat) can be used for the study of nicotinic cholinergic receptor regulation and catecholamine release control mechanisms .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0740

Jatrorrhizine chloride 3 Publications Verification	Alkaloids Monophenols Coptis chinensis Franch. Ranunculaceae Phenols Plants Isoquinoline Alkaloids Source Classification	Cholinesterase (ChE) 5-HT Receptor Bacterial
Jatrorrhizine chloride is an alkaloid isolated from?Coptis chinensis with neuroprotective, antimicrobial, antiplasmodial and antioxidant activities . Jatrorrhizine chloride is a potent and orally active inhibitor of?AChE?(IC₅₀=872 nM) over >115-fold selectivity for BuChE . Jatrorrhizine chloride reduces uptake of serotonin (5-HT) and norepinephrine (NE) via inhibition of uptake-2 transporters .

HY-N0749

Jatrorrhizine	Alkaloids Monophenols other families Phenols Plants Isoquinoline Alkaloids Source Classification	Cholinesterase (ChE) 5-HT Receptor Bacterial
Jatrorrhizine is an alkaloid isolated from Coptis chinensis with neuroprotective, antimicrobial, antiplasmodial and antioxidant activities . Jatrorrhizine is a potent and orally active inhibitor of AChE (IC₅₀=872 nM) over >115-fold selectivity for BuChE . Jatrorrhizine reduces uptake of serotonin (5-HT) and norepinephrine (NE) via inhibition of uptake-2 transporters .

HY-N0749A

Jatrorrhizine hydroxide 3 Publications Verification	Alkaloids Monophenols Coptis chinensis Franch. Ranunculaceae Phenols Plants Isoquinoline Alkaloids Source Classification	Cholinesterase (ChE) 5-HT Receptor Bacterial
Jatrorrhizine hydroxide is an alkaloid isolated from Coptis chinensis with neuroprotective, antimicrobial, antiplasmodial and antioxidant activities . Jatrorrhizine hydroxide is a potent and orally active inhibitor of AChE (IC₅₀=872 nM) over >115-fold selectivity for BuChE . Jatrorrhizine hydroxide reduces uptake of serotonin (5-HT) and norepinephrine (NE) via inhibition of uptake-2 transporters .

HY-115762

4-Hydroxytryptamine creatinine sulfate	Alkaloids Neurological Disease Classification of Application Fields Endogenous metabolite Disease Research Fields Indole Alkaloids Source Classification	Endogenous Metabolite
4-Hydroxytryptamine creatinine sulfate, a tryptamine derivative, is a neurotransmitter agonist .

HY-N0740R

Jatrorrhizine chloride (Standard)	Alkaloids Monophenols Coptis chinensis Franch. Ranunculaceae Phenols Plants Isoquinoline Alkaloids Source Classification	Reference Standards Cholinesterase (ChE) 5-HT Receptor Bacterial
Jatrorrhizine (chloride) (Standard) is the analytical standard of Jatrorrhizine (chloride). This product is intended for research and analytical applications. Jatrorrhizine chloride is an alkaloid isolated from Coptis chinensis with neuroprotective, antimicrobial, antiplasmodial and antioxidant activities . Jatrorrhizine chloride is a potent and orally active inhibitor of AChE (IC50=872 nM) over >115-fold selectivity for BuChE . Jatrorrhizine chloride reduces uptake of serotonin (5-HT) and norepinephrine (NE) via inhibition of uptake-2 transporters .

Cat. No.	Product Name	Chemical Structure

HY-122272S2

Paroxetine-d6-1
Paroxetine-d6-1 is a deuterated labeled Paroxetine . Paroxetine, a phenylpiperidine derivative, is a potent and selective serotonin reuptake inhibitor (SSRI). Paroxetine is a very weak inhibitor of norepinephrine (NE) uptake but it is still more potent at this site than the other SSRIs .

HY-108256S

Melitracen-d6 hydrochloride
Melitracen-d₆ (hydrochloride) is the deuterium labeled Melitracen hydrochloride. Melitracen hydrochloride is an orally active biphasic antidepressant and antianxiety agent. Melitracen hydrochloride can inhibit the uptake of Norepinephrine and 5-HT (serotonin) through the presynaptic membrane inducing the increase of monoamine transmitters in synaptic space .

HY-18610S

Diclofensine-d3 hydrochloride

Diclofensine-d₃ (Ro-8-4650-d₃) hydrochloride is the deuterium labeled Diclofensine hydrochloride. Diclofensine hydrochloride is an orally active neuronal monoamine uptake inhibitor. Diclofensine hydrochloride blocks the uptake of dopamine, noradrenaline, and serotonin by rat brain synaptosomes with IC₅₀ values of 0.74, 2.3 and 3.7 nM, respectively. Diclofensine hydrochloride potentiates norepinephrine-induced hypertension and attenuates Tyramine (HY-W007606)-induced hypertension. Diclofensine hydrochloride produces psychostimulant and mood-elevating effects without causing sudden disappearance or withdrawal reactions. Diclofensine hydrochloride can be used in the research of moderate to severe depression.

HY-B1110S

Nomifensine-d3 maleate

Nomifensine-d₃ ((±)-Nomifensine-d₃) maleate is the deuterium labeled Nomifensine maleate (HY-B1110A). Nomifensine ((±)-Nomifensine) maleate is a potent norepinephrine (NE) and dopamine (DA) reuptake inhibitor. Nomifensine maleate inhibits uptake of NE, DA and 5-HT in rat brain synaptosomes, with IC₅₀ values of 6.6 nM, 48 nM and 830 nM, and K_i values of 4.7 nM, 26 nM and 4000 nM, respectively. Nomifensine maleate has antidepressant and analgesic effects. Nomifensine maleate is used in neurodegenerative diseases, compound addiction, and pain research .

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norepinephrine uptake

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