904304-57-0
Chemical Structure
1,2-Dierucoyl-sn-glycero-3-PE
Synonym(s): 1,2-Dierucoyl-sn-3-phosphatidylethanolamine; di22:1-PE;PE(22:1/22:1)
- CAS No.: 904304-57-0
- Formula:C49H94NO8P
- Molecular Weight:856.25
InChIKey: VBZSMBBOZFITID-FRWASNMLSA-N
SMILES: CCCCCCCC/C=C\CCCCCCCCCCCC(O[C@@H](COP(OCCN)(O)=O)COC(CCCCCCCCCCC/C=C\CCCCCCCC)=O)=O
Biological Activity: 1,2-Dierucoyl-sn-glycero-3-PE (1,2-Dierucoyl-sn-3-phosphatidylethanolamine) is a phospholipid that contains erucic acid. 1,2-Dierucoyl-sn-glycero-3-PE can be used in the generation of lipid nanoparticles (LNPs) to deliver mRNA in vivo. 1,2-Dierucoyl-sn-glycero-3-PE can also be used to synthesize numerous PEG-conjugates for liposomes incorporation[1][2][3][4].
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1,2-Dierucoyl-sn-glycero-3-PE | 1,2-Dierucoyl-sn-glycero-3-PE (1,2-Dierucoyl-sn-3-phosphatidylethanolamine) is a phospholipid that contains erucic acid. 1,2-Dierucoyl-sn-glycero-3-PE can be used in the generation of lipid nanoparticles (LNPs) to deliver mRNA in vivo. 1,2-Dierucoyl-sn-glycero-3-PE can also be used to synthesize numerous PEG-conjugates for liposomes incorporation. | |||||||||||||||||||||
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- [1]. Vaidya, A., et al., (2024). Analytical Characterization of Heterogeneities in mRNA-Lipid Nanoparticles Using Sucrose Density Gradient Ultracentrifugation. Analytical chemistry, 96(14), 5570–5579. [Content Brief]
- [2]. Longmuir, K. J., et al., (2006). Effective targeting of liposomes to liver and hepatocytes in vivo by incorporation of a Plasmodium amino acid sequence. Pharmaceutical research, 23(4), 759–769. [Content Brief]
- [3]. Haynes, S. M., et al., (2008). Liposomal polyethyleneglycol and polyethyleneglycol-peptide combinations for active targeting to liver in vivo. Drug delivery, 15(4), 207–217. [Content Brief]
- [4]. Tsai, M. S., et al., (2011). Binding patterns of peptide-containing liposomes in liver and spleen of developing mice: comparison with heparan sulfate immunoreactivity. Journal of drug targeting, 19(7), 506–515. [Content Brief]
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