Annexin A Degrader
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(R)-SL18
0 ImagesCat. No.: HY-168951CAS No.: 3023189-40-1(R)-SL18 is an annexin A3 (ANXA3) degrader with a Kd value of 1.15 μM for human ANXA3. (R)-SL18 induces ANXA3 degradation via the ubiquitination pathway, shows poor degradation selectivity among annexin family proteins, and its moderate ANXA3 binding affinity correlates with off-target effects. (R)-SL18 inhibits the proliferation, migration, invasion and colony formation of cancer cells. (R)-SL18 can be used in the research of triple-negative breast cancer.
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ANXA3 degrader 1
0 ImagesCat. No.: HY-168950ANXA3 degrader 1 is a degrader targeting annexin A3 (ANXA3), with DC50 values of 1.32 μM and 3.12 μM in MDA-MB-231 and MDA-MB-468 cells, respectively, and exhibits selective activity against ANXA3 relative to other members of the annexin family. ANXA3 degrader 1 induces selective degradation of ANXA3 via the ubiquitin-proteasome pathway rather than autophagy. ANXA3 degrader 1 can be used for research on triple-negative breast cancer.
