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Results for "

phenolic derivative

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Drug Derivative (6) Apoptosis (5) Bacterial (6) Biochemical Assay Reagents (5) Carboxypeptidase (1) COX (1) Drug Intermediate (5) Endogenous Metabolite (5) Environmental Pollutants (1) Fluorescent Dye (1) Fungal (2) GABA Receptor (1) GSK-3 (2) HBV (1) Insecticide (1) Interleukin Related (3) Isotope-Labeled Compounds (1) Keap1-Nrf2 (1) Neprilysin (1) NF-κB (1) NO Synthase (1) Parasite (2) PDI (1) Reference Standards (5) Sirtuin (1) Src (1) Tyrosinase (2)
By Research Areas:	Cancer (9) Cardiovascular Disease (2) Infection (15) Inflammation/Immunology (6) Metabolic Disease (3) Neurological Disease (3)

By Targets:

Drug Derivative (6)

Apoptosis (5)

Bacterial (6)

Biochemical Assay Reagents (5)

Carboxypeptidase (1)

COX (1)

Drug Intermediate (5)

Endogenous Metabolite (5)

Environmental Pollutants (1)

Fluorescent Dye (1)

Fungal (2)

GABA Receptor (1)

GSK-3 (2)

HBV (1)

Insecticide (1)

Interleukin Related (3)

Isotope-Labeled Compounds (1)

Keap1-Nrf2 (1)

Neprilysin (1)

NF-κB (1)

NO Synthase (1)

Parasite (2)

PDI (1)

Reference Standards (5)

Sirtuin (1)

Src (1)

Tyrosinase (2)

By Research Areas:

Cancer (9)

Cardiovascular Disease (2)

Infection (15)

Inflammation/Immunology (6)

Metabolic Disease (3)

Neurological Disease (3)

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: Drug Derivative

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-Y0264

4-Hydroxybenzoic acid	Endogenous Metabolite Bacterial	Infection
4-Hydroxybenzoic acid, a phenolic derivative of benzoic acid, could inhibit most gram-positive and some gram-negative bacteria, with an IC₅₀ of 160 μg/mL.

HY-W105135

2,6-Dichloroquinone-4-chloroimide	Biochemical Assay Reagents	Others
2,6-Dichloroquinone-4-chloroimide is a spray reagent for organic compounds. 2,6-Dichloroquinone-4-chloroimide can be used in thin-layer chromatograms and detecting phenol and its derivatives. 2,6-Dichloroquinone-4-chloroimide can be used as an optical sensor for rapid detection of permethrin in treated wood .

HY-116152

Cipepofol Ciprofol; HSK3486	GABA Receptor Sirtuin Keap1-Nrf2 Apoptosis	Cardiovascular Disease Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Cipepofol (Ciprofol), a novel 2,6-disubstituted phenol derivative, is a positive allosteric modulator and direct agonist of the GABA_A receptor. Cipepofol can cause the central nerve inhibition and promote sleep based on the structural modification of Propofol (HY-B0649). Cipepofol can activate the sirtuin1 (Sirt1)/Nrf2 pathway. Cipepofol protects the heart against Isoproterenol (ISO; HY-B0468)-induced myocardial infarction by reducing cardiac oxidative stress, inflammatory response and cardiomyocyte apoptosis .

HY-107369

4-Butylresorcinol Butylresorcinol	Tyrosinase	Others
4-Butylresorcinol is a phenol derivative which can inhibit tyrosinase with IC₅₀ of 11.27 μM.

HY-N6599

3-Feruloylquinic acid 3-O-Feruloylquinic acid	Interleukin Related COX NO Synthase NF-κB	Inflammation/Immunology
3-Feruloylquinic acid (3-O-Feruloylquinic acid), a derivative of quinic acid-bound phenolic acid, shows antioxidant and anti-inflammatory activities .

HY-N4168

3-O-Caffeoylquinic acid methyl ester	HBV	Infection Cancer
3-O-Caffeoylquinic acid methyl ester is a monocaffeoylquinic acid derivative and phenolic acid component, which can be found in the whole plant of Pyrrosia calvata (Backer) Ching and the flower buds of Lonicera japonica Thunb .

HY-Y0264S1

4-Hydroxybenzoic acid-d4	Endogenous Metabolite Bacterial	Infection
4-Hydroxybenzoic acid-d₄ is the deuterium labeled 4-Hydroxybenzoic acid. 4-Hydroxybenzoic acid, a phenolic derivative of benzoic acid, could inhibit most gram-positive and some gram-negative bacteria, with an IC50 of 160 μg/mL.

HY-70003

Carboxypeptidase G2 (CPG2) Inhibitor CPG2 Inhibitor	Carboxypeptidase	Cancer
Carboxypeptidase G2 (CPG2) Inhibitor is a novel CPG2 inhibitor with an K_i of 0.3 μM. Carboxypeptidase G2 (CPG2) Inhibitor effectively neutralizes the CPG2 activity in non-tumor sites, allowing for earlier administration of the drug and forming a complementary strategy with antibody clearance strategies. Carboxypeptidase G2 (CPG2) Inhibitor can be used for the study of antibody-directed enzyme prodrug therapy (ADEPT) .

HY-W012815

3-Methylcatechol	Biochemical Assay Reagents Drug Intermediate	Others
3-Methylcatechol is a phenolic derivative that can be produced by Pseudomonas putida MC2. 3-Methylcatechol can serve as a molecular building block in chemical synthesis to produce other active compounds .

HY-Y0264R

4-Hydroxybenzoic acid (Standard)	Reference Standards Endogenous Metabolite Bacterial	Infection
4-Hydroxybenzoic acid (Standard) is the analytical standard of 4-Hydroxybenzoic acid. This product is intended for research and analytical applications. 4-Hydroxybenzoic acid, a phenolic derivative of benzoic acid, could inhibit most gram-positive and some gram-negative bacteria, with an IC50 of 160 μg/mL.

HY-30014

4-Bromo-7-azaindole 1 Publications Verification	Drug Intermediate	Others
4-Bromo-7-azaindole is a brominated derivative of 7-azaindole. 4-Bromo-7-azaindole serves as a substrate for palladium-catalyzed C-N and C-O cross-coupling reactions, reacting with amides, amines, amino acid esters and phenols .

HY-Y0264S

4-Hydroxybenzoic acid-13C6	Isotope-Labeled Compounds	Infection
4-Hydroxybenzoic acid- ¹³C6 is the ¹³C labeled isotope of 4-Hydroxybenzoic acid- ¹³C6.4-Hydroxybenzoic acid is a phenolic derivative of benzoic acid, which can inhibit most Gram-positive bacteria and some Gram-negative bacteria with an IC50 value of 160 μg/mL.

HY-Y0264S2

4-Hydroxybenzoic acid-13c	Bacterial Endogenous Metabolite	Infection
4-Hydroxybenzoic acid- ¹³C is the ¹³C labeled 4-Hydroxybenzoic acid . 4-Hydroxybenzoic acid, a phenolic derivative of benzoic acid, could inhibit most gram-positive and some gram-negative bacteria, with an IC₅₀ of 160 μg/mL .

HY-N2492

(E)-Methyl 4-coumarate Methyl trans-p-coumarate	Apoptosis Interleukin Related GSK-3 Parasite	Infection Cancer
(E)-Methyl 4-coumarate (Methyl 4-hydroxycinnamate) is a phenolic compound and derivative of Cinnamic acid (HY-N0610A). (E)-Methyl 4-coumarate can be found in several plants, such as the leaves of Allium cepa and Morinda citrifolia L. (E)-Methyl 4-coumarate, when combined with Carnosic acid (HY-N0644), induces Apoptosis. (E)-Methyl 4-coumarate inhibits GSK3β activity and modulates inflammatory cytokine levels (increasing IL-10 and decreasing IL-4). (E)-Methyl 4-coumarate combined with Carnosic acid exhibits anticancer effects against acute myeloid leukemia. (E)-Methyl 4-coumarate ameliorates Plasmodium berghei NK65 infection .

HY-150175

HKSOX-1	Fluorescent Dye	Inflammation/Immunology
HKSOX-1 and its derivatives (HKSOX-1r and HKSOX-1m) are novel fluorescent probes designed for highly sensitive and selective detection of the superoxide anion radical (O₂ ^•−) in cellular environments. These probes utilize an aryl trifluoromethanesulfonate group that undergoes O₂ ^•−-mediated cleavage, releasing a free phenol and emitting fluorescence. They demonstrate excellent specificity and sensitivity across various pH ranges, withstand interference from strong oxidants and reductants typical in cellular contexts. HKSOX-1r, optimized for cellular retention, has been effectively employed in diverse assays including confocal imaging, flow cytometry, and zebrafish embryo studies, highlighting its utility in investigating O₂ ^•− roles in inflammation, mitochondrial stress, and other physiological processes .

HY-W039169

4-Chloroguaiacol 4-Chloro-2-methoxyphenol	Bacterial	Infection
4-Chloroguaiaco (4-Chloro-2-methoxyphenol) is a phenol derivative, with antimicrobial activity. 4-Chloroguaiaco shows inhibition against S. aureus and E. coli with MICs of both 110 μg/mL .

HY-N10936

Denudaquinol	Others	Others
Denudaquinol is a phenolic derivative. Denudaquinol can be isolated from M. denudata. Denudaquinol has cytotoxicity against the SFME and r/mHMSFME-1 cell lines .

HY-14570

Triphen diol	Apoptosis	Cancer
Triphen diol is a phenol diol derivative, which has excellent anticancer activity against pancreatic cancer and cholangiocarcinoma, and can induce pancreatic cell apoptosis through two mechanisms, caspase-mediated and caspase-independent .

HY-N12216

Cyanidin 3-sophoroside-5-glucoside	Others	Others
Cyanidin 3-sophoroside-5-glucoside is the main anthocyanin in purple-fleshed sweet potato and affects the antioxidant activity of purple-fleshed sweet potato .

HY-W010235

3,5-Dimethoxytoluene	Drug Derivative	Infection
3,5-Dimethoxytoluene, a methylated phenolic derivative, is one of characteristic scent compounds emitted from flowers of most rose varieties. 3,5-Dimethoxytoluene shows significant fumigant toxicity against L. serricorne and L. bostrychophila with LC₅₀ values of 4.99 mg/L air and 0.91 mg/L air, respectively .

HY-W205745

Bengamin hydrochloride 4-(Aminomethyl)phenol hydrochloride	Drug Intermediate	Infection
Bengamin (4-(Aminomethyl)phenol) hydrochloride is a drug intermediate that can be used for the synthesis of benzylguanidine derivatives, and it possesses antibacterial activity .

HY-121959

4-Acetylphenoxyacetic acid	Biochemical Assay Reagents	Metabolic Disease
4-Acetylphenoxyacetic acid is a phenoxyacetic acid derivative. 4-Acetylphenoxyacetic acid can be synthesized from para-acetyl phenol. 4-Acetylphenoxyacetic acid can be used to study phenylacetic acid transport system of Pseudomonas putida U through the aerobic catabolism of phenylacetic aced derivative .

HY-139797

SCH 47896	Drug Derivative Neprilysin	Cardiovascular Disease
SCH 47896 is a phenolic derivative of SCH39370 (HY-139803), a potent specific inhibitor of metalloendopeptidase (NEP). SCH 47896 can be used for the research of cardiovascular disease, such as hypertension .

HY-W010235R

3,5-Dimethoxytoluene (Standard)	Reference Standards Biochemical Assay Reagents	Infection
3,5-Dimethoxytoluene (Standard) is the analytical standard of 3,5-Dimethoxytoluene. This product is intended for research and analytical applications. 3,5-Dimethoxytoluene, a methylated phenolic derivative, is one of characteristic scent compounds emitted from flowers of most rose varieties. 3,5-Dimethoxytoluene shows significant fumigant toxicity against L. serricorne and L. bostrychophila with LC50 values of 4.99 mg/L air and 0.91 mg/L air, respectively[1].

HY-116631

Sarisan Asaricin	Fungal Insecticide	Infection
Sarisan (Asaricin) is a phenolic derivative with antifungal and insecticidal activity. Sarisan can be found in the stem bark of Ocotea opifera Mart. .

HY-W754777

IPPD-Q	Endogenous Metabolite Environmental Pollutants	Others
IPPD-Q is an antioxidant phenolic quinone derivative of p-phenylenediamine . IPPD-Q is one of the most acutely toxic emerging contaminants in urban waters.

HY-N8618

Erythro-guaiacylglycerol-β-O-4'-dihydroconiferyl alcohol	Others	Others
Erythro-guaiacylglycerol-β-O-4'-dihydroconiferyl alcohol was identified as one of the phenolic compounds isolated from Canadian maple syrup (MS-BuOH). It exhibited antioxidant properties along with other phenolic compounds and coumarins isolated from the syrup. These compounds showed varying degrees of antioxidant activity, with phenolic derivatives and coumarins showing superior activity, more so than lignans and flavonoids. This study marks the first time that 16 of the 23 phenolic compounds, including Erythro-guaiacylglycerol-β-O-4'-dihydroconiferyl alcohol, have been identified in maple syrup .

HY-107369R

4-Butylresorcinol (Standard) Butylresorcinol (Standard)	Reference Standards Tyrosinase	Others
4-Butylresorcinol (Standard) is the analytical standard of 4-Butylresorcinol. This product is intended for research and analytical applications. 4-Butylresorcinol is a phenol derivative which can inhibit tyrosinase with IC₅₀ of 11.27 μM.

HY-W012815R

3-Methylcatechol (Standard)	Biochemical Assay Reagents Reference Standards Drug Intermediate	Others
3-Methylcatechol (Standard) is the analytical standard of 3-Methylcatechol (HY-W012815). This product is intended for research and analytical applications. 3-Methylcatechol is a phenolic derivative that can be produced by Pseudomonas putida MC2. 3-Methylcatechol can serve as a molecular building block in chemical synthesis to produce other active compounds .

HY-170971

Src Inhibitor 4	Apoptosis Src	Cancer
Src Inhibitor 4 (Compound 18) is a derivative of KX-01 and an Src inhibitor. Src Inhibitor 4 can inhibit tumor cells, disrupt microtubules, and induce cell cycle arrest, apoptosis, and immunogenic cell death. After the introduction of phenolic or aniline functionality, Src Inhibitor 4 can serve as a payload attachment site for antibody-drug conjugates and has anti-tumor activity .

HY-N2492R

(E)-Methyl 4-coumarate (Standard) Methyl trans-p-coumarate (Standard)	Reference Standards Apoptosis Parasite Interleukin Related GSK-3	Infection Cancer
(E)-Methyl 4-coumarate (Standard) is the analytical standard of (E)-Methyl 4-coumarate (HY-N2492). This product is intended for research and analytical applications. (E)-Methyl 4-coumarate (Methyl 4-hydroxycinnamate) is a phenolic compound and derivative of Cinnamic acid (HY-N0610A). (E)-Methyl 4-coumarate can be found in several plants, such as the leaves of Allium cepa and Morinda citrifolia L. (E)-Methyl 4-coumarate, when combined with Carnosic acid (HY-N0644), induces Apoptosis. (E)-Methyl 4-coumarate inhibits GSK3β activity and modulates inflammatory cytokine levels (increasing IL-10 and decreasing IL-4). (E)-Methyl 4-coumarate combined with Carnosic acid exhibits anticancer effects against acute myeloid leukemia. (E)-Methyl 4-coumarate ameliorates Plasmodium berghei NK65 infection .

HY-N12838

Glycerol-2-(3-methoxy-4-hydroxybenzoicacid)ether	Others	Others
Glycerol-2-(3-methoxy-4-hydroxybenzoicacid)ether is a phenolic derivative and can be isolated from Picrasma quassioides (D. Don) Benn .

HY-N17531

4-(β-D-Glucopyranosyloxy)benzenepropanoic acid	Drug Derivative	Others
4-(β-D-Glucopyranosyloxy) benzenepropanoic acid is a phenolic acid glycoside natural product, which has an O-β-D-glucoside structure formed by a phenylpropanoic acid derivative and glucose .

HY-N18765

Dragons blood extract	Bacterial	Infection Inflammation/Immunology
Dragons blood extract contains a variety of bioactive compounds, including alkaloids, flavonoids, phenolic acids, and chalcone derivatives, which have antibacterial, anti-inflammatory, antioxidant, and wound-healing effects.

HY-19410

ORG-25435	Drug Derivative	Neurological Disease
ORG-25435 is an alpha amino acid phenolic ester derivative. ORG-25435 has intravenous anesthesia activity. ORG-25435 can be used for anesthesia related research .

HY-W015811

3-N-Propylphenol	PDI	Metabolic Disease Inflammation/Immunology Cancer
3-N-Propylphenol is a small phenolic derivative containing a hydroxyl aryl group that competitively inhibits the binding of the peptide to pancreatic-specific protein disulfide isomerase (PDIp). 3-Propylphenol can be used for research on pancreatic-related diseases .

HY-N19785

11,12-Dimethyl chebulate	Fungal	Infection
11,12-Dimethyl chebulate is a phenolic acid chebulate derivative that can be found in Acer saccharum fall leaves and Terminalia dhofarica leaf extracts. 11,12-Dimethyl exhibits antifungal activity and DPPH scavenging activity.11,12-Dimethyl chebulate can be used for the research of fungal infection .

HY-N17138

threo-1-(4-Hydroxyphenyl)-1-methoxy-2,3-propanediol	Others	Inflammation/Immunology Cancer
threo-1-(4-Hydroxyphenyl)-1-methoxy-2,3-propanediol is an aromatic propanediol phenolic derivative containing methoxy and hydroxyl groups. It can be naturally extracted from the dried aerial parts of Abies delavayi Franch. var. delavayi (Cangshan fir) from Dali, Yunnan, China. This source plant produces anti-inflammatory and anti-tumor active components .

HY-186094

(S,S)-Demethyl-reboxetine	Drug Derivative Drug Intermediate	Neurological Disease
(S,S)-Demethyl-reboxetine is a key phenolic precursor for the preparation of the PET tracer (S,S)-[ ¹¹C]-MeNER. (S,S)-Demethyl-reboxetine is also the demethylated derivative of Reboxetine (HY-14560). Efficient synthesis of the norepinephrine transporter (NET)-targeted tracer is achieved through ¹¹C methylation of (S,S)-Demethyl-reboxetine. (S,S)-Demethyl-reboxetine serves as a core raw material for the synthesis of radiopharmaceuticals related to NET imaging .

HY-N17337

Etrogol	Drug Derivative	Others
Etrogol is a prenylphenol derivative. Etrogol exists in the roots and root barks of citron (C. medica L. var. ethrog ENGL.) .

Cat. No.	Product Name

HY-L021M

Natural Product and Natural Product-Like Compound Library	5,019 compounds
From the discovery of traditional Chinese medicine to modern antibiotics, natural products have played an important role in the drug development process. A review of all FDA-approved drugs shows that natural products and natural product-like compounds account for more than one-third of all approved drugs. Nearly half of that came from mammals, a quarter from microbes, and a quarter from plants. Over time, the proportion of microbial natural products and natural product derivatives in approved drugs has increased. Natural products have natural advantages in drug development and can be used as lead compounds in drug discovery for drug identification and mechanism research. MCE provides a unique collection of 5,019 natural compounds and natural product-like compounds that contain saccharides and glycosides, phenylpropanoids, quinones, flavonoids, terpenoids and glycosides, steroids, alkaloid, phenols, acids and aldehydes. Natural product and natural product-like compounds library is a useful tool for drug discovery that can be used for high-throughput screening (HTS) and high-content screening (HCS).

Natural Product and Natural Product-Like Compound Library

5,019 compounds

From the discovery of traditional Chinese medicine to modern antibiotics, natural products have played an important role in the drug development process. A review of all FDA-approved drugs shows that natural products and natural product-like compounds account for more than one-third of all approved drugs. Nearly half of that came from mammals, a quarter from microbes, and a quarter from plants. Over time, the proportion of microbial natural products and natural product derivatives in approved drugs has increased. Natural products have natural advantages in drug development and can be used as lead compounds in drug discovery for drug identification and mechanism research.

MCE provides a unique collection of 5,019 natural compounds and natural product-like compounds that contain saccharides and glycosides, phenylpropanoids, quinones, flavonoids, terpenoids and glycosides, steroids, alkaloid, phenols, acids and aldehydes. Natural product and natural product-like compounds library is a useful tool for drug discovery that can be used for high-throughput screening (HTS) and high-content screening (HCS).

Cat. No.	Product Name	Type