Search Result

Results for "

starvation

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ADC Payload (1) Aminopeptidase (1) AMPK (1) Apoptosis (2) Autophagy (6) Bacterial (2) Biochemical Assay Reagents (1) Disulfidptosis (1) Drug Intermediate (1) Elastase (1) Endogenous Metabolite (1) Environmental Pollutants (1) Ferroptosis (2) HIF/HIF Prolyl-Hydroxylase (1) Histone Methyltransferase (1) Isotope-Labeled Compounds (1) Methylenetetrahydrofolate Dehydrogenase (MTHFD) (1) Mitochondrial Metabolism (1) N-myristoyltransferase (1) NADPH Oxidase (1) Neuropeptide Y Receptor (1) Oxidative Phosphorylation (1) Parasite (4) PI3K (3) Reactive Oxygen Species (ROS) (1) Reference Standards (2) Tyrosinase (1) VDAC (1)
By Research Areas:	Cancer (13) Infection (8) Inflammation/Immunology (1) Neurological Disease (6)

By Targets:

ADC Payload (1)

Aminopeptidase (1)

AMPK (1)

Apoptosis (2)

Autophagy (6)

Bacterial (2)

Biochemical Assay Reagents (1)

Disulfidptosis (1)

Drug Intermediate (1)

Elastase (1)

Endogenous Metabolite (1)

Environmental Pollutants (1)

Ferroptosis (2)

HIF/HIF Prolyl-Hydroxylase (1)

Histone Methyltransferase (1)

Isotope-Labeled Compounds (1)

Methylenetetrahydrofolate Dehydrogenase (MTHFD) (1)

Mitochondrial Metabolism (1)

N-myristoyltransferase (1)

NADPH Oxidase (1)

Neuropeptide Y Receptor (1)

Oxidative Phosphorylation (1)

Parasite (4)

PI3K (3)

Reactive Oxygen Species (ROS) (1)

Reference Standards (2)

Tyrosinase (1)

VDAC (1)

By Research Areas:

Cancer (13)

Infection (8)

Inflammation/Immunology (1)

Neurological Disease (6)

Inhibitors & Agonists

Peptides

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-15763

Erastin Maximum Cited Publications 805 Publications Verification	VDAC Ferroptosis Disulfidptosis	Cancer
Erastin is a ferroptosis inducer. Erastin exhibits the mechanism of ferroptosis induction related to ROS and iron-dependent signaling. Erastin inhibits voltage-dependent anion channels (VDAC2/VDAC3) and accelerates oxidation, leading to the accumulation of endogenous reactive oxygen species. Erastin also disrupts mitochondrial permeability transition pore (mPTP) with anti-tumor activity. Furthermore, Erastin can block the uptake of cystine mediated by SLC7A11 and also spares UMRC6-EV and -C91A cells from disulfidptosis under glucose starvation .

HY-12481

SAR405 30+ Cited Publications	PI3K Autophagy	Cancer
SAR405 is a first-in-class, selective, and ATP-competitive PI3K class III (PIK3C3) isoform Vps34 inhibitor (IC₅₀=1.2 nM; K_d=1.5 nM). SAR405 inhibits autophagy induced either by starvation or by mTOR inhibition. Anticancer activity .

HY-101920

Autophinib 10+ Cited Publications	Autophagy PI3K	Neurological Disease Cancer
Autophinib is a potent, selective autophagy inhibitor with IC₅₀s of 90 nM and 40 nM for starvation- and Rapamycin-induced autophagy, respectively. Autophinib is also an ATP competitive Vacuolar Protein Sorting 34 (VPS34) inhibitor with an IC₅₀ of 19 nM. Autophinib inhibits autophagy induced by starvation or Rapamycin by targeting VPS34 .

HY-158742

SBB-Analogue (GL13) Biotin 1 Publications Verification GL13; SBB-A-B	Tyrosinase	Others
SBB-Analogue (GL13) Biotin (GL13; SBB-A-B) consists of a Sudan Black B (SBB) (HY-D0213) derivative conjugated with biotin. SBB-Analogue (GL13) Biotin potently detects senescent cells and eliminates the drawback of false-positive staining caused by serum starvation and cell fusion in SA-β-gal assays. SBB-Analogue (GL13) Biotin can be used in flow cytometry, immunofluorescence analysis, and other applications .

HY-131943

DS44960156	Methylenetetrahydrofolate Dehydrogenase (MTHFD)	Neurological Disease Cancer
DS44960156 is a selective MTHFD2 inhibitor with moderate to low blood-brain barrier penetration (IC₅₀=1.6 μM, K_i=1.23 μM). DS44960156 specifically binds to the active site of MTHFD2, disrupts redox homeostasis and blocks serine-mediated one-carbon metabolism, thereby increasing the NAD ⁺/NADH ratio and ROS levels. DS44960156 not only effectively inhibits the proliferation of glioma cells, but also enhances the sensitivity of cells to glutamine starvation-induced death. DS44960156 binds to plasma proteins, shows no mutagenicity, carcinogenicity or acute oral toxicity, and serves as a research agent for glioblastoma multiforme and other cancers .

HY-119649

Flonicamid IKI220	Environmental Pollutants Parasite	Infection
Flonicamid (IKI220) is a novel systemic insecticide with selective activity against hemipterous pests. The main insecticidal mechanism of flonicamid is starvation based on the inhibition of stylet penetration to plant tissues .

HY-121262

Bisabolene (mixture of isomers) 1 Publications Verification Bisabolene; γ-Bisabolene	Drug Intermediate	Infection
Bisabolene (mixture of isomers) (Bisabolene) is a sesquiterpenoid plant natural product and also a hydrocarbon precursor for various industry-relevant chemicals. Bisabolene (mixture of isomers) serves as an important precursor for the production of industry-relevant chemicals such as biofuels, bioplastics, pharmaceuticals and cosmetics .

HY-128340

Autogramin-2	Autophagy	Cancer
Autogramin-2 potently inhibits autophagy induced by either starvation (IC₅₀=0.27 μM) or mTORC1 inhibition (Rapamycin; IC₅₀=0.14 μM) .

HY-128339

Autogramin-1	Autophagy	Cancer
Autogramin-1 potently inhibits autophagy induced by either starvation (IC₅₀=0.17 μM) or mTORC1 inhibition (Rapamycin; IC₅₀=0.44 μM) .

HY-156694

Hydroxy-PP-Me	Apoptosis NADPH Oxidase Reactive Oxygen Species (ROS)	Inflammation/Immunology Cancer
Hydroxy-PP-Me is a selective CBR1 inhibitor with an IC₅₀ of 759 nM. Hydroxy-PP-Me can inhibit serum starvation-induced apoptosis. Hydroxy-PP-Me can enhance the cytotoxic effects of Daunorubicin (HY-13062A) and As₂O₃ on tumor cells. Hydroxy-PP-Me can be used in the research of cancer such as leukemia .

HY-124726

Aumitin	Autophagy	Neurological Disease Cancer
Aumitin is a diaminopyrimidine-based autophagy inhibitor which inhibits mitochondrial respiration by targeting complex I. Aumitin inhibits starvation- and rapamycin induced autophagy dose dependently with IC₅₀s of 0.12 μM and 0.24 μM, respectively .

HY-116057

Stemazole	Apoptosis	Others
Stemazole is a protective agent that promotes stem cell survival. Stemazole has the protective effect of human embryonic stem cells (hESCs). Stemazole enhances clonal expansion of single cells and decreases apoptosis. Stemazole for the study of stem cell survival in starvation culture .

HY-151344

HIF-1/2α-IN-2	HIF/HIF Prolyl-Hydroxylase	Cancer
HIF-1/2α-IN-2 is an inhibitor of HIF-1/2α. HIF-1/2α-IN-2 decrease HIF-1/2α levels and induces iron starvation response by targeting Iron Sulfur Cluster Assembly 2 (ISCA2) .

HY-162238

OSM-S-106	Parasite	Infection
OSM-S-106 is a pro-inhibitor and that inhibition of PfAsnRS occurs via enzyme-mediated production of an Asn-OSM-S-106 adduct. OSM-S-106 inhibits protein translation and activates the amino acid starvation response. OSM-S-106 exhibits selective activity against Plasmodium blood and liver stages and low intrinsic clearance by human microsomes .

HY-119649S

Flonicamid-15N,18O IKI220-¹⁵N¹⁸O	Isotope-Labeled Compounds Parasite	Infection
Flonicamid- ¹⁵N,18O (IKI220- ¹⁵N,18O) is ¹⁵N labeled Flonicamid. Flonicamid (IKI220) is a novel systemic insecticide with selective activity against hemipterous pests. The main insecticidal mechanism of flonicamid is starvation based on the inhibition of stylet penetration to plant tissues .

HY-P3691

CART (1-39), Human	Neuropeptide Y Receptor	Neurological Disease
CART (1-39), Human, Rat is a neuropeptide consisting of 1-39 residues of the CART peptide. CART (1-39), Human, Rat is a rat satiety factor with potent appetite-suppressing activity and is closely associated with leptin and neuropeptide Y. CART (1-39), Human, Rat inhibits both normal and starvation-induced feeding. CART (1-39), Human, Rat can induce anxiety and stress-related behavior .

HY-119649R

Flonicamid (Standard) IKI220 (Standard)	Parasite Reference Standards	Infection
Flonicamid (Standard) is the analytical standard of Flonicamid. This product is intended for research and analytical applications. Flonicamid (IKI220) is a novel systemic insecticide with selective activity against hemipterous pests. The main insecticidal mechanism of flonicamid is starvation based on the inhibition of stylet penetration to plant tissues .

HY-E70850

NuaK1(ARK5) Recombinant Human Active Protein Kinase	AMPK	Cancer
NuaK1 (ARK5) is a downstream effector of Akt and is activated in response to cellular hypoxia and nutrient starvation. NuaK1(ARK5) Recombinant Human Active Protein Kinase is a recombinant NuaK1(ARK5) protein that can be used to study NuaK1(ARK5)-related functions .

HY-P2025

JMV 236	Histone Methyltransferase	Neurological Disease
JMV 236 is a cholecystokinin antagonist with appetite-suppressing activity. JMV 236 affects the regulation of food intake through the interaction of the intestinal endogenous peptide PrRP and the CCK1 receptor. The administration of JMV 236 activates PrRP neurons located in the NTS, thereby enhancing its appetite-suppressing effect. JMV 236 has significant effects on areas of the central nervous system associated with food intake, especially during states of starvation .

HY-115507A

(Z)-NMac1	Oxidative Phosphorylation Mitochondrial Metabolism	Cancer
(Z)-NMac1 is an Nm23-H1 activator found in Zingiber cassumunar Roxb. (Z)-NMac1 has dual anti-metastatic and anti-proliferative biological activities. (Z)-NMac1 selectively inhibits cancer cell proliferation under glucose starvation conditions by inhibiting mitochondrial complex I activity, leading to ATP depletion and mitochondrial dysfunction. (Z)-NMac1 can be used to study tumors with high oxidative phosphorylation, especially in the glucose-restricted tumor microenvironment .

HY-N18050

Petrobactin	Endogenous Metabolite Bacterial	Infection
Petrobactin is a photoreactive siderophore. Petrobactin can be produced by the oil-degrading marine bacterium Marinobacter hydrocarbonoclasticus. Petrobactin can be synthesized by Bacillus anthracis str. Sterne under conditions of iron starvation. Petrobactin readily undergoes a light-mediated decarboxylation reaction when bound to Fe(III) .

HY-101920R

Autophinib (Standard)	Reference Standards Autophagy PI3K	Neurological Disease Cancer
Autophinib (Standard) is the analytical standard of Autophinib (HY-101920). This product is intended for research and analytical applications. Autophinib is a potent, selective autophagy inhibitor with IC₅₀s of 90 nM and 40 nM for starvation- and Rapamycin-induced autophagy, respectively. Autophinib is also an ATP competitive Vacuolar Protein Sorting 34 (VPS34) inhibitor with an IC₅₀ of 19 nM. Autophinib inhibits autophagy induced by starvation or Rapamycin by targeting VPS34 .

HY-183361

Antibiofilm agent-22	Bacterial Elastase	Infection
Antibiofilm agent-22 is an FpvA receptor-targeting antibacterial agent. Antibiofilm agent-22 chelates iron, disrupts las, pqs, and rhl pathways, reduces elastase, pyocyanin, and rhamnolipid production, and induces bacterial iron starvation. Antibiofilm agent-22 can be used for the research of Pseudomonas aeruginosa infection .

HY-137842

L-Alanine-2-naphthylamide Alanine β-naphthylamide	Aminopeptidase Biochemical Assay Reagents	Others
L-Alanine-2-naphthylamide (Alanine β-naphthylamide) is an Aminopeptidase (E.C. 3.4.11.) substrate and detection reagent. L-Alanine-2-naphthylamide detects the functional activity of aminopeptidase in the intestine of larval whitefish (Coregonus lavaretus). L-Alanine-2-naphthylamide serves as an initiator in the N-carboxyanhydride (NCA) method for synthesizing poly (β-benzyl-L-aspartate) polymers with a terminal 2-naphthyl energy donor group .

HY-P11767

NCR247	Ferroptosis	Infection
NCR247 is a defensin-like nodule cysteine-rich (NCR) peptide and haem sequesterer. NCR247 forms 6:6 haem:NCR247 hexamers and higher-order complexes to render haem and bound iron biologically inaccessible, induces iron-starvation response in Sinorhizobium meliloti and Medicago truncatula, and supports nitrogenase activity.NCR247 is critical for establishing nitrogen-fixing symbiosis between Sinorhizobium meliloti and Medicago truncatula, and is inactive against cytochrome haem.NCR247’s D-enantiomer binds and sequesters haem equivalently to its L-enantiomer.NCR247 can be used for the research of infections, periodontal disease, toxoplasmosis .

HY-183263

MYX1715 analog 1	ADC Payload N-myristoyltransferase	Cancer
MYX1715 analog 1 is an analog of MYX1715 (HY-164285). MYX1715 analog 1 is an N-myristoyltransferase (NMT) inhibitor that inhibits protein myristoylation modification. MYX1715 analog 1 can be conjugated to targeting antibodies via cleavable or non-cleavable linkers for use as an ADC cytotoxin. MYX1715 analog 1 is used in the development of drugs targeting tumor-associated antigens .

Cat. No.	Product Name	Target	Research Area