178 Results for "

terminus

" in MedChemExpress (MCE) Product Catalog:
Products (178)

178 Results for "terminus" in MCE Product Catalog:

8
8 Publications Verification
Art. -Nr.: HY-N6666
CAS. Nr.: 24356-66-9
Vidarabine monohydrate is a Purine nucleoside derivative and Antiviral agent. The triphosphate derivative of Vidarabine monohydrate competitively inhibits DNA polymerase, incorporates into the terminus of elongating DNA molecules, and interferes with the early steps of viral DNA synthesis. Vidarabine monohydrate inhibits the replication of herpes simplex virus, varicella-zoster virus, cytomegalovirus, Epstein-Barr virus and vaccinia virus, reduces viral shedding, and accelerates skin healing. Vidarabine monohydrate is metabolized to arabinosyl hypoxanthine, causes minimal impairment of corneal wound healing in rabbit models, and is associated with recurrence of herpes simplex encephalitis. Vidarabine monohydrate can be used in the research of herpetic keratoconjunctivitis, herpes simplex encephalitis, herpetic uveitis, and chronic active hepatitis associated with hepatitis B virus .
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5
5 Cited Publications
Art. -Nr.: HY-P1136
CAS. Nr.: 1507930-57-5
Target:  

Gap Junction Protein

Forschungsgebiete:  

Cardiovascular Disease

Gap19, a peptide derived from nine amino acids of the Cx43 cytoplasmic loop (CL), is a potent and selective connexin 43 (Cx43) hemichannel blocker. Gap19 inhibits hemichannels caused by preventing intramolecular interactions of the C-terminus (CT) with the CL. Gap19 is not blocking GJ channels or Cx40/pannexin-1 hemichannels. Gap19 has protective effects against myocardial .
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5
5 Cited Publications
Art. -Nr.: HY-P1136A
Target:  

Gap Junction Protein

Forschungsgebiete:  

Cardiovascular Disease

Gap19 TFA, a peptide derived from nine amino acids of the Cx43 cytoplasmic loop (CL), is a potent and selective connexin 43 (Cx43) hemichannel blocker. Gap19 TFA inhibits hemichannels caused by preventing intramolecular interactions of the C-terminus (CT) with the CL. Gap19 TFA is not blocking GJ channels or Cx40/pannexin-1 hemichannels. Gap19 TFA has protective effects against myocardial .
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3
3 Cited Publications
Art. -Nr.: HY-150279
CAS. Nr.: 2565638-16-4
Reinheit:  99.65%
Target:  

DNA/RNA Synthesis

Forschungsgebiete:  

Others

PolQi2 is a PolΘ inhibitor that targets and inhibits alt-EJ (alternative end-joining) repair by inhibiting the helicase domain at the N-terminus of PolΘ. PolQi2 enhances the precision and integration efficiency of gene editing at different loci and in various cell lines. Furthermore, the combined use of PolQi2 with DNA-PK inhibitors reduces the off-target effects of Cas9. PolQi2 can be used in gene editing research .
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2
2 Cited Publications
Art. -Nr.: HY-17573
CAS. Nr.: 37025-55-1
Target:  

Oxytocin Receptor

Forschungsgebiete:  

Neurological Disease Endocrinology

Carbetocin, an oxytocin (OT) analogue, is an oxytocin receptor agonist with a Ki of 7.1 nM. Carbetocin has high affinity to chimeric N-terminus (E1) of the oxytocin receptor (Ki=1.17 μM). Carbetocin has the potential for postpartum hemorrhage research. Carbetocin can crosse the blood-brain barrier and produces antidepressant-like activity via activation of oxytocin receptors in the CNS .
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2
2 Cited Publications
Art. -Nr.: HY-16757
CAS. Nr.: 853400-76-7
Synonyms: NNZ-2566
Target:  

iGluR

Forschungsgebiete:  

Neurological Disease

Trofinetide (NNZ-2566), a synthetic analogue of the endogenous N-terminus tripeptide, Glycine-Proline-Glutamate (GPE), has been shown to be neuroprotective in animal models of brain injury.
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2
2 Cited Publications
Art. -Nr.: HY-18619
CAS. Nr.: 36341-25-0
Forschungsgebiete:  

Cancer

YL-109 is an antitumor agent that can induce carboxyl terminus of Hsp70-interacting protein (CHIP) expression through aryl hydrocarbon receptor (AhR) signaling. YL-109 has ability to inhibit breast cancer cell growth and invasiveness .
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2
2 Cited Publications
Art. -Nr.: HY-157508
CAS. Nr.: 3061959-30-3
Reinheit:  99.94%
Target:  

p97

Forschungsgebiete:  

Others

VCP Activator 1 is a VCP activator that dose-dependently stimulates VCP ATPase activity. VCP Activator 1 binds an allosteric pocket near the C-terminus. In addition, VCP Activator 1 binding site can also be occupied by a phenylalanine residue in the VCP C-terminal tail .
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2
2 Cited Publications
Art. -Nr.: HY-P3815
CAS. Nr.: 132176-35-3
Target:  

Casein Kinase

Forschungsgebiete:  

Others

Casein Kinase 2 Substrate Peptide is a common CK2 substrate peptide. Casein Kinase 2 Substrate Peptide is synthesized with its C-terminus conjugated to 5-[(2-aminoethyl)amino]naphthalene-1-sulfonic acid (EDANS). Casein Kinase 2 Substrate Peptide can be used for protein kinase CK2 activity determination .
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2
2 Cited Publications
Art. -Nr.: HY-17573A
CAS. Nr.: 1631754-28-3
Target:  

Oxytocin Receptor

Forschungsgebiete:  

Neurological Disease Endocrinology

Carbetocin acetate, an oxytocin (OT) analogue, is an oxytocin receptor agonist with a Ki of 7.1 nM. Carbetocin acetate has high affinity to chimeric N-terminus (E1) of the oxytocin receptor (Ki=1.17 μM). Carbetocin acetate has the potential for postpartum hemorrhage research. Carbetocin acetate can crosse the blood-brain barrier and produces antidepressant-like activity via activation of oxytocin receptors in the CNS .
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2
2 Cited Publications
Art. -Nr.: HY-P71340
Reinheit:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: E3 Ubiquitin-Protein Ligase CHIP; Antigen NY-CO-7; CLL-Associated Antigen KW-8; Carboxy terminus of Hsp70-Interacting Protein; STIP1 Homology and U Box-Containing Protein 1; STUB1; CHIP
Species:  
Source:  
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1
1 Cited Publications
Art. -Nr.: HY-P0327
CAS. Nr.: 245445-88-9
Target:  

Peptides

Forschungsgebiete:  

Others

T7 Tag Peptide is a protein tag peptide composed of 11 residues from the N-terminus of gp10, the capsid protein of T7 bacteriophage. T7 Tag Peptide can be fused to the N-terminus or C-terminus of proteins such as enhanced green fluorescent protein (EGFP). T7 Tag Peptide is applicable for various immunoassays and affinity purification .
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1
1 Cited Publications
Art. -Nr.: HY-P1505A
Synonyms: Complement 3a (70-77) TFA
Target:  

Complement System

Forschungsgebiete:  

Inflammation/Immunology

C3a (70-77) TFA (Complement 3a (70-77) TFA) is an octapeptide corresponding to the COOH terminus of C3a, exhibits the specificity and 1 to 2% biologic activities of C3a .
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1
1 Cited Publications
Art. -Nr.: HY-P0327A
Target:  

Peptides

Forschungsgebiete:  

Others

T7 Tag Peptide TFA is a protein tag consisting of 11 residues from the N-terminus of the T7 bacteriophage capsid protein gp10. T7 Tag Peptide TFA can be fused to the N-terminus or C-terminus of proteins such as enhanced green fluorescent protein (EGFP). T7 Tag Peptide TFA can be used in various immunoassays and affinity purification .
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1
1 Cited Publications
Art. -Nr.: HY-P2543
CAS. Nr.: 150138-78-6
Neuropeptide Y (3-36) (human, rat) is a neuropeptide Y fragment derived from humans or rats. Neuropeptide Y is an extremely abundant neurotransmitter in central and peripheral neurons, and it participates in the regulation of psychomotor activity, circadian rhythm, feeding behavior and cardiovascular function. Neuropeptide Y (3-36) (human, rat) can serve as a substrate to be sequentially degraded from its N-terminus by AfuS28, and it requires binding to AfuS28 and SedB to be decomposed into amino acids, dipeptides and tripeptides [1] [2].
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1
1 Cited Publications
Art. -Nr.: HY-W591424
CAS. Nr.: 92451-01-9
Synonyms: mPEG2000-SC; mPEG2000-Succinimidyl ester
m-PEG2000-NHS ester (mPEG2000-SC) is a reagent with both cell adhesion inhibition and peptide conjugation functions. The NHS ester group of m-PEG2000-NHS ester forms stable amide bonds with primary amine-containing molecules (e.g., the N-terminus of MMP-2-cleavable octapeptide) to generate mPEG-peptide intermediates for liposome surface modification. When m-PEG2000-NHS ester is immobilized on a cystamine-modified gold surface, it can construct an in vitro model for cell adhesion kinetic studies, and higher PEG density and thicker layers correlate with lower cell adhesion rates. m-PEG2000-NHS ester can synthesize MMP-2-responsive PEGylated lipid conjugates to achieve MMP-triggered dePEGylation in the tumor microenvironment. m-PEG2000-NHS ester can be used in studies related to colon cancer and other conditions .
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Art. -Nr.: HY-133513
CAS. Nr.: 1919794-40-3
Reinheit:  98.15%
Synonyms: (±)-H3L28
Target:  

Drug Derivative

Forschungsgebiete:  

Cancer

(±)-H3RESCA-TFP ((±)-H3L28) is a tetrafluorophenyl ester derivative of restrained complexing agent (RESCA). (±)-H3RESCA-TFP can be used to conjugate the chelator with a biomolecule via amine coupling (e.g., N terminus and/or the ε-amino groups of lysine) .
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Art. -Nr.: HY-131150
CAS. Nr.: 11140-99-1
Reinheit:  ≥99.0%
Ristomycin sulfate is an antibacterial antibiotic and platelet aggregation inducer. Ristomycin sulfate interacts with the D-alanyl-D-alanine terminus of bacterial cell wall precursors to regulate bacterial cell wall synthesis. Ristomycin sulfate induces platelet aggregation in vitro and inhibits the growth of Gram-positive bacteria. Ristomycin sulfate serves as an in vitro diagnostic compound for detecting von Willebrand factor activity. Ristomycin sulfate is applicable to research related to von Willebrand disease and Bernard-Soulier syndrome .
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Art. -Nr.: HY-P10069
CAS. Nr.: 2313534-24-4
Forschungsgebiete:  

Others

Ac-pSar12-OH is a water-soluble polymer of the polysarcosine class and can be used as a linker. Ac-pSar12-OH is a linear polypeptide derivative composed of 12 arginine units. Ac-pSar12-OH N-terminus is modified with an acetyl group, while the C-terminus retains a free hydroxyl group, which can help enhance the stability of the polypeptide .
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Art. -Nr.: HY-W015450
CAS. Nr.: 923-16-0
Synonyms: D-Alanyl-D-alanine; H-D-Ala-D-Ala-OH
D-Ala-D-Ala is a bacterial endogenous metabolite. D-Ala-D-Ala constitutes the terminus of the peptide part of the peptidoglycan monomer unit and is involved in the transpeptidation reaction as the substrate. D-Ala-D-Ala is catalyzed by D-Alanine-D-Alanine ligase .
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