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vinblastine

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (1) Antibiotic (2) Apoptosis (2) Autophagy (2) Bacterial (2) BCRP (1) Caspase (1) CDK (1) Drug Derivative (1) Drug Metabolite (1) Drug-Linker Conjugates for ADC (2) HCV (1) Heme Oxygenase (HO) (1) Isotope-Labeled Compounds (1) Microtubule/Tubulin (9) Mitochondrial Metabolism (1) nAChR (2) P-glycoprotein (2) PAK (1) Reactive Oxygen Species (ROS) (1) Reference Standards (2)
By Research Areas:	Cancer (15) Infection (3) Metabolic Disease (1)

Inhibitors & Agonists

Peptides

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-13780

Vinblastine sulfate 15+ Cited Publications Vincaleukoblastine sulfate salt	Microtubule/Tubulin nAChR Autophagy	Cancer
Vinblastine sulfate is a cytotoxic alkaloid used against various cancer types. Vinblastine sulfate inhibits the formation of microtubule and suppresses nAChR with an IC₅₀ of 8.9 μM.

HY-14949

Cevipabulin 2 Publications Verification TTI-237	Microtubule/Tubulin	Cancer
Cevipabulin (TTI-237) is an oral, microtubule-active antitumor compound and inhibits the binding of [ ³H] vinblastine to tubulin, with an IC₅₀ of 18-40 nM for cytotoxicity in human tumor cell line .

HY-128902

MC-Val-Cit-PAB-vinblastine 1 Publications Verification	Drug-Linker Conjugates for ADC	Cancer
MC-Val-Cit-PAB-vinblastine is a agent-linker conjugate for ADC with potent antitumor activity by using vinblastine (an microtubule protein inhibitor), linked via the ADC linker MC-Val-Cit-PAB.

HY-A0279A

Pristinamycin IA 1 Publications Verification Mikamycin B; Mikamycin IA	Bacterial Antibiotic	Infection
Pristinamycin IA (Mikamycin B) is a cycle-peptidic macrolactone antibiotic. Pristinamycin IA is a substrate of P-glycoprotein and inhibits its function. Pristinamycin IA is active against StaphyloEoccus and Srreptococcus .

HY-112749

ME-344	Heme Oxygenase (HO) Reactive Oxygen Species (ROS) Mitochondrial Metabolism Microtubule/Tubulin Caspase Apoptosis	Cancer
ME-344 is an Isoflavone. ME-344 increases mitochondrial ROS generation. ME-344 inhibits tubulin polymerization. ME-344 inhibits HO-1 and impacts its mitochondrial translocation. ME-344 induces Apoptosis through Caspase 3 activation. ME-344 synergizes with Vinblastine in leukemia cells. ME-344 displays anti-tumor activity against leukemia and lung tumor. ME-344 can be used in the research of lung cancer, acute myeloid leukemia, and HER2-negative breast cancer .

HY-13780R

Vinblastine sulfate (Standard) Vincaleukoblastine sulfate salt (Standard)	Reference Standards Microtubule/Tubulin Autophagy nAChR	Cancer
Vinblastine (sulfate) (Standard) is the analytical standard of Vinblastine (sulfate). This product is intended for research and analytical applications. Vinblastine sulfate is a cytotoxic alkaloid used against various cancer types. Vinblastine sulfate inhibits the formation of microtubule and suppresses nAChR with an IC₅₀ of 8.9 μM.

HY-16514

Vindesine	Drug Derivative Microtubule/Tubulin	Cancer
Vindesine is a derivative of Vinblastine (HY-13780). Vindesine binds to and stabilizes tubulin . Vindesine inhibits mitosis in cancer cells and prevents the invasion of normal tissues by malignant cells. Vindesine can be used in cancer research .

HY-177021

Tubulin-IN-51	Microtubule/Tubulin Apoptosis	Cancer
Tubulin-IN-51 is an orally available, potent tubulin inhibitor (IC₅₀ = 31 nM). Tubulin-IN-51 promotes tubulin polymerization in vitro and does not compete with Paclitaxel (HY-B0015) for binding. Tubulin-IN-51 inhibits the binding of Vinblastine (HY-13780) to tubulin. Tubulin-IN-51 downregulates the proportion of cells in the G1 phase and induces apoptosis. Tubulin-IN-51 inhibits tumor growth in multiple nude mouse xenograft models .

HY-P10589

Phomopsinamine A	Microtubule/Tubulin	Cancer
Phomopsinamine A is a derivative of Phomopsin A (HY-N6793). Phomopsinamine A is an inhibitor for tubulin polymerization with IC₅₀ of 0.53 μM. Phomopsinamine A inhibits the binding of Vinblastine (HY-13780) to tubulin (IC₅₀ =0.56 μM), promotes the the binding of Colchicine (HY-16569) to tubulin (IC₅₀ =0.32 μM) .

HY-N15081

5-N-Acetylardeemin	Others	Cancer
5-N-Acetylardeemin potentiated the cytotoxicity of the anticancer agent Vinblastine (HY-13780) in multidrug resistant human tumor cells .

HY-A0279AR

Pristinamycin IA (Standard) Mikamycin B (Standard); Mikamycin IA (Standard)	Reference Standards Bacterial Antibiotic	Infection
Pristinamycin IA (Standard) is the analytical standard of Pristinamycin IA. This product is intended for research and analytical applications. Pristinamycin IA (Mikamycin B) is a cycle-peptidic macrolactone antibiotic. Pristinamycin IA is a substrate of P-glycoprotein and inhibits its function. Pristinamycin IA is active against StaphyloEoccus and Srreptococcus[1].

HY-129880

Desacetylvinblastine hydrazide Deacetylvinblastine hydrazide; DAVLBH	Microtubule/Tubulin	Cancer
Desacetylvinblastine hydrazide (Deacetylvinblastine hydrazide; DAVLBH) is an active component of EC145, a folate-targeted drug conjugate. Desacetylvinblastine hydrazide interferes with the formation of the mitotic spindle, and thus inhibits cell division and leads to cell death. Desacetylvinblastine hydrazide exhibits antitumor activity against folate receptor (FR)-positive tumor .

HY-128941

CCK2R Ligand-Linker Conjugates 1	Drug-Linker Conjugates for ADC	Cancer
CCK2R Ligand-Linker Conjugates 1 is a ligand-linker conjugate, which conjugates to the cytotoxic antimicrotubule agents Desacetyl Vinblastine Hydrazide (DAVBH) and Tubulysin B Hydrazide (TubBH) via a hydrophilic peptide linker .

HY-157876

Anticancer agent 191	P-glycoprotein BCRP	Cancer
Anticancer agent 191 (Compound 2) is a derivative of probenecid (HY-B0545). As a cancer cell efflux inhibitor, Anticancer agent 191 is designed to inhibit P-glycoprotein (P-gp), breast cancer resistance protein (BCRP), and/or multiple multidrug resistance proteins (MRPs). Anticancer agent 191 increases the accumulation of vinblastine in cancer cells, which is used for cancer research .

HY-N15297

Isotenulin	P-glycoprotein	Cancer
Isotenulin inhibits the efflux function of P-glycoprotein by stimulation of P-glycoprotein ATPase, thereby overcoming the multidrug resistance (MDR) of cancer cells. Isotenulin exhibits cytotoxicity in multidrug-resistant cancer cell KB-vin and sensitive cancer cell HeLaS3. Isotenulin exhibits synergistic effect with Paclitaxel (HY-B0015), Vinblastine (HY-13780) and Doxorubicin (HY-15142) .

HY-W740505

*Anhydro Vinblastine* Disulfate-d3**	Isotope-Labeled Compounds	Others
Anhydro Vinblastine Disulfate-d₃ is the deuterium labeled Anhydro Vinblastine Disulfate.

HY-121989

cis-Trismethoxy resveratrol (Z)-3,5,4'-Trimethoxystilbene	Microtubule/Tubulin HCV CDK Akt PAK	Infection Metabolic Disease Cancer
cis-Trismethoxy resveratrol ((Z)-3,5,4'-Trimethoxystilbene) is an anti-HCV agent and Tubulin inhibitor, with an IC₅₀ of 4 μM against Tubulin. cis-Trismethoxy resveratrol induces G2/M phase cell cycle arrest, reduces DCLK1, decreases CDK1 levels, blocks phosphorylation of Akt Ser ⁴⁷³, and induces the expression of p21 ^Cip1/Waf1. cis-Trismethoxy resveratrol exhibits anti-tumor and hepatoprotective activities. cis-Trismethoxy resveratrol can be used in studies related to colon adenocarcinoma, hepatocellular carcinoma, hepatitis C, and liver injury .

HY-133005

Desacetylvinblastine 4-Desacetylvinblastine; Desacetylvincaleukoblastine	Drug Metabolite	Cancer
Desacetylvinblastine (4-Desacetylvinblastine) is the major metabolite of Vinblastine (HY-13780) and a cytotoxic agent. When used alone, desacetylvinblastine has poor anti-tumor effects, but it can exert significant anti-tumor activity when in the presence of specific conjugates .

Cat. No.	Product Name	Target	Research Area

HY-P10589

Phomopsinamine A	Microtubule/Tubulin	Cancer
Phomopsinamine A is a derivative of Phomopsin A (HY-N6793). Phomopsinamine A is an inhibitor for tubulin polymerization with IC₅₀ of 0.53 μM. Phomopsinamine A inhibits the binding of Vinblastine (HY-13780) to tubulin (IC₅₀ =0.56 μM), promotes the the binding of Colchicine (HY-16569) to tubulin (IC₅₀ =0.32 μM) .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-13780

Vinblastine sulfate 15+ Cited Publications Vincaleukoblastine sulfate salt	Apocynaceae Alkaloids Classification of Application Fields Plants Disease Research Fields Alkaloid Dimers Catharanthus roseus (L.) G. Don Source Classification Cancer	Microtubule/Tubulin nAChR Autophagy
Vinblastine sulfate is a cytotoxic alkaloid used against various cancer types. Vinblastine sulfate inhibits the formation of microtubule and suppresses nAChR with an IC₅₀ of 8.9 μM.

HY-A0279A

Pristinamycin IA 1 Publications Verification Mikamycin B; Mikamycin IA	Microorganisms Macrolide Antibiotics Classification of Application Fields Antibiotics Cyclopeptides Other Diseases Antibacterial Disease Research Disease Research Fields Source Classification	Bacterial Antibiotic
Pristinamycin IA (Mikamycin B) is a cycle-peptidic macrolactone antibiotic. Pristinamycin IA is a substrate of P-glycoprotein and inhibits its function. Pristinamycin IA is active against StaphyloEoccus and Srreptococcus .

HY-13780R

Vinblastine sulfate (Standard) Vincaleukoblastine sulfate salt (Standard)	Apocynaceae Alkaloids Structural Classification Plants Alkaloid Dimers Catharanthus roseus (L.) G. Don Source Classification	Reference Standards Microtubule/Tubulin Autophagy nAChR
Vinblastine (sulfate) (Standard) is the analytical standard of Vinblastine (sulfate). This product is intended for research and analytical applications. Vinblastine sulfate is a cytotoxic alkaloid used against various cancer types. Vinblastine sulfate inhibits the formation of microtubule and suppresses nAChR with an IC₅₀ of 8.9 μM.

HY-N15081

5-N-Acetylardeemin	Natural Products Microorganisms Source Classification	Others
5-N-Acetylardeemin potentiated the cytotoxicity of the anticancer agent Vinblastine (HY-13780) in multidrug resistant human tumor cells .

HY-A0279AR

Pristinamycin IA (Standard) Mikamycin B (Standard); Mikamycin IA (Standard)	Structural Classification Microorganisms Macrolide Antibiotics Antibiotics Cyclopeptides Antibacterial Disease Research Source Classification	Reference Standards Bacterial Antibiotic
Pristinamycin IA (Standard) is the analytical standard of Pristinamycin IA. This product is intended for research and analytical applications. Pristinamycin IA (Mikamycin B) is a cycle-peptidic macrolactone antibiotic. Pristinamycin IA is a substrate of P-glycoprotein and inhibits its function. Pristinamycin IA is active against StaphyloEoccus and Srreptococcus[1].

HY-N15297

Isotenulin	Terpenoids Sesquiterpenes Plants Compositae Helenium arizonicum S.F.Blake Source Classification	P-glycoprotein
Isotenulin inhibits the efflux function of P-glycoprotein by stimulation of P-glycoprotein ATPase, thereby overcoming the multidrug resistance (MDR) of cancer cells. Isotenulin exhibits cytotoxicity in multidrug-resistant cancer cell KB-vin and sensitive cancer cell HeLaS3. Isotenulin exhibits synergistic effect with Paclitaxel (HY-B0015), Vinblastine (HY-13780) and Doxorubicin (HY-15142) .

Cat. No.	Product Name	Chemical Structure

HY-W740505

*Anhydro Vinblastine* Disulfate-d3**
Anhydro Vinblastine Disulfate-d₃ is the deuterium labeled Anhydro Vinblastine Disulfate.

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vinblastine

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Isotope-Labeled Compounds

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