Liposome

Liposomes (NPs typically 100–500 nm in diameter) are fabricated from the self-assembly of phospholipids, which consist of a polar phosphate head group and hydrophobic lipid tails. In aqueous environments, the hydrophobic tails self-orient, resulting in a spherical structure comprised of an aqueous core surrounded by a lipophilic bilayer membrane. Liposomes are both biocompatible and biodegradable (e.g., at certain pH and temperature), which can be controlled by modifying the lipid composition. Furthermore, liposomes are amenable to various modifications that improve their efficacy as drug delivery carriers.

References:

[1]. Almeida B, Nag OK, Rogers KE, Delehanty JB. Recent Progress in Bioconjugation Strategies for Liposome-Mediated Drug Delivery. Molecules. 2020;25(23):5672. Published 2020 Dec 1. [Content Brief]

Liposome Related Products (1007):

By Effects:	Inhibitors (2) Controls (2) Substrate (1) Modulator (1) Chemicals (8)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-160576

DNCA
DNCA is a neutral lipid that can be used in the generation of lipid nanoparticles (LNPs). DNCA can be used in nucleic acid delivery.

HY-W441009E

DSPE-PEG20000-Maleimide ammonium
DSPE-PEG20000-Maleimide ammonium has DSPE phospholipid and maleimide to prepare nanostructured lipid carrier. DSPE-PEG20000-Maleimide ammonium can be used in drug delivery research.

HY-144013C

18:0 mPEG750 PE ammonium
18:0 mPEG750 PE (ammonium) is a PEG lipid functional end group used in the synthesis of liposomes (LPs) for the design of conjugated polymeric nanoparticles. Through biotin modification and carboxyl terminus, lipid nanoparticles (LNPs) further coupling with other biomolecules can be achieved. Functionalized nanoparticles can be used for targeted labeling of specific cellular proteins. With streptavidin as a linker, biotinylated PEG lipid-conjugated polymer nanoparticles are able to bind to biotinylated antibodies on cell surface receptors, yielding the utility of fluorescence-based imaging and sensing.

HY-N0322GL

Cholesterol (GMP Like)
Cholesterol (GMP Like) is Cholesterol (HY-N0322) produced by using GMP like guidelines. GMP Like small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Cholesterol is the major sterol in mammals. It is making up 20-25% of structural component of the plasma membrane. Plasma membranes are highly permeable to water but relatively impermeable to ions and protons. Cholesterol plays an important role in determining the fluidity and permeability characteristics of the membrane as well as the function of both the transporters and signaling proteins. Cholesterol is also an endogenous estrogen-related receptor α (ERRα) agonist.

HY-W800795

18:1 Dodecanyl PE
18:1 Dodecanyl PE is a carboxylic acid-functionalized lipid with a ten carbon linker to a phosphoethanolamine bound to two oleic acid tails.

HY-182101C

DSPE-PEG5000-VHPKQHRGGSKGC
DSPE-PEG5000-VHPKQHRGGSKGC is a targeted modified phospholipid-polyethylene glycol conjugate covalently coupled to DSPE, PEG, and the vascular-targeting peptide VHPKQHRGGSKGC. DSPE-PEG5000-VHPKQHRGGSKGC can be used in research on tumor vascular imaging and vascular-targeted drug delivery.

HY-172705A

DSPE-PEG3400-RVG29
DSPE-PEG3400-RVG29 is a PEG conjugate composed of DSPE and rabies virus glycoprotein 29 (RVG29). RVG29 specifically binds to nicotinic acetylcholine receptors (nAChR) at the blood-brain barrier (BBB), crosses the BBB, and mediates receptor-dependent transcytosis. DSPE-PEG3400-RVG29 can be used for brain-targeted drug delivery, surface modification of nanocarriers, as well as gene and nucleic acid delivery. DSPE-PEG3400-RVG29 is applicable to research related to hypoxic-ischemic brain injury, Parkinson's disease, and other conditions

HY-182092B

DSPE-PEG2000-Asp6
DSPE-PEG2000-Asp6 is a PEG compound which composed of DSPE and a Asp6 peptide. DSPE-PEG2000-Asp6 achieves bone-targeted delivery of drugs or imaging agents by binding to bone tissue with the Asp6 peptide through high affinity.

HY-177844

Liposomal Palmitoylethanolamide
Liposomal Palmitoylethanolamide is a specialized delivery system that encapsulates palmitoylethanolamide within tiny liposomes. These liposomes act as protective shells, enhancing the absorption and bioavailability of palmitoylethanolamide. Palmitoylethan

HY-W800788

18:1 MPB PE
18:1 MPB PE is a maleimide-functionalized thiol-reactive lipid with a phosphoethanolamine linked to two oleic acid tails and a phenyl maleimide group.

HY-148701

mono-Pal-MTO
mono-Pal-MTO is a palm oil-based lipid produced by combining the anticancer agent mitoxantrone (MTO) with palmitoleic acid. When nanoparticles of mono-Pal-MTO and di-Pal-MTO are combined in a molar ratio of 1:1, they show effective siRNA cell delivery and enhance anticancer activity.

HY-147207E

Phospholipid-PEG20000-Biotin
Phospholipid-PEG20000-Biotin is a phospholipid PEG derivative that has a biotin and a phospholipid bridged by a linear PEG linker. Phospholipid-PEG20000-Biotin can interact with avidinylated antibodies. Phospholipid-PEG20000-Biotin can be used to modify liposome and cells surface, and pancreatic islets for cell transplantation.

HY-W1130429

4A3-SC10	Inhibitor
4A3-SC10 is an ionizable cationic lipid (pK_a = 6.57) that has been used in the generation of lipid nanoparticles (LNPs) for the delivery of mRNA. 4A3-SC10 can be used for drug delivery in cancer.

HY-172275C

DSPE-PEG3400-pPB
DSPE-PEG3400-pPB is a PEG compound which composed of DSPE and a cyclic oligopeptide (pPB). pPB has a strong binding affinity with PDGFRβ, which is overexpressed on activated hepatic stellate cells (HSC). DSPE-PEG3400-pPB can be used for drug delivery.

HY-129990

Dios-Arg diTFA
Dios-Arg diTFA, a cationic lipid with an arginine-bearing headgroup, shows obvious double bond proton signals at around 5.2-5.3 ppm. Dios-Arg diTFA is used, coupled to DOPE, to bind siRNA and plasmid to for cationic LNPs for intracellular transport.

HY-172490

DSPE-PEG1000-ESBP
DSPE-PEG1000-ESBP is a PEG compound which composed of DSPE and a E-selectin-binding peptide (ESBP). As a tumor-targeting peptide, ESBP can specifically recognize and bind to receptors or markers on the surface of tumor cells.

HY-172693

DSPE-PEG2000-TH
DSPE-PEG2000-TH is a PEG compound which composed of DSPE and a pH-responsive cell penetrating peptide (TH). TH is activated in an acidic environment (such as the tumor microenvironment) and can selectively carry small molecules, oligonucleotides, proteins, etc. into tumor cells.

HY-172707

DSPE-PEG1000-PP1
DSPE-PEG1000-PP1 is a PEG compound which composed of DSPE and a PP1 peptide. PP1 peptide targets the inflammatory atherosclerotic plaque. DSPE-PEG1000-PP1 can be used for drug delivery.

HY-172500A

DSPE-PEG3400-Mal-CLPLIPTHIISFS
DSPE-PEG3400-Mal-CLPLIPTHIISFS is a PEG compound composed of DSPE and the liver cancer targeting peptide SP94 (HY-P11050A) (sequence SFSIIHTPILPL). SP94 exhibits specific binding to hepatocellular carcinoma (HCC) cells. DSPE-PEG3400-Mal-CLPLIPTHIISFS can be used to prepare lipid nanoparticles to form liver cancer-targeting nanocarriers.

HY-172272C

DSPE-PEG3400-A7R
DSPE-PEG3400-A7R is a PEG compound which composed of DSPE and a tumor vascular targeting peptide (A7R). A7R exhibits high affinity and specificity for VEGFR-2, which is overexpressed in various tumors.

Name
Email *

	Sorry, but the email address you supplied was invalid.