2. Autophagy
  3. Autophagy
  4. CP-467688

CP-467688 is an orally active retinotoxic agent. CP-467688 induces increased lysosome volume, phagocytosis inhibition and autophagy inhibition in retinal cells. CP-467688 is applicable to the research of retinopathy.

For research use only. We do not sell to patients.

CP-467688

CP-467688 Chemical Structure

CAS No. : 909576-25-6

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CP-467688 Related Antibodies

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Description

CP-467688 is an orally active retinotoxic agent. CP-467688 induces increased lysosome volume, phagocytosis inhibition and autophagy inhibition in retinal cells. CP-467688 is applicable to the research of retinopathy[1].

In Vitro

CP-467688 (1.2-100.0 mM; 24 h) induces concentration-dependent lysosomal volume expansion in ARPE-19 cells[1].
CP-467688 (1.2-100.0 mM; 24 h) inhibits the phagocytic function of ARPE-19 cells[1].
CP-467688 (1.2-100.0 mM; 24 h) inhibits autophagic flux in ARPE-19 cells, with the peak punctate LC3 fluorescence intensity being approximately 5 times that of the control group[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CP-467688 Related Antibodies

Immunofluorescence[1]

Cell Line: ARPE-19
Concentration: 1.5, 1.2, 3.1, 3.7, 11.1, 33.3, 100.0 mM
Incubation Time: 24 h
Result: Induced a concentration-dependent increase in punctate LC3 fluorescence intensity relative to vehicle control, with peak activity reaching approximately 5-fold greater than control.
Triggered a > 2-fold increase in LC3 intensity at multiple tested concentrations.
In Vivo

CP-467688 (100-500 mg/kg; p.o.; daily; 7-14 days) induces retinal toxicity in male Sprague-Dawley rats, as evidenced by vacuolization and disruption of the RPE layer[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Sprague-Dawley (male)[1]
Dosage: 100 mg/kg; 500 mg/kg
Administration: p.o.; daily; 7-14 days
Result: Induced retinal lesions characterized by disrupted retinal pigmented epithelium (RPE) with multiple, round-to-oval vacuoles of variable size in RPE cytoplasm.
Molecular Weight

533.97

Formula

C27H27ClF3N3O3
CAS No.
SMILES

O=C(OC)NCCN1CC2=C(C=C(NC(C3=CC=CC=C3C4=CC=C(C(F)(F)F)C=C4)=O)C=C2)CC1.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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CP-467688 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CP-467688909576-25-6CP467688CP 467688Autophagyretinal cellsretinal lesionsretinal toxicityARPE-19 cellslysosomal massmale Sprague-Dawley ratsretinopathyphagocytosis inhibitionRPE layerautophagy inhibitionInhibitorinhibitorinhibit

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