1786411-17-3
Chemical Structure
HKSOX-1
- CAS No.: 1786411-17-3
- Formula:C23H6F10O11S2
- Molecular Weight:712.40
IUPAC Name: 2',4',5',7'-tetrafluoro-3-oxo-3',6'-bis(((trifluoromethyl)sulfonyl)oxy)-3H-spiro[isobenzofuran-1,9'-xanthene]-5-carboxylic acid
InChIKey: XSHHIFZGVZWRBI-UHFFFAOYSA-N
SMILES: O=C(C1=CC=C2C(C(OC23C4=CC(F)=C(C(F)=C4OC5=C(C(OS(=O)(C(F)(F)F)=O)=C(C=C53)F)F)OS(=O)(C(F)(F)F)=O)=O)=C1)O
Biological Activity: HKSOX-1 and its derivatives (HKSOX-1r and HKSOX-1m) are novel fluorescent probes designed for highly sensitive and selective detection of the superoxide anion radical (O2•−) in cellular environments. These probes utilize an aryl trifluoromethanesulfonate group that undergoes O2•−-mediated cleavage, releasing a free phenol and emitting fluorescence. They demonstrate excellent specificity and sensitivity across various pH ranges, withstand interference from strong oxidants and reductants typical in cellular contexts. HKSOX-1r, optimized for cellular retention, has been effectively employed in diverse assays including confocal imaging, flow cytometry, and zebrafish embryo studies, highlighting its utility in investigating O2•− roles in inflammation, mitochondrial stress, and other physiological processes[1].
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HKSOX-1 | HKSOX-1 and its derivatives (HKSOX-1r and HKSOX-1m) are novel fluorescent probes designed for highly sensitive and selective detection of the superoxide anion radical (O2•−) in cellular environments. These probes utilize an aryl trifluoromethanesulfonate group that undergoes O2•−-mediated cleavage, releasing a free phenol and emitting fluorescence. They demonstrate excellent specificity and sensitivity across various pH ranges, withstand interference from strong oxidants and reductants typical in cellular contexts. HKSOX-1r, optimized for cellular retention, has been effectively employed in diverse assays including confocal imaging, flow cytometry, and zebrafish embryo studies, highlighting its utility in investigating O2•− roles in inflammation, mitochondrial stress, and other physiological processes. | |||||||||||||||||||||
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Keywords
