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p65-p50 heterodimer

" in MedChemExpress (MCE) Product Catalog:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-184324
    Anti-inflammatory agent 116

    		NF-κB p38 MAPK Reactive Oxygen Species (ROS) Interleukin Related TNF Receptor COX IKK ERK JNK Metabolic Disease
    Anti-inflammatory agent 116 is an anti-inflammatory agent. Anti-inflammatory agent 116 binds to the p50 subunit and impairs the DNA-binding ability of the p65-p50 heterodimer. Anti-inflammatory agent 116 inhibits the abnormal activation of the NF-κB/MAPK signaling pathway. Anti-inflammatory agent 116 inhibits LPS-induced NO and MtROS production, IL-1β and TNF-α secretion, iNOS and COX-2 expression, phosphorylation of IKK, IκB, p65, p38, ERK and JNK, as well as nuclear translocation of p65. Anti-inflammatory agent 116 alleviates sepsis-associated acute liver injury in mice. Anti-inflammatory agent 116 can be used for the research of sepsis-associated acute liver injury .
    Anti-inflammatory agent 116

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