89085-54-1
Chemical Structure
Phomopsinamine A
- CAS No.: 89085-54-1
- Formula:C32H43ClN6O8
- Molecular Weight:675.17
InChIKey: YFIIICIITZPYSM-OIXMZTBHSA-N
SMILES: ClC1=CC([C@@H]([C@@H]2NC)O)=CC(O[C@@](C)([C@@]([H])(C(N3[C@@]([H])(C=CC3)C(N/C(C(N)=O)=C(C)/CC)=O)=O)NC([C@@H](NC2=O)C(C)=C)=O)CC)=C1O
Biological Activity: Phomopsinamine A is a derivative of Phomopsin A (HY-N6793). Phomopsinamine A is an inhibitor for tubulin polymerization with IC50 of 0.53 μM. Phomopsinamine A inhibits the binding of Vinblastine (HY-13780) to tubulin (IC50 =0.56 μM), promotes the the binding of Colchicine (HY-16569) to tubulin (IC50 =0.32 μM)[1].
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Phomopsinamine A | Phomopsinamine A is a derivative of Phomopsin A (HY-N6793). Phomopsinamine A is an inhibitor for tubulin polymerization with IC50 of 0.53 μM. Phomopsinamine A inhibits the binding of Vinblastine (HY-13780) to tubulin (IC50 =0.56 μM), promotes the the binding of Colchicine (HY-16569) to tubulin (IC50 =0.32 μM). | |||||||||||||||||||||
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Keywords
