1. GPCR/G Protein
    Neuronal Signaling
  2. 5-HT Receptor
    Adrenergic Receptor
    Dopamine Receptor
  3. Pardoprunox

Pardoprunox (Synonyms: SLV-308; DU-126891)

Cat. No.: HY-14958
Handling Instructions

Pardoprunox (SLV-308) is a partial dopamine D2 and D3 receptor partial agonist and a serotonin 5-HT1A receptor agonist, with pEC50s of 8, 9.2, and 6.3, respectively.

For research use only. We do not sell to patients.

Pardoprunox Chemical Structure

Pardoprunox Chemical Structure

CAS No. : 269718-84-5

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Pardoprunox (SLV-308) is a partial dopamine D2 and D3 receptor partial agonist and a serotonin 5-HT1A receptor agonist, with pEC50s of 8, 9.2, and 6.3, respectively[1].

IC50 & Target

5-HT1A Receptor

6.3 (pEC50)

D2 Receptor

8 (pEC50)

D3 Receptor

9.2 (pEC50)

In Vitro

Pardoprunox (SLV-308) acts as a potent but partial D2 receptor agonist (pEC50= 8.0 and pA2=8.4) with an efficacy of 50% on forskolin stimulated cAMP accumulation. At human recombinant dopamine D3 receptors, Pardoprunox acts as a partial agonist in the induction of [(35)S]GTPgammaS binding (intrinsic activity of 67%; pEC50=9.2) and antagonized the dopamine induction of [(35)S]GTPgammaS binding (pA2=9.0). Pardoprunox acts as a full 5-HT1A receptor agonist on forskolin induced cAMP accumulation at cloned human 5-HT1A receptors but with low potency (pEC50=6.3)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight









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PardoprunoxSLV-308 DU-126891SLV308SLV 308DU126891DU 126891DU-1268915-HT ReceptorAdrenergic ReceptorDopamine ReceptorSerotonin Receptor5-hydroxytryptamine ReceptorBeta ReceptorInhibitorinhibitorinhibit

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