1. Anti-infection
    Metabolic Enzyme/Protease
  2. Bacterial
    Fungal
    Parasite
    Endogenous Metabolite
  3. 5,6-Dihydroxyindole

5,6-Dihydroxyindole 

Cat. No.: HY-W018025
Handling Instructions

5,6-Dihydroxyindole, a melanin precursor, has a broad-spectrum antibacterial, antifungal, antiviral, antiparasitic activity. 5,6-Dihydroxyindole has cytotoxic effects and is strongly toxic against various pathogens.

For research use only. We do not sell to patients.

5,6-Dihydroxyindole Chemical Structure

5,6-Dihydroxyindole Chemical Structure

CAS No. : 3131-52-0

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Description

5,6-Dihydroxyindole, a melanin precursor, has a broad-spectrum antibacterial, antifungal, antiviral, antiparasitic activity. 5,6-Dihydroxyindole has cytotoxic effects and is strongly toxic against various pathogens[1].

IC50 & Target[1][2]

Human Endogenous Metabolite

 

In Vitro

5,6-Dihydroxyindole (1, 10, 20, 50, 100 μM; for 4 hours) dose-dependently decreases OD492 values. Pretreatment of Sf9 cells with 1.0 mM 5,6-Dihydroxyindole for 4 hours results in 97% mortality, and LC50 values of 20.3 μM in buffer and 131.8 μM in a culture medium[1].
Preincubation of a baculovirus stock with 1.25 mM 5,6-Dihydroxyindole for 3 hours near fully disables recombinant protein production. The LC50 for lambda bacteriophage and eggs of the wasp Microplitis demolitor are 5.6 and 111.0 μM, respectively[1].
5,6-Dihydroxyindole and its spontaneous oxidation products are also active against viruses and parasitic wasps[1].

Molecular Weight

149.15

Formula

C₈H₇NO₂

CAS No.

3131-52-0

SMILES

OC1=CC2=C(C=C1O)C=CN2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

References
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Keywords:

5,6-DihydroxyindoleBacterialFungalParasiteEndogenous MetabolitemelaninprecursorcytotoxictoxicpathogensInhibitorinhibitorinhibit

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5,6-Dihydroxyindole
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