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  2. Prostaglandin Receptor
  3. MF498

MF498 

Cat. No.: HY-10794 Purity: 98.90%
Handling Instructions

MF498 is a novel and selective E prostanoid receptor 4 (EP4 receptor) antagonist, displayed strong binding affinity for the EP4 receptor with Ki of 0.7 nM.

For research use only. We do not sell to patients.

MF498 Chemical Structure

MF498 Chemical Structure

CAS No. : 915191-42-3

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 367 In-stock
Estimated Time of Arrival: December 31
1 mg USD 62 In-stock
Estimated Time of Arrival: December 31
5 mg USD 276 In-stock
Estimated Time of Arrival: December 31
10 mg USD 504 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Customer Review

Based on 2 publication(s) in Google Scholar

Top Publications Citing Use of Products

Publications Citing Use of MCE MF498

    MF498 purchased from MCE. Usage Cited in: J Virol. 2018 Sep 26;92(20). pii: e01018-18.

    A549 cells are added with an EP2 or an EP4 inhibitor. After 48 h, cells are subjected to WB with an anti-Axl antibody.
    • Biological Activity

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    Description

    MF498 is a novel and selective E prostanoid receptor 4 (EP4 receptor) antagonist, displayed strong binding affinity for the EP4 receptor with Ki of 0.7 nM. Ki value: 0.7 nM Target: EP4 receptor in vitro: MF498 also displays a relatively good selectivity over other prostanoid receptors, does not compromise the mucosal integrity in the gastrointestinal tract.MF498 inhibits PGE2-stimulated cAMP accumulation in a dose-dependent manner with IC50 values of 1.7 and 17 nM in the absence and presence of 10% serum, respectively. in vivo: MF498 relieves joint inflammation and pain in rodent models of rheumatoid and osteoarthritis. MF498 on inflammation in adjuvant-induced arthritis (AIA), a rat model for rheumatoid arthritis (RA), and joint pain in a guinea pig model of iodoacetate-induced osteoarthritis (OA).

    Molecular Weight

    603.69

    Formula

    C₃₂H₃₃N₃O₇S

    CAS No.

    915191-42-3

    SMILES

    O=C1N(C2=C(C)C=C(CS(NC(CC3=CC=CC=C3OC)=O)(=O)=O)C=C2)CC4=C(OCC)C5=NC=CC=C5C(OCC)=C41

    Shipping

    Room temperature in continental US; may vary elsewhere

    Storage
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 31 mg/mL (51.35 mM)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.6565 mL 8.2824 mL 16.5648 mL
    5 mM 0.3313 mL 1.6565 mL 3.3130 mL
    10 mM 0.1656 mL 0.8282 mL 1.6565 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 2.5 mg/mL (4.14 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

      Solubility: ≥ 2.5 mg/mL (4.14 mM); Clear solution

    • 3.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 2.5 mg/mL (4.14 mM); Clear solution

    *All of the co-solvents are provided by MCE.
    References

    Purity: 98.90%

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    Product Name:
    MF498
    Cat. No.:
    HY-10794
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