Phospholipid PL1
Phospholipid PL1 is a phospholipid-derived nanoparticle, can deliver costimulatory receptor mRNA (CD137 or OX40) to T cells. Phospholipid PL1 could induce the activation of various immune cells, including T cells and dendritic cells (DCs) in order to boost antitumor immunity.
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- CAS No.: 2274812-94-9
- Formule: C61H121N2O10P
- Masse moléculaire:1073.59
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
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Activité biologique
Description
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:B16F10 melanoma mouse model and A20 lymphoma mouse model (C57BL/6 mice)[1]
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Dosage:Administration of PL1-CD137 + anti-CD137 Ab; PL1-CD137 (10 µg mRNA/mouse), and anti-CD137 Ab (16 µg/mouse)
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Administration:Intratumoral injection; 6 times every other day; 60 days
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Result:Dramatically decreased the tumor growth rate by 5-fold (18 days after inoculation), and increased the overall survival time in B16F10 melanoma model.
Resulted in a 2-fold decrease in the tumor growth rate (18d after inoculation) in A20 lymphoma model, without significant extension in the overall survival time.
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Animal Model:B16F10 melanoma mouse model and CT26 colon carcinoma mouse model (C57BL/6 mice)[1]
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Dosage:Administration of PL1-OX40 + anti-OX40 Ab; PL1-OX40 (10 µg mRNA/mouse), and anti-OX40 Ab (8 µg/mouse)
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Administration:Intratumoral injection; 6 times every other day; 60 days
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Result:Significantly decreased the tumor growth and prolonged survival in comparison to treatment with PBS and PL1-OX40 + anti-OX40 Ab in both tumor models.
Chemical Information
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CAS No. 2274812-94-9
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Masse moléculaire 1073.59
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Formule C61H121N2O10P
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SMILES
O=C(CCCCCCCCN(CCCN(CCCCCCCCC(OC(CCCCC)CC)=O)CCCCCCCCC(OC(CCCCC)CC)=O)CCCOP(OCC)(OCC)=O)OC(CCCCC)CC
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Phospholipid PL1 Related Classifications
HY-151506 Related Classifications
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