2129 Results for "

extract

" in MedChemExpress (MCE) Product Catalog:
Products (2129)

2129 Results for "extract" in MCE Product Catalog:

510
Lipopolysaccharides, from E. coli O55:B5
Lipopolysaccharides, from E. coli O55:B5
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510 Publications Verification
Cat. No.: HY-D1056
Synonyms: LPS, from Escherichia coli (O55:B5)
Category:  

Natural Products Microorganisms Disease Research Fields Inflammation/Immunology

Target:  

Toll-like Receptor (TLR)

Lipopolysaccharides, from E. coli O55:B5 (LPS, from Escherichia coli (O55:B5)) are endotoxins and TLR4 activators extracted from Escherichia coli (E. coli O55:B5) and are classified as S (smooth) type LPS. Lipopolysaccharides, from E. coli O55:B5 possess the typical three-part structure: O-antigen, core oligosaccharide, and lipid A. Lipopolysaccharides, from E. coli O55:B5 activate TLR-4 in immune cells, exhibit high pyrogenicity, and demonstrate dose and serotype specificity. Lipopolysaccharides, from E. coli O55:B5 can be widely used to induce cellular inflammation and establish animal models related to inflammation .
It is recommended to prepare a solution with concentration ≥2 mg/mL. Vortex thoroughly for more than 10 minutes. Due to the adsorption characteristics of LPS, silanized container or low adsorption centrifuge tubes should be used for aliquoting and storage, and mix thoroughly before use.
146
PMSF
PMSF
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146 Cited Publications
Cat. No.: HY-B0496
CAS No.: 329-98-6
Synonyms: Phenylmethylsulfonyl fluoride; Benzylsulfonyl fluoride
Target:  

Cathepsin Ser/Thr Protease

Research Areas:  

Neurological Disease

PMSF (Phenylmethylsulfonyl fluoride) is a nonspecific and irreversible serine proteases inhibitor. PMSF inhibits some thiol proteases, non-protease enzymes, and acetylcholinesterase. PMSF can be used to prepare protein extracts from tissue and cell lysates .
144
Corn oil
Corn oil
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144 Cited Publications
Cat. No.: HY-Y1888
CAS No.: 8001-30-7
Corn oil, extracted from the germ of corn, can be used as a carrier for agent molecules.
72
Triptolide
Triptolide
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72 Cited Publications
Cat. No.: HY-32735
CAS No.: 38748-32-2
Synonyms: PG490
Category:  

Anti-aging Celastraceae Plants Tripterygium wilfordii Hook. f. Biological Pesticide Research Agricultural Research Terpenoids Diterpenoids Disease Research Fields Cancer

Target:  

Environmental Pollutants NF-κB Apoptosis

Triptolide is a diterpenoid triepoxide extracted from the root of Tripterygium wilfordii with immunosuppressive, anti-inflammatory, antiproliferative and antitumour effects. Triptolide is a NF-κB activation inhibitor .
47
Cryptotanshinone
Cryptotanshinone
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47 Cited Publications
Cat. No.: HY-N0174
CAS No.: 35825-57-1
Synonyms: Cryptotanshinon; Tanshinone c
Category:  

Quinones Labiatae Samanea saman (Jacq.) Merr. Plants Disease Research Fields Naphthalene Quinones Cancer

Target:  

STAT Autophagy

Cryptotanshinone is a natural compound extracted from the root of Salvia miltiorrhiza Bunge that shows antitumor activities. Cryptotanshinone inhibits STAT3 with an IC50 of 4.6 μM.
36
Belinostat
Belinostat
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36 Cited Publications
Cat. No.: HY-10225
CAS No.: 866323-14-0
Purity:  99.95%
Synonyms: PXD101; PX105684
Target:  

HDAC Autophagy

Research Areas:  

Cancer

Belinostat (PXD101; PX105684) is a potent HDAC inhibitor with an IC50 of 27 nM in HeLa cell extracts.
29
Puerarin
Puerarin
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29 Cited Publications
Cat. No.: HY-N0145
CAS No.: 3681-99-0
Category:  

Pueraria edulis Pampan. Flavonoids Leguminosae Phenols Polyphenols Plants Disease Research Fields Cancer Isoflavones

Target:  

5-HT Receptor

Puerarin is an isoflavone extracted from Pueraria root and is a 5-HT2C receptor antagonist. Puerarin inhibits the dorsal motor nucleus of the vagus (DMV)-vagus nerve pathway, which in turn leads to decreased fat absorption .
25
Phloretin
Phloretin
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25 Cited Publications
Cat. No.: HY-N0142
CAS No.: 60-82-2
Synonyms: NSC 407292; RJC 02792
Category:  

Rosaceae Plants Dihydrochalcones Endogenous metabolite Human Gut Microbiota Metabolites Flavonoids Microorganisms Malus pumila Mill. Phenols Polyphenols Disease Research Fields Cancer

Target:  

SGLT Endogenous Metabolite GLUT

Phloretin (NSC 407292; RJC 02792) is a flavonoid extracted from Malus pumila Mill.，has anti-inflammatory activities. Phloridzin is a specific，competitive and orally active inhibitor of sodium/glucose cotransporters in the intestine (SGLT1) and kidney (SGLT2). Phloretin inhibits Yeast-made GLUT1 as well as Human erythrocyte GLUT1 with IC50values of 49 μM and 61 μM，respectively .Phloretin has the potential for the treatment of rheumatoid arthritis (RA) and allergic airway inflammation .
25
Phloretin (Standard)
Phloretin (Standard)
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25 Cited Publications
Cat. No.: HY-N0142R
CAS No.: 60-82-2
Synonyms: NSC 407292 (Standard); RJC 02792 (Standard)
Category:  

Human Gut Microbiota Metabolites Flavonoids Malus pumila Mill. Rosaceae Phenols Plants Endogenous metabolite Disease Research Fields Cancer

Target:  

Reference Standards SGLT Endogenous Metabolite GLUT

Phloretin (Standard) is the analytical standard of Phloretin. This product is intended for research and analytical applications. Phloretin (NSC 407292; RJC 02792) is a flavonoid extracted from Malus pumila Mill., has anti-inflammatory activities. Phloridzin is a specific, competitive and orally active inhibitor of sodium/glucose cotransporters in the intestine (SGLT1) and kidney (SGLT2). Phloretin inhibits Yeast-made GLUT1 as well as Human erythrocyte GLUT1 with IC50values of 49 μM and 61 μM, respectively .Phloretin has the potential for the treatment of rheumatoid arthritis (RA) and allergic airway inflammation .
24
Wedelolactone
Wedelolactone
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24 Cited Publications
Cat. No.: HY-N0551
CAS No.: 524-12-9
Category:  

Alysicarpus ovalifolius (Schumacher) J. Leonard Phenols Polyphenols Plants Compositae Disease Research Fields Inflammation/Immunology

Target:  

Caspase Lipoxygenase Apoptosis

Wedelolactone suppresses LPS-induced caspase-11 expression by directly inhibits the IKK Complex. Wedelolactone also inhibits 5-lipoxygenase (5-Lox) with an IC50 of 2.5 μM. Wedelolactone induces caspase-dependent apoptosis in prostate cancer cells via downregulation of PKCε without inhibiting Akt. Wedelolactone can extract from Eclipta alba, and it can be used for the research of cancer .
22
Lycorine
Lycorine
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22 Cited Publications
Cat. No.: HY-N0288
CAS No.: 476-28-8
Category:  

Alkaloids other families Pyrrole Alkaloids Plants Disease Research Fields Isoquinoline Alkaloids Inflammation/Immunology Amaryllidaceae

Target:  

Fatty Acid Synthase (FASN) Virus Protease Bacterial Apoptosis

Lycorine is a natural alkaloid extracted from the Amaryllidaceae plant. Lycorine is a potent and orally active SCAP inhibitor with a Kd value 15.24 nM. Lycorine downregulates the SCAP protein level without changing its transcription . Lycorine is also a melanoma vasculogenic inhibitor . Lycorine can be used for the study of prostate cancer and metabolic diseases .
20
Basement Membrane Matrix
Basement Membrane Matrix
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20 Cited Publications
Cat. No.: HY-K6002

MCE Basement Membrane Matrix is primarily composed of natural basement membrane matrix extracted from mouse tumors.This product is mainly used for studies of tumor invasion, angiogenesis and organoids culture while avoiding color interference in subsequent experiments.

20
Liensinine Diperchlorate
Liensinine Diperchlorate
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20 Cited Publications
Cat. No.: HY-N0485
CAS No.: 5088-90-4
Category:  

Cardiovascular Disease Alkaloids Piperidine Alkaloids Phenols Polyphenols Nelumbo nucifera Gaertn. Plants Disease Research Fields Nymphaeaceae

Target:  

Autophagy Mitophagy

Liensinine Diperchlor​ate is a major isoquinoline alkaloid, extracted from the seed embryo of Nelumbo nucifera Gaertn. Liensinine Diperchlor​ate inhibits late-stage autophagy/mitophagy through blocking autophagosome-lysosome fusion. Liensinine Diperchlor​ate has a wide range of biological activities, including anti-arrhythmias, anti-hypertension, anti-pulmonary fibrosis, relaxation on vascular smooth muscle, etc .
19
Geniposide
Geniposide
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19 Cited Publications
Cat. No.: HY-N0009
CAS No.: 24512-63-8
Category:  

Iridoids Terpenoids Rubiaceae Plants Gardenia jasminoides Ellis

Target:  

Amyloid-β Influenza Virus

Geniposide is an iridoid glucoside extracted from Gardenia jasminoidesEllis fruits; exhibits a varity of biological activities such as anti-diabetic, antioxidative, antiproliferative and neuroprotective activities.
19
Geniposide (Standard)
Geniposide (Standard)
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19 Cited Publications
Cat. No.: HY-N0009R
CAS No.: 24512-63-8
Category:  

Iridoids Terpenoids Rubiaceae Plants Gardenia jasminoides Ellis

Target:  

Reference Standards Amyloid-β Influenza Virus

Geniposide (Standard) is the analytical standard of Geniposide. This product is intended for research and analytical applications. Geniposide is an iridoid glucoside extracted from Gardenia jasminoidesEllis fruits; exhibits a varity of biological activities such as anti-diabetic, antioxidative, antiproliferative and neuroprotective activities.
17
Sinomenine
Sinomenine
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17 Cited Publications
Cat. No.: HY-15122
CAS No.: 115-53-7
Purity:  99.94%
Category:  

Neurological Disease Sinomenium acutum(Thunb．)Rehd．Et Wils． Plants Menispermaceae Alkaloids Piperidine Alkaloids Monophenols Phenols Disease Research Fields Inflammation/Immunology

Target:  

NF-κB Opioid Receptor Autophagy Apoptosis

Sinomenine, an alkaloid extracted from Sinomenium acutum, is a blocker of the NF-κB activation . Sinomenine also is an activator of μ-opioid receptor .
17
Sinomenine hydrochloride
Sinomenine hydrochloride
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17 Cited Publications
Cat. No.: HY-15122A
CAS No.: 6080-33-7
Purity:  99.89%
Synonyms: Cucoline hydrochloride
Category:  

Neurological Disease Sinomenium acutum(Thunb．)Rehd．Et Wils． Plants Menispermaceae Alkaloids Piperidine Alkaloids Monophenols Phenols Disease Research Fields Inflammation/Immunology

Target:  

NF-κB Opioid Receptor Autophagy Apoptosis

Sinomenine hydrochloride (Cucoline hydrochloride), an alkaloid extracted from Sinomenium acutum, is a blocker of the NF-κB activation . Sinomenine also is an activator of μ-opioid receptor .
17
Isorhamnetin
Isorhamnetin
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17 Cited Publications
Cat. No.: HY-N0776
CAS No.: 480-19-3
Synonyms: 3'-Methylquercetin
Category:  

Cardiovascular Disease Flavonols Hippophaë rhamnoides Plants Endogenous metabolite Flavonoids Microorganisms Leguminosae Elaeagnaceae Phenols Polyphenols Disease Research Fields Glycyrrhiza uralensis Fisch. Inflammation/Immunology

Target:  

MEK PI3K Endogenous Metabolite

Isorhamnetin is a flavonoid compound extracted from the Chinese herb Hippophae rhamnoides L.. Isorhamnetin suppresses skin cancer through direct inhibition of MEK1 and PI3K.
17
Allicin
Allicin
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17 Cited Publications
Cat. No.: HY-N0315
CAS No.: 539-86-6
Synonyms: Diallyl thiosulfinate
Category:  

Infection Natural Products Liliaceae Plants Disease Research Fields  A．Sativam L. var．Viviparum Regel

Target:  

Bacterial Antibiotic

Allicin (diallyl thiosulfinate) is isolated from garlic including Diallyl monosulfide, Diallyl disulfide, Diallyl trisulfide, Diallyl tetrasulfide, and Methyl allyl disulphide etc. They accounts for 98% of the extract. Allicin (diallyl thiosulfinate) has highly potent antimicrobial activity, and inhibits growth of a variety of microorganisms, among them antibiotic-resistant strains .
16
Anacardic Acid
Anacardic Acid
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16 Cited Publications
Cat. No.: HY-N2020
CAS No.: 16611-84-0
Synonyms: Hydroginkgolic acid; Ginkgolic Acid C15:0
Category:  

Ginkgoaceae Plants Ginkgo biloba Monophenols Ketones, Aldehydes, Acids Phenols Anacardium occidentaleL. Disease Research Fields Cancer Anacardiaceae

Target:  

Histone Acetyltransferase Epigenetic Reader Domain Bacterial

Anacardic Acid, extracted from cashew nut shell liquid, is a histone acetyltransferase inhibitor, inhibits HAT activity of p300 and PCAF, with IC50s of ∼8.5 μM and ∼5 μM, respectively.
Assay Types