1. Immunology/Inflammation
  2. Complement System
  3. C3a (70-77) TFA

C3a (70-77) TFA (Synonyms: Complement 3a (70-77) (TFA))

Cat. No.: HY-P1505A
Handling Instructions

C3a (70-77) TFA (Complement 3a (70-77) TFA) is an octapeptide corresponding to the COOH terminus of C3a, exhibits the specificity and 1 to 2% biologic activities of C3a.

For research use only. We do not sell to patients.

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C3a (70-77) TFA Chemical Structure

C3a (70-77) TFA Chemical Structure

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Description

C3a (70-77) TFA (Complement 3a (70-77) TFA) is an octapeptide corresponding to the COOH terminus of C3a, exhibits the specificity and 1 to 2% biologic activities of C3a[1][2].

In Vitro

The direct interaction of C3a(70-77) with human mononuclear leukocytes in culture results in a concentration-dependent inhibition of the generation of LIF evoked by mitogens and by the antigen SK-SD[1].
C3a (70-77) induces histamine release and degranulation of rat mast cells, promotes contraction of guinea pig ileal tissue, and enhances vascular permeability in human skin. C3a (70-77) selectively desensitizes ileal smooth muscle to C3a but not to human C5a, a related anaphylatoxin. The cross-desensitization indicates a specific interaction of C3a (70-77) with cellular C3a binding sites[2].

Molecular Weight

937.96

Formula

C₃₇H₆₂F₃N₁₃O₁₂

Sequence

Ala-Ser-His-Leu-Gly-Leu-Ala-Arg

Sequence Shortening

ASHLGLAR

Shipping

Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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C3a (70-77) TFA
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