DNA Alkylator/Crosslinker Chemical
-
Palifosfamide tromethamine
0 ImagesSynonyms: Isophosphoramide mustard tromethamine; IPM tromethamine; ZIO-201 tromethaminePalifosfamide (tromethamine) is a synthetic alkylating agent with potential antineoplastic activity. As the stabilized active metabolite of ifosfamide, palifosfamide (tromethamine) irreversibly alkylates and crosslinks DNA through GC base pairs. This leads to an inhibition of DNA replication and ultimately cell death. Compared to ifosfamide, palifosfamide (tromethamine) is less toxic.
-
WEHI-150
0 ImagesCat. No.: HY-147740CAS No.: 70492-21-6WEHI-150 is a replica of mitoxantrone, is a portent DNA interstrand crosslink
-
Canfosfamide hydrochloride
0 ImagesCat. No.: HY-16123CAS No.: 439943-59-6Canfosfamide (hydrochloride) is a prodrug that upon activation by glutathione s-transferase P1-1 (GSTP1-1) yields an anticancer alkylating agent and a glutathione derivative.
-
Sarcosinamide chloroethylnitrosourea
0 ImagesCat. No.: HY-101002CAS No.: 81965-43-7Synonyms: SarCNU; SarmustineSarcosinamide chloroethylnitrosourea is an orally active alkylating agent. Sarcosinamide chloroethylnitrosourea can induce apoptosis by promoting DNA alkylation. Sarcosinamide chloroethylnitrosourea can be used in cancer-related research.
