Liposome

Liposomes (NPs typically 100–500 nm in diameter) are fabricated from the self-assembly of phospholipids, which consist of a polar phosphate head group and hydrophobic lipid tails. In aqueous environments, the hydrophobic tails self-orient, resulting in a spherical structure comprised of an aqueous core surrounded by a lipophilic bilayer membrane. Liposomes are both biocompatible and biodegradable (e.g., at certain pH and temperature), which can be controlled by modifying the lipid composition. Furthermore, liposomes are amenable to various modifications that improve their efficacy as drug delivery carriers.

References:

[1]. Almeida B, Nag OK, Rogers KE, Delehanty JB. Recent Progress in Bioconjugation Strategies for Liposome-Mediated Drug Delivery. Molecules. 2020;25(23):5672. Published 2020 Dec 1. [Content Brief]

Liposome Related Products (1007):

By Effects:	Inhibitors (2) Controls (2) Substrate (1) Modulator (1) Chemicals (8)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-154927

DSPE-PEG-Cy5
DSPE-PEG-Cy5 is a fluorescent lipophilic PEG lipid. DSPE-PEG-Cy5 can insert into cell membranes and localize uniformly on them. DSPE-PEG-Cy5 can serve as a fluorescent model molecule to optimize and validate membrane insertion conditions for cell surface functionalization. DSPE-PEG-Cy5 can be used in research on drug delivery, cancer, and other fields.

HY-182099

DSPE-PEG1000-DHLASLWWGTEL
DSPE-PEG1000-DHLASLWWGTEL is a PEG compound which composed of DSPE and a GPC3 targeting peptide DHLASLWWGTEL. The DHLASLWWGTEL peptide partially and specifically binds to GPC3-positive cells, achieving precise targeting. DSPE-PEG1000-DHLASLWWGTEL can be used for drug delivery.

HY-W800791

16:0 Caproylamine PE
16:0 Caproylamine PE is an amide-functionalized lipid with a phosphoethanolamine linked to two palmitic acid tails.

HY-112251S1

D-Lin-MC3-DMA-d₆
D-Lin-MC3-DMA-d₆ is the deuterium labeled D-Lin-MC3-DMA (HY-112251). D-Lin-MC3-DMA, an ionizable cationic lipid, is a potent siRNA delivery vehicle.

HY-182099C

DSPE-PEG5000-DHLASLWWGTEL
DSPE-PEG5000-DHLASLWWGTEL is a PEG compound which composed of DSPE and a GPC3 targeting peptide DHLASLWWGTEL. The DHLASLWWGTEL peptide partially and specifically binds to GPC3-positive cells, achieving precise targeting. DSPE-PEG5000-DHLASLWWGTEL can be used for drug delivery.

HY-172272

DSPE-PEG1000-Mal-Cys-ATWLPPR
DSPE-PEG1000-A7R is a PEG compound which composed of DSPE and a tumor vascular targeting peptide (A7R). A7R exhibits high affinity and specificity for VEGFR-2, which is overexpressed in various tumors.

HY-128395

C20-Dihydrosphingomyelin
C20-Dihydrosphingomyelin (C20-DHSM; DHSM (d18:0/20:0)) is a saturated form of Sphingomyelin (HY-113498). C20-Dihydrosphingomyelin is a secondary component of most cell sphingolipids and its levels significantly decrease after intermittent fasting during Ramadan. C20-Dihydrosphingomyelin can be used for the development of liposome reagents.

HY-172715

DSPE-PEG5000-MPG
DSPE-PEG5000-MPG is a PEG compound which composed of DSPE and a peptide vector (MPG). MPG is derived from both the nuclear localisation sequence (NLS) of SV40 large T antigen and the fusion peptide domain of HIV-1 gp41. MPG could deliver short oligonucleotides into cells efficiently and independently of the endosomal pathway.

HY-143689

18:1 Ethylene Glycol
18:1 Ethylene Glycol is a liposome used to deliver agents.

HY-125529

DMPAC-Chol
DMPAC-Chol (Chol-T) is used for liposome formation. DMPAC-Chol (Chol-T) liposomes exhibits great transfection effciencies.

HY-143209A

DSPE-PEG1000-OH sodium
DSPE-PEG1000-OH (sodium) is an ester product.

HY-172494A

DSPE-PEG3400-iRGD
DSPE-PEG3400-iRGD is a PEG compound which composed of DSPE and an αv-integrins targeting peptide (iRGD). iRGD peptide binds to αv-integrins, and then proteolytically cleaved in the tumor to produce CRGDK/R to interact with neuropilin-1, and has tumor-targeting and tumor-penetrating properties. DSPE-PEG3400-iRGD can be used for drug delivery.

HY-182096

DSPE-PEG1000-MG1
DSPE-PEG1000-MG1 is a PEG compound which composed of DSPE and a MG1 peptide (HY-P11315). MG1 peptide is a M1 Microglia-targeting peptide. MG1 peptide can conjugate to anoparticles, crossing the BBB to precisely M1 microglia recognition and achieving controlled release and specific accumulation of drugs through intelligent molecular switching. DSPE-PEG1000-KTP can be used for drug delivery.

HY-177831

Liposomal Vitamin K2
Liposomal Vitamin K2 is a specialized delivery system that encapsulates vitamin K2 within tiny liposomes. These liposomes act as protective shells, enhancing the absorption and bioavailability of vitamin K2. Vitamin K2 (menaquinone-7) is?a fat-soluble nut

HY-163044

C12-SPM
C12-SPM is a lipid that mediates siRNA delivery. C12-SPM has no significant cytotoxicity and can be used for research on hepatoviral diseases.

HY-172275B

DSPE-PEG5000-pPB
DSPE-PEG5000-pPB is a PEG compound which composed of DSPE and a cyclic oligopeptide (pPB). pPB has a strong binding affinity with PDGFRβ, which is overexpressed on activated hepatic stellate cells (HSC). DSPE-PEG5000-pPB can be used for drug delivery.

HY-W340832

18:1 Biotinyl Cap PE
18:1 Biotinyl Cap PE is a fluorescent lipid, which features a head group that has been altered to include biotinyl cap PE.

HY-172491A

DSPE-PEG3400-ESBP
DSPE-PEG3400-ESBP is a PEG compound which composed of DSPE and a E-selectin-binding peptide (ESBP). As a tumor-targeting peptide, ESBP can specifically recognize and bind to receptors or markers on the surface of tumor cells.

HY-144020

14:0 DAP
14:0 DAP (1,2-dimyristoyl-3-dimethylammonium-propane ) is a cationic lipid that can be used for drug delivery.

HY-P10680

TFE-IDAtp1-LinA
TFE-IDAtp1-LinA is a highly potent amphiphilic carrier, containing a trifluoroethyl-iminodiacetic acid analog of Stp. TFE-IDAtp1-LinA, formed nanoparticles with Cas9 RNP/ssDNA, achieved enhanced green fluorescent protein knockouts with an ED₅₀ of 0.38 nM Cas9/sgRNA ribonucleoproteins (RNP).

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