PROTAC Linkers
PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.
The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.
PROTAC Linkers Isoform Specific Products
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PROTAC Linkers Related Products (4098)
Related Products (4098)
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PROTAC Linkers Isoform Comparison
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(R)-Boc-4-NH2-3,3-difluoropiperidin
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7-Bromoheptan-1-amine hydrobromide
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4-(1-(tert-Butoxycarbonyl)azetidin-3-yl)benzoic acid
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tert-Butyl (2-(chlorosulfonyl)ethyl)carbamate
0 ImagesCat. No.: HY-W613493CAS No.: 134019-73-1
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3-(1-((Benzyloxy)carbonyl)piperidin-4-yl)propanoic acid
0 ImagesCat. No.: HY-W024030CAS No.: 63845-33-0
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DBCO-PEG3-Gly
0 ImagesCat. No.: HY-W1130399
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4-Amino-cyclohexanecarboxylic acid methyl ester hydrochloride
0 ImagesCat. No.: HY-W298180CAS No.: 100707-54-8
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2-(4-((tert-Butoxycarbonyl)amino)cyclohexyl)acetic acid
0 ImagesCat. No.: HY-W259625CAS No.: 344933-31-9
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N'-Boc-N-(Gly-Oleoyl)-Lys
0 ImagesCat. No.: HY-141291CAS No.: 2353409-71-7
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Propargyl-(trans)-cyclohexanediamine-Boc
0 ImagesCat. No.: HY-W038812CAS No.: 1313279-47-8
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Methyl 6-(chlorosulfonyl)hexanoate
0 ImagesCat. No.: HY-W198960CAS No.: 1202760-84-6
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Mal-NH-PEG12-CH2CH2COOPFP ester
0 ImagesCat. No.: HY-130864CAS No.: 2136296-33-6
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1,4-Phenylenedimethanamine dihydrochloride
0 ImagesCat. No.: HY-W140538CAS No.: 3057-45-2
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Suberic acid (Standard)
0 ImagesCat. No.: HY-W015300RCAS No.: 505-48-6Synonyms: Octanedioic acid (Standard)Suberic acid (Standard) is the analytical standard of Suberic acid. This product is intended for research and analytical applications. Suberic acid is an orally active crystalline dibasic acid. Suberic acid activates the Akt signaling pathway and regulates the expression of molecules related to the TGF-β and MAPK signaling pathways. Suberic acid inhibits skin dryness.
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Heptacosanedioic Acid
0 ImagesCat. No.: HY-W674306CAS No.: 5638-06-2
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6-Bromohexanoyl Chloride
0 ImagesCat. No.: HY-W540231CAS No.: 22809-37-6
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tert-Butyl (2-((tert-butyldimethylsilyl)oxy)ethyl)carbamate
0 ImagesCat. No.: HY-W068370CAS No.: 203738-69-6
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Sebacic acid monomethyl ester
0 ImagesCat. No.: HY-W150022CAS No.: 818-88-2
