1. GPCR/G Protein
  2. Glucagon Receptor
  3. Glucagon

Glucagon (Synonyms: Porcine glucagon)

Cat. No.: HY-P0082 Purity: 96.85%
Handling Instructions

Glucagon (Porcine glucagon) is a peptide hormone, produced by pancreatic α-cells. Glucagon stimulates gluconeogenesis. Glucagon decreases the activity of HNF-4. Glucagon increases HNF4α phosphorylation.

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Glucagon Chemical Structure

Glucagon Chemical Structure

CAS No. : 16941-32-5

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1 mg USD 72 In-stock
Estimated Time of Arrival: December 31
5 mg USD 216 In-stock
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10 mg USD 336 In-stock
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25 mg USD 660 In-stock
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50 mg USD 888 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

Glucagon (Porcine glucagon) is a peptide hormone, produced by pancreatic α-cells. Glucagon stimulates gluconeogenesis[1]. Glucagon decreases the activity of HNF-4[2]. Glucagon increases HNF4α phosphorylation[3].

In Vitro

Upon binding to its receptor Gcgr, Glucagon activates cAMP-PKA signaling to stimulate hepatic glucose production (HGP) and cause hyperglycemia[1].
Glucagon stimulates both hepatic kisspeptin1 production and gluconeogenesis[1].
Glucagon (100 nM) represses CYP7A1 mRNA expression in human primary hepatocytes[3].
Glucagon (100 nM) increases phosphorylayion of HNF4α[3].

Western Blot Analysis[3]

Cell Line: Human primary hepatocytes (H1211, HH1215)
Concentration: 100 nM
Incubation Time:
Result: Resulted in a marked increase in the amount of phosphorylated HNF4α.
In Vivo

Low-dose (20 μg/kg) Glucagon increases glycemia and does not stimulate insulin secretion in ambient-fed mice. High-dose (1 mg/kg) Glucagon lowers glycemia compared with PBS control and stimulates insulin secretion in ambient-fed mice[4].

Animal Model: C57BL/6J mice (12- to 24-week-old)[4]
Dosage: 20 μg/kg and 1 mg/kg
Administration: Administered by i.p. injection; 45 minutes
Result: Low-dose (20 μg/kg) increased glycemia and did not stimulate insulin secretion.
High-dose (1 mg/kg) lowered glycemia and stimulated insulin secretion.
Clinical Trial
Molecular Weight

3482.75

Formula

C₁₅₃H₂₂₅N₄₃O₄₉S

CAS No.

16941-32-5

Sequence

His-Ser-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-Ser-Arg-Arg-Ala-Gln-Asp-Phe-Val-Gln-Trp-Leu-Met-Asn-Thr

Sequence Shortening

HSQGTFTSDYSKYLDSRRAQDFVQWLMNT

SMILES

[HSQGTFTSDYSKYLDSRRAQDFVQWLMNT]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Protect from light
Powder -80°C 2 years
  -20°C 1 year
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (14.36 mM; Need ultrasonic)

H2O : 20 mg/mL (5.74 mM; ultrasonic and adjust pH to 2 with HCl)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.2871 mL 1.4356 mL 2.8713 mL
5 mM 0.0574 mL 0.2871 mL 0.5743 mL
10 mM 0.0287 mL 0.1436 mL 0.2871 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: 2.5 mg/mL (0.72 mM); Suspended solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: 2.5 mg/mL (0.72 mM); Precipitated solution; Need ultrasonic

*All of the co-solvents are provided by MCE.
References

Purity: 96.85%

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Keywords:

GlucagonPorcine glucagonGlucagon ReceptorGCGRpeptidehormonepancreatic αgluconeogenesisHNF-4HNF4αInhibitorinhibitorinhibit

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Glucagon
Cat. No.:
HY-P0082
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