MicroRNA Inhibitor

MicroRNA Inhibitors (40):

Cat. No.	Product Name	Effect	Purity

HY-N0177

Diosgenin	Inhibitor	99.92%
Diosgenin, a steroidal saponin, can inhibit STAT3 signaling pathway. Diosgenin is an exogenous activator of Pdia3/ERp57. Diosgenin inhibits aortic atherosclerosis progression by suppressing macrophage miR-19b expression.

HY-150364B

Farabursen sodium scrambled negative control	Inhibitor
Farabursen sodium scrambled negative control is the sequence scrambled negative control of Farabursen sodium.

HY-185317A

Dimovarsen sodium	Inhibitor
Dimovarsen sodium, an oligonucleotide, is a micro RNA-132 inhibitsor, and can be use for the study of heart failure.

HY-185317

Dimovarsen	Inhibitor
Dimovarsen, an oligonucleotide, is a micro RNA-132 inhibitsor, and can be use for the study of heart failure.

HY-W176171

PU.1-IN-1	Inhibitor	99.72%
PU.1-IN-1 is a potent PU.1 inhibitor with an IC₅₀ of 2 nM. PU.1-IN-1 reduces rMANF-induced miR-223 expression. PU.1-IN-1 exhibits anti-inflammatory properties.

HY-N0686

Pseudoprotodioscin	Inhibitor	99.17%
Pseudoprotodioscin, a furostanoside, inhibits SREBP1/2 and microRNA 33a/b levels and reduces the gene expression regarding the synthesis of cholesterol and triglycerides.

HY-115581A

Thymidine 3',5'-diphosphate tetrasodium	Inhibitor	98.75%
Thymidine 3',5'-diphosphate (Deoxythymidine 3′,5′-diphosphate) tetrasodium is a selective inhibitor of staphylococcal nuclease and tudor domain containing 1 (SND1, the MicroRNA regulatory complex RISC subunit) and [3,5-²H₂] tyrosyl nuclease. Thymidine 3',5'-diphosphate tetrasodium has anti-tumor activity and can also be used as a catalyst in biochemical reactions.

HY-15861

Targapremir-210	Inhibitor	98.20%
Targapremir-210 (TGP-210) is a potent and selective miR-210 (miRNA-210, microRNA-210) inhibitor. Targapremir-210 inhibits pre-miR-210 processing with high binding affinity (K_d~200 nM). Targapremir-210 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-123905

LIN28 inhibitor LI71	Inhibitor	98.67%
LIN28 inhibitor LI71 is a LIN28 inhibitor that effectively inhibits LIN28:let-7 binding (IC₅₀: 7 μM). LIN28 inhibitor LI71 can abolish LIN28-mediated oligouridylation of let-7 precursor (IC₅₀: 27 μM). LIN28 inhibitor LI71 has potential application value in LIN28-driven cancer research. LIN28 inhibitor LI71 inhibits the interaction of cold shock protein of Plasmodium falciparum (PfCoSP) with DNA and α/β tubulin and has an inhibitory effect on Plasmodium falciparum.

HY-N8207

Gypenoside LI	Inhibitor	98.29%
Gypenoside LI, a gypenoside monomer, possesses anti-tumor activity. Gypenoside LI induces cell apoptosis, cell cycle and migration.

HY-153534

microRNA-21-IN-3	Inhibitor	98.68%
microRNA-21-IN-3 (compound 45) can specifically bind to the precursor of oncogenic and pro-inflammatory microRNA-21 with medium nanomolar affinity, reduce cancer cell proliferation and miR-21 levels, and can be used in antitumor research.

HY-15843

MIR96-IN-1	Inhibitor	99.57%
MIR96-IN-1 targets the Drosha site in the miR-96 (miRNA-96, microRNA-96) hairpin precursor, inhibiting its biogenesis, derepressing downstream targets, and triggering apoptosis in breast cancer cells. MIR96-IN-1 binds to RNAs with K_ds of 1.3, 9.4, 3.4, 1.3 and 7.4 μM for RNA1, RNA2, RNA3, RNA4 and RNA5, respectively. MIR96-IN-1 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-151516

microRNA-21-IN-2	Inhibitor	99.45%
microRNA-21-IN-2 is a potential miR-21 inhibitor with an AC₅₀ value of 3.29 μM. microRNA-21-IN-2 can be used for the research of cancer.

HY-130487

miR-21-IN-2	Inhibitor	98.42%
miR-21-IN-2 is a high-affinity miR-21 inhibitor. miR-21-IN-2 binds to the apical loop region of the pre-miR-21 hairpin, inhibits Dicer-mediated processing, and thereby blocks the biosynthesis of mature miR-21. miR-21-IN-2 can be used for the research of microRNA-related diseases.

HY-RI04608

hsa-miR-222-3p inhibitor	Inhibitor	99.81%
hsa-miR-222-3p inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.

HY-19731

SID 3712249	Inhibitor	99.26%
SID 3712249 (MiR-544 Inhibitor 1) is a miR-544 biogenesis inhibitor. SID 3712249 binds directly to the precursor miRNA. SID 3712249 blocks production of the mature microRNA and decreases miR-544, HIF-1α, and ATM transcripts. SID 3712249 can be used in the research of cancers, such as breast cancer.

HY-138647

TGP-377/421	Inhibitor	98.17%
TGP-377/421 (Targapre-miR-377/421) is a potent miR-377 and miR-421 inhibitor that binds a functional site in both miRNAs.

HY-132598

Miravirsen	Inhibitor
Miravirsen (SPC-3649) is a potent miR-122 inhibitor and inhibits the biogenesis of miR-122. Miravirsen is a 15-nucleotide locked nucleic acid-modified phosphorothioate antisense oligonucleotide. Miravirsen inhibits HCV replication. Miravirsen can be used in research of HCV infection.

HY-150364A

Farabursen sodium	Inhibitor
Farabursen sodium (RGLS8429 sodium; RG1015 sodium) is a miR-17 inhibitor. Farabursen sodium inhibits the function of the miR-17 family, relieves the inhibitory effect on miR-17 target genes including PKD1 and PKD2, and increases the level of PC1/2. Farabursen sodium slows the growth of renal cysts, reduces the ratio of kidney weight to body weight, and decreases the cyst index and proliferation index. Farabursen sodium is applicable to research related to autosomal dominant polycystic kidney disease.

HY-132601

Cobomarsen	Inhibitor
Cobomarsen (MRG-106) is an oligonucleotide inhibitor of miR-155. Cobomarsen inhibits multiple gene pathways associated with cell survival (including JAK/STAT, MAPK/ERK and PI3K/AKT). Cobomarsen can be used for the research of B-cell lymphoma.

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