1. Metabolic Enzyme/Protease
    Anti-infection
  2. Endogenous Metabolite
    Bacterial

4-Hydroxybenzoic acid 

Cat. No.: HY-Y0264 Purity: >97.0%
Handling Instructions

4-Hydroxybenzoic acid, a phenolic derivative of benzoic acid, could inhibit most gram-positive and some gram-negative bacteria, with an IC50 of 160 μg/mL.

For research use only. We do not sell to patients.

4-Hydroxybenzoic acid Chemical Structure

4-Hydroxybenzoic acid Chemical Structure

CAS No. : 99-96-7

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
1 g USD 50 In-stock
Estimated Time of Arrival: December 31
5 g   Get quote  
10 g   Get quote  

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  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

4-Hydroxybenzoic acid, a phenolic derivative of benzoic acid, could inhibit most gram-positive and some gram-negative bacteria, with an IC50 of 160 μg/mL.

IC50 & Target[1]

Bacteria

160 μg/mL (IC50)

Human Endogenous Metabolite

 

In Vitro

Most of the gram-positive and some gram-negative bacteria are sensitive to trans 4-Hydroxycinnamic acid (4-HBA) and 4-Hydroxybenzoic acid at IC50 concentrations of 100-170 and 160 μg/mL, respectively. The antimicrobial activities of 4-Hydroxycinnamic acid and t4-HCA against 11 food pathogenic bacteria, 6 plant pathogenic bacteria, 2 yeasts and 15 plant pathogenic fungi are tested by the paper disc method. These compounds inhibit the growth of most of the bacteria and yeasts at concentrations of 200-400 μg. However, the inhibition is more effective against most of the gram-positive bacteria. When tested by the paper disc method, 4-Hydroxycinnamic acid has stronger antimicrobial activity than t4-HCA against S. aureus, L. mesenteroides, S. cerevisiae and C. albicans at a concentration of 50 μg. However, no inhibitory effect against fungi was observed at concentrations even up to 1000 μg[1].

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 7.2401 mL 36.2004 mL 72.4008 mL
5 mM 1.4480 mL 7.2401 mL 14.4802 mL
10 mM 0.7240 mL 3.6200 mL 7.2401 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

138.12

Formula

C₇H₆O₃

CAS No.

99-96-7

SMILES

O=C(O)C1=CC=C(O)C=C1

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
4-Hydroxybenzoic acid
Cat. No.:
HY-Y0264
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4-Hydroxybenzoic acid

Cat. No.: HY-Y0264