RPE - ribulose-5-phosphate-3-epimerase Gene

Also Known as RPE2-1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 6120

About RPE

Cytogenetic location: 2q34 Genomic coordinates (GRCh38): 2:210,002,638-210,022,260 (from NCBI)

This gene has 16 transcripts (splice variants), 227 orthologues and 1 paralogue. Ubiquitous expression in thyroid (RPKM 5.9), adrenal (RPKM 5.7) and 25 other tissues.

Summary

Enables metal ion binding activity; protein homodimerization activity; and ribulose-phosphate 3-epimerase activity. Involved in carbohydrate metabolic process and pentose-phosphate shunt. Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]

RPE Products (14)

mRNA Protein Name
NM_001278282.2 NP_001265211.1 ribulose-phosphate 3-epimerase isoform 2
NM_001278283.2 NP_001265212.1 ribulose-phosphate 3-epimerase isoform 2
NM_001278285.2 NP_001265214.1 ribulose-phosphate 3-epimerase isoform 3
NM_001278286.2 NP_001265215.1 ribulose-phosphate 3-epimerase isoform 4
NM_001278288.2 NP_001265217.1 ribulose-phosphate 3-epimerase isoform 4
NM_001278289.2 NP_001265218.1 ribulose-phosphate 3-epimerase isoform 5
NM_001318926.2 NP_001305855.1 ribulose-phosphate 3-epimerase isoform 6
NM_001318927.2 NP_001305856.1 ribulose-phosphate 3-epimerase isoform 7
NM_001318928.2 NP_001305857.1 ribulose-phosphate 3-epimerase isoform 8
NM_001318929.2 NP_001305858.1 ribulose-phosphate 3-epimerase isoform 9
NM_001318930.2 NP_001305859.1 ribulose-phosphate 3-epimerase isoform 4
NM_001318931.2 NP_001305860.1 ribulose-phosphate 3-epimerase isoform 4
NM_006916.3 NP_008847.1 ribulose-phosphate 3-epimerase isoform 2
NM_199229.3 NP_954699.1 ribulose-phosphate 3-epimerase isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables D-ribulose-phosphate 3-epimerase activity IDA
IDA: Inferred from direct assay
20923965 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
enables metal ion binding IDA
IDA: Inferred from direct assay
20923965 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
enables protein homodimerization activity IPI
IPI: Inferred from physical interaction
20923965 GOA
Biological Process GO Annotation Evidence References Source
involved in carbohydrate metabolic process IDA
IDA: Inferred from direct assay
20923965 GOA
involved in pentose-phosphate shunt IDA
IDA: Inferred from direct assay
20923965 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RPE Protein Structure

Ribul_P_3_epim

Ribul_P_3_epim: Ribulose-phosphate 3 epimerase family (6 - 203)

  • 0
  • 100
  • 200
  • 228 a.a.
Protein Preferred Names Protein Names

ribulose-phosphate 3-epimerase

RPE Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
RPE Q96AT9 CLU Homo sapiens P10909
Anti Tag CoIP
33961781
Intra
RPE Q96AT9 serB2 Yersinia pestis A0A6B3V8E0
Y2H Pooling
20711500
Intra
RPE Q96AT9 GPX4 Homo sapiens P36969
Anti Tag CoIP
33961781
Intra
RPE Q96AT9 RPE Homo sapiens Q96AT9
Y2H Pooling
16189514
Intra
RPE Q96AT9 PLEKHF2 Homo sapiens Q9H8W4
Validated Y2H
32296183
Intra
RPE Q96AT9 RPE Homo sapiens Q96AT9
Validated Y2H
32296183
Intra
RPE Q96AT9 RPE Homo sapiens Q96AT9
X-Ray Diffraction
20923965
Intra
RPE Q96AT9 RPE Homo sapiens Q96AT9
Y2H Array
25416956
Intra
RPE Q96AT9 APOD Homo sapiens P05090
Anti Tag CoIP
33961781
Intra
RPE Q96AT9 RPE Homo sapiens Q96AT9
Y2H Prey Pooling
32296183
Intra
RPE Q96AT9 GCD7 Saccharomyces cerevisiae P32502
Y2H Array
27107014
Intra
RPE Q96AT9 RPE Homo sapiens Q96AT9
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant RPE Proteins

Cat. No. Product Name Accession Purity
HY-P71264 RPE Protein, Human (His) Q96AT9-1 (M1-R228) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P74592 RPE Protein, Human (HEK293, His) Q96AT9-1/NP_954699.1 (M1-R228) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Myasthenic Syndrome, Congenital, 10

  • Congenital Myasthenic Syndrome 10

  • CMS10

  • Lgm

  • Myasthenia, Limb-Girdle, Familial

  • Myasthenia, Limb-Girdle, Familial, Formerly

  • Lgm, Formerly

  • Congenital Myasthenic Syndrome Type Ib, Formerly

  • Cms1b, Formerly

  • Cms Ib, Formerly

  • Myasthenic Myopathy, Formerly

  • Familial Limb-Girdle Myasthenia

  • Cms1b

  • Cms Ib

  • Congenital Myasthenic Syndrome Type 1b

  • Congenital Myasthenic Syndrome Type Ib

  • Myasthenic Myopathy

  • Myasthenic Syndrome, Congenital, Type 10

  • Congenital Myasthenic Syndrome Ib

  • Myopathy In Myasthenia Gravis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Phase
HY-19720A Emixustat hydrochloride Inhibitor 99.29% Phase 3
HY-101019 Ossirene Inhibitor 98.0% Phase 2
HY-125639 (rac)-AR-13503 Inhibitor 99.08% Phase 1

Pre-clinical Phase

Bioactive Molecules (42)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-134928A Pyridinium bisretinoid A2E TFA ≥90.0% Unkown
HY-D0988 R-Phycoerythrin Inducer / Unkown
HY-N0428 Obacunone Inducer 99.75% Unkown
HY-D1742 DeepRed Nucleus Dye Chemical / Unkown
HY-101293 VU0359595 Inhibitor 98.06% Unkown
HY-12462 WS3 98.70% Unkown
HY-145628 CM398 Ligand 99.85% Unkown
HY-19720 Emixustat 98.00% Yes
HY-162904 BPU17 98.16% Unkown
HY-163684 Zoracopan Inhibitor 99.85% Unkown
HY-P10926A MH42 TFA / Unkown
HY-N11499 Myricetin 3-O-α-L-arabinopyranoside Inhibitor 99.33% Unkown
HY-134928 Pyridinium bisretinoid A2E / Unkown
HY-149325 RPE65-IN-1 Inhibitor ≥98.0% Unkown
HY-P4253A Arginyl-Glutamine TFA Inhibitor 99.22% Unkown
HY-P5169A LVGRQLEEFL (mouse) TFA 98.20% Unkown
HY-D2396 Sulfo SMCC R-phycoerythrin / Unkown
HY-W587784 Norbixin / Unkown
HY-151872 HDAC-IN-48 / Unkown
HY-119059 CU239 Inhibitor / Unkown
HY-175663 EYE-002 Inhibitor / Unkown
HY-175664 EYE-003 Inhibitor / Unkown
HY-D0988A R-Phycoerythrin (concentrated solution) Inducer / Unkown
HY-D0988B R-Phycoerythrin ammonium sulfate precipitate Inducer / Unkown
HY-D3556 R-PE Annexin V / Unkown
HY-D3558 R-PE Streptavidin / Unkown
HY-D3559 APC Streptavidin / Unkown
HY-D3562 Activated RPE-Cy5 / Unkown
HY-D3563 Activated RPE-Cy5.5 / Unkown
HY-D3564 Activated RPE-Cy7 / Unkown
HY-P4253 Arginyl-Glutamine Inhibitor / Unkown
HY-P5169 LVGRQLEEFL (mouse) / Unkown
HY-RS12150 RPE Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS12151 RPE65 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-111159 CP-467688 Inhibitor / Unkown
HY-175184 LSD1-IN-44 Inhibitor / Unkown
HY-175185 MC3935 Inhibitor / Unkown
HY-RS16987 Rpe Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22780 Rpe65 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23430 Rpe Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29294 Rpe65 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W997836 4-Amino-3-hydroxyphenylalanine / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus RPE MGD MGI:1913896
Rattus norvegicus RPE RGD RGD:1564890