833481-77-9
833481-77-9
Chemical Structure
Hydroxy-PP-Me
- CAS No.: 833481-77-9
- Formula:C16H18N4O
- Molecular Weight:282.34
InChIKey: CHOWNNXMRTVILJ-UHFFFAOYSA-N
SMILES: OC1=CC=CC(C2=CN(C(C)C)C3=C2C(NC)=NC=N3)=C1
Biological Activity: Hydroxy-PP-Me is a selective CBR1 inhibitor with an IC50 of 759 nM. Hydroxy-PP-Me can inhibit serum starvation-induced apoptosis. Hydroxy-PP-Me can enhance the cytotoxic effects of Daunorubicin (HY-13062A) and As2O3 on tumor cells. Hydroxy-PP-Me can be used in the research of cancer such as leukemia[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Hydroxy-PP-Me | 98.62% | Hydroxy-PP-Me is a selective CBR1 inhibitor with an IC50 of 759 nM. Hydroxy-PP-Me can inhibit serum starvation-induced apoptosis. Hydroxy-PP-Me can enhance the cytotoxic effects of Daunorubicin (HY-13062A) and As2O3 on tumor cells. Hydroxy-PP-Me can be used in the research of cancer such as leukemia. | ||||||||||||||||||||
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References
- [1]. Tanaka M, et al. An unbiased cell morphology-based screen for new, biologically active small molecules. PLoS Biol. 2005 May;3(5):e128. [Content Brief]
- [2]. Jang M, et al. Carbonyl reductase 1 offers a novel therapeutic target to enhance leukemia treatment by arsenic trioxide. Cancer Res. 2012 Aug 15;72(16):4214-24. [Content Brief]
Keywords
