296 Results for "

primary amine groups

" in MedChemExpress (MCE) Product Catalog:
Products (296)

296 Results for "primary amine groups" in MCE Product Catalog:

8
8 Publications Verification
Cat. No.: HY-Y0623
CAS No.: 6066-82-6
Synonyms: HOSu; 1-Hydroxy-2,5-pyrrolidinedione
N-Hydroxysuccinimide (HOSu; 1-Hydroxy-2,5-pyrrolidinedione) is a covalent crosslinker commonly used in bioconjugation technology with a primary amine group. N-Hydroxysuccinimide reacts with amino groups (-NH2) to form a stable amide bond, which can modify amino-containing biomolecules. N-Hydroxysuccinimide can be used, for example, for protein labeling with fluorescent dyes and enzymes, surface activation of chromatography supports, microbeads, nanoparticles and microarray slides, and chemical synthesis of peptides. N-Hydroxysuccinimide has a wide range of applications in biomaterial synthesis (such as collagen, chitosan crosslinking), drug delivery systems (such as hydrogel preparation) and tissue engineering .
loading...
    loading...
5
5 Cited Publications
Cat. No.: HY-D0975
CAS No.: 92921-24-9
Sulfo-SMCC sodium is a commonly used hetero-bifunctional, noncleavable ADC crosslinker bearing N-hydroxysuccinimide (NHS) ester and maleimide groups to react with primary amines and sulfhydryl groups, respectively.
loading...
    loading...
3
3 Cited Publications
Cat. No.: HY-111377
CAS No.: 359860-27-8
Purity:  99.79%
Amine-PEG3-Biotin is a signal amplification label containing a biotin group and a terminal primary amine group .
loading...
    loading...
1
1 Cited Publications
Cat. No.: HY-W591461
Target:  

Liposome

Research Areas:  

Cancer

DSPE-PEG-COOH, MW 2000 is a phospholipid polyPEG which can be used to prepare liposomes or nanoparticles. The terminal carboxylic acid can react with primary amine groups to form a stable amide bond.
loading...
    loading...
1
1 Cited Publications
Cat. No.: HY-D0715
CAS No.: 38183-12-9
Synonyms: Ro 20-7234
Fluorescamine is a spirocyclic compound that is non-fluorescent. Fluorescamine reacts rapidly with primary amine groups in proteins under alkaline conditions to generate products with strong fluorescence (Ex/Em: 390/475 nm). Fluorescamine can be used to detect amine-containing compounds, including amino acids, peptides, and proteins .
loading...
    loading...
1
1 Cited Publications
Cat. No.: HY-NP001
Synonyms: Cationic Bovine Serum Albumin
Cationic BSA Protein (Cationic Bovine Serum Albumin) is a bovine serum albumin (BSA) modified with excess ethylenediamine, which has enhanced immunogenicity compared to native BSA. Positively charged primary amines block all negatively charged carboxyl groups, making Cationic BSA Protein a cationic protein. Cationic BSA Protein has remarkable neuroprotective effects on ischemic stroke when in combination with Tanshinone IIA (HY-N0135) .
loading...
    loading...
1
1 Cited Publications
Cat. No.: HY-W591424
CAS No.: 92451-01-9
Synonyms: mPEG2000-SC; mPEG2000-Succinimidyl ester
m-PEG2000-NHS ester (mPEG2000-SC) is a reagent with both cell adhesion inhibition and peptide conjugation functions. The NHS ester group of m-PEG2000-NHS ester forms stable amide bonds with primary amine-containing molecules (e.g., the N-terminus of MMP-2-cleavable octapeptide) to generate mPEG-peptide intermediates for liposome surface modification. When m-PEG2000-NHS ester is immobilized on a cystamine-modified gold surface, it can construct an in vitro model for cell adhesion kinetic studies, and higher PEG density and thicker layers correlate with lower cell adhesion rates. m-PEG2000-NHS ester can synthesize MMP-2-responsive PEGylated lipid conjugates to achieve MMP-triggered dePEGylation in the tumor microenvironment. m-PEG2000-NHS ester can be used in studies related to colon cancer and other conditions .
loading...
    loading...
Cat. No.: HY-153631
CAS No.: 482618-42-8
Research Areas:  

Inflammation/Immunology

Sulfo-TAG NHS ester disodium is an N-hydroxysuccinimide ester that can be coupled to proteins via primary amine groups. Sulfo-TAG NHS ester disodium can be used for antibody labeling .
loading...
    loading...
Cat. No.: HY-140679
CAS No.: 80506-64-5
Purity:  ≥98.0%
Synonyms: mPEG20000-NH2
mPEG20000-amine (mPEG20000-NH2) is a class of functionalized polymers composed of a methoxy-terminated polyethylene glycol backbone and a terminal primary amine group. mPEG20000-amine serves as an important intermediate for constructing functionalized nanocarriers, modifying proteins or polypeptides, and developing novel drug delivery systems.
loading...
    loading...
Cat. No.: HY-130086
CAS No.: 1314378-11-4
Purity:  99.29%
Target:  

ADC Linkers

Research Areas:  

Cancer

Bis-PEG4-NHS ester is a crosslinking reagent and amine-reactive modulator .Bis-PEG4-NHS ester reacts with primary amine groups on liposome surfaces via amide bond formation to covalently attach dibenzylcyclooctyne groups, with a hydrophilic PEG4 spacer reducing steric hindrance for subsequent click chemistry .Bis-PEG4-NHS ester enables site-specific antibody coupling to liposome surfaces via copper-free strain-promoted alkyne-azide cycloaddition click chemistry without disrupting liposome structure in minimal organic solvent volumes .Bis-PEG4-NHS ester undergoes hydrolysis during annealing to form -COOH groups that interact with PbI and FAI to enhance perovskite structural integrity, passivate defects, and modulate nucleation kinetics to regulate crystal growth .Bis-PEG4-NHS ester enhances device efficiency and long-term stability when used as an antisolvent additive for p-i-n perovskite solar cells .
loading...
    loading...
Cat. No.: HY-140676
CAS No.: 80506-64-5
Purity:  99.57%
Synonyms: mPEG2000-NH2
mPEG2000-amine (mPEG2000-NH2) is a class of functionalized polymers composed of a methoxy-terminated polyethylene glycol backbone and a terminal primary amine group. mPEG2000-amine serves as an important intermediate for constructing functionalized nanocarriers, modifying proteins or polypeptides, and developing novel drug delivery systems.
loading...
    loading...
Cat. No.: HY-140677
CAS No.: 80506-64-5
Purity:  ≥98.0%
Synonyms: mPEG5000-NH2
mPEG5000-amine (mPEG5000-NH2) is a class of functionalized polymers composed of a methoxy-terminated polyethylene glycol backbone and a terminal primary amine group. mPEG5000-amine serves as an important intermediate for constructing functionalized nanocarriers, modifying proteins or polypeptides, and developing novel drug delivery systems.
loading...
    loading...
Cat. No.: HY-W040289
CAS No.: 955094-26-5
Target:  

ADC Linkers

Research Areas:  

Cancer

Mal-amido-PEG2-NHS ester is a nonclaevable ADC linker containing a maleimide group and an NHS ester. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules .
loading...
    loading...
Cat. No.: HY-140675
CAS No.: 80506-64-5
Purity:  ≥98.0%
Synonyms: mPEG1000-NH2
mPEG1000-amine (mPEG1000-NH2) is a class of functionalized polymers composed of a methoxy-terminated polyethylene glycol backbone and a terminal primary amine group. mPEG1000-amine serves as an important intermediate for constructing functionalized nanocarriers, modifying proteins or polypeptides, and developing novel drug delivery systems.
loading...
    loading...
Cat. No.: HY-W041994
CAS No.: 80307-12-6
GMBS is a heterobifunctional crosslinker targeting primary amines and sulfhydryl groups. GMBS can be used for chemical crosslinking of proteins and crosslinking mass spectrometry (CXMS) to study protein folding and map interfaces between interacting proteins .
loading...
    loading...
Cat. No.: HY-W087960
CAS No.: 616-24-0
Target:  

Drug Intermediate

Research Areas:  

Others

3-Aminopentane is a monoalkylamine compound containing a primary aliphatic amine group. 3-Aminopentane is a building block in the chemical synthesis .
loading...
    loading...
Cat. No.: HY-155881
CAS No.: 80506-64-5
Purity:  ≥98.0%
Synonyms: mPEG550-NH2
mPEG550-amine (mPEG550-NH2) is a class of functionalized polymers composed of a methoxy-terminated polyethylene glycol backbone and a terminal primary amine group. mPEG550-amine serves as an important intermediate for constructing functionalized nanocarriers, modifying proteins or polypeptides, and developing novel drug delivery systems.
loading...
    loading...
Cat. No.: HY-140663
Purity:  ≥95.0%
Research Areas:  

Cancer

Azide-PEG5000-amine is a class of functionalized polymers composed of a methoxy-terminated polyethylene glycol backbone and a terminal primary amine group. Azide-PEG5000-amine serves as an important intermediate for constructing functionalized nanocarriers, modifying proteins or polypeptides, and developing novel drug delivery systems. Azide-PEG5000-amine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
loading...
    loading...
Cat. No.: HY-W043748
CAS No.: 38862-24-7
Synonyms: N-Succinimidyl acrylate
Research Areas:  

Others

2,5-Dioxopyrrolidin-1-yl acrylate (N-Succinimidyl acrylate) is a lysine residue modifier and coupling monomer. 2,5-Dioxopyrrolidin-1-yl acrylate covalently modifies the primary amines of lysine residues on monoclonal anti-horseradish peroxidase IgG antibodies, neutralizes positive charges and replaces them with low-affinity acrylate groups. 2,5-Dioxopyrrolidin-1-yl acrylate inhibits the formation of rapid hard coronas on citrate-coated gold nanoparticles, induces antibody unfolding and loss of antigen-binding function, but does not affect the antigen-binding function of antibodies in free solution. 2,5-Dioxopyrrolidin-1-yl acrylate reacts with the ε-amino groups on lysine residues of L-asparaginase, introduces vinyl groups and generates N-hydroxysuccinimide. 2,5-Dioxopyrrolidin-1-yl acrylate regulates the activity of L-asparaginase .
loading...
    loading...
Cat. No.: HY-140648
Purity:  ≥95.0%
Research Areas:  

Cancer

Amine-PEG5000-amine is a class of functionalized polymers composed of a methoxy-terminated polyethylene glycol backbone and a terminal primary amine group. Amine-PEG5000-amine serves as an important intermediate for constructing functionalized nanocarriers, modifying proteins or polypeptides, and developing novel drug delivery systems.
loading...
    loading...