372-66-7
372-66-7
Chemical Structure
Heptaminol
- CAS. Nr.: 372-66-7
- Formula:C8H19NO
- Molecular Weight:145.25
IUPAC Name: 6-amino-2-methylheptan-2-ol
InChIKey: LREQLEBVOXIEOM-UHFFFAOYSA-N
SMILES: OC(C)(CCCC(C)N)C
Biological Activity: Heptaminol is a fatty amine with pressor properties and a potential antihypotension agent. Heptaminol is also a competitive inhibitor of norepinephrine uptake and an inhibitor of nicotine-induced catecholamine release (IC50: 650 μM). Heptaminol does not inhibit norepinephrine release induced by 59 mM K+ but rather inhibits high-affinity Na+-dependent norepinephrine uptake[1][2].
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Heptaminol | ≥98.0% | Heptaminol is a fatty amine with pressor properties and a potential antihypotension agent. Heptaminol is also a competitive inhibitor of norepinephrine uptake and an inhibitor of nicotine-induced catecholamine release (IC50: 650 μM). Heptaminol does not inhibit norepinephrine release induced by 59 mM K+ but rather inhibits high-affinity Na+-dependent norepinephrine uptake. | ||||||||||||||||||||
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References
- [1]. Dib J, et al. Is heptaminol a (major) metabolite of octodrine? Drug Test Anal. 2019 Nov;11(11-12):1761-1763. [Content Brief]
- [2]. Delicado EG, et al. Effect of tuamine, heptaminol and two analogues on uptake and release of catecholamines in cultured chromaffin cells. Biochem Pharmacol. 1990 Aug 15;40(4):821-5. [Content Brief]
Keywords
