2. Apoptosis
  3. Bcl-2 Family
  4. TMX-2164

TMX-2164 is a potent, irreversible B-cell lymphoma 6 (BCL6) inhibitor with an IC50 value of 152 nM. TMX-2164 displays sustained target engagement and antiproliferative activity in cells.

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TMX-2164

TMX-2164 Estructura química

No. CAS : 2418022-85-0

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TMX-2164 Related Antibodies

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Bcl-2 Bcl-xL Bcl-W Mcl-1 Bfl-1 Bcl-B Bax Bak Bim BNIP3 Bad

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Descripciòn

TMX-2164 is a potent, irreversible B-cell lymphoma 6 (BCL6) inhibitor with an IC50 value of 152 nM. TMX-2164 displays sustained target engagement and antiproliferative activity in cells[1].

IC50 & Target

IC50: 152 nM (BCL6)[1]
Cellular Effect
Cell Line Type Value Description References
Sf9 IC50
152 nM
Compound: TMX-2164
Inhibition FITC-labeled BCoR peptide binding to wild type human BCL6 BTB domain (5 to 129 residues) expressed in baculovirus infected Sf9 cells after 30 mins by TR-FRET assay
Inhibition FITC-labeled BCoR peptide binding to wild type human BCL6 BTB domain (5 to 129 residues) expressed in baculovirus infected Sf9 cells after 30 mins by TR-FRET assay
[PMID: 32551010]
In Vitro

TMX-2164 (5 μM; 30 h; HEK293T-cells) displays sustained target engagement and to prolongs occupancy on BCL6 protein[1].
TMX-2164 (6.2 μM; 1, 3, and 5 d; SU-DHL-4 cells) exhibits single digit micromolar antiproliferative activity in SU-DHL-4 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

TMX-2164 Related Antibodies

Cell Viability Assay[1]

Cell Line: SU-DHL-4 cells
Concentration: 6.2 μM
Incubation Time: 1, 3, and 5 days
Result: Inhibited cell growth with 5 days.
Peso molecular

591.01

Fòrmula

C25H24ClFN6O6S
No. CAS
SMILES

O=C(COC1=CC2=C(N(C)C1=O)C(OC)=CC(NC3=NC(NCC4=CC=CC(S(=O)(F)=O)=C4)=NC=C3Cl)=C2)NC
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.
Referencias
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TMX-2164 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TMX-21642418022-85-0TMX2164TMX 2164Bcl-2 FamilyB-cell lymphoma 6target engagementantiproliferativeanticancerHEK293T-cellsSU-DHL-4 cellsInhibitorinhibitorinhibit

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Nombre del producto:
TMX-2164
Cat. No.:
HY-148281
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