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  4. 42-O-(2-Azidoethyl)-Rapamycin

42-O-(2-Azidoethyl)-Rapamycin (Compound 4) is an azide compound that can be used as a drug intermediate to synthesize the derivative of Rapamycin (HY-10219).

For research use only. We do not sell to patients.

42-O-(2-Azidoethyl)-Rapamycin

42-O-(2-Azidoethyl)-Rapamycin Chemical Structure

CAS No. : 159351-89-0

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42-O-(2-Azidoethyl)-Rapamycin Related Antibodies

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Description

42-O-(2-Azidoethyl)-Rapamycin (Compound 4) is an azide compound that can be used as a drug intermediate to synthesize the derivative of Rapamycin (HY-10219)[1].

Molecular Weight

983.24

Formula

C53H82N4O13
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C(N1[C@@](C(O[C@@](CC([C@@H](/C=C(C)\[C@@H](O)[C@H](C([C@@H](C[C@@H](/C=C\C=C\C=C2C)C)C)=O)OC)C)=O)([C@@H](C[C@@H]3CC[C@@H](OCCN=[N+]=[N-])[C@H](OC)C3)C)[H])=O)([H])CCCC1)=O)[C@]4(O)O[C@@](C[C@@H]/2OC)([H])CC[C@H]4C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (101.70 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.0170 mL 5.0852 mL 10.1705 mL
5 mM 0.2034 mL 1.0170 mL 2.0341 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.0170 mL 5.0852 mL 10.1705 mL 25.4261 mL
5 mM 0.2034 mL 1.0170 mL 2.0341 mL 5.0852 mL
10 mM 0.1017 mL 0.5085 mL 1.0170 mL 2.5426 mL
15 mM 0.0678 mL 0.3390 mL 0.6780 mL 1.6951 mL
20 mM 0.0509 mL 0.2543 mL 0.5085 mL 1.2713 mL
25 mM 0.0407 mL 0.2034 mL 0.4068 mL 1.0170 mL
30 mM 0.0339 mL 0.1695 mL 0.3390 mL 0.8475 mL
40 mM 0.0254 mL 0.1271 mL 0.2543 mL 0.6357 mL
50 mM 0.0203 mL 0.1017 mL 0.2034 mL 0.5085 mL
60 mM 0.0170 mL 0.0848 mL 0.1695 mL 0.4238 mL
80 mM 0.0127 mL 0.0636 mL 0.1271 mL 0.3178 mL
100 mM 0.0102 mL 0.0509 mL 0.1017 mL 0.2543 mL
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42-O-(2-Azidoethyl)-Rapamycin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

42-O-(2-Azidoethyl)-Rapamycin159351-89-0Drug IntermediateDrug IintermediateInhibitorinhibitorinhibit

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