2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Phosphoglycerate Dehydrogenase (PHGDH)
  5. Phosphoglycerate Dehydrogenase (PHGDH) Degrader

Phosphoglycerate Dehydrogenase (PHGDH) Degrader

Phosphoglycerate Dehydrogenase (PHGDH) Degrader (1):

Cat. No. Product Name Effect Purity
  • HY-177742
    LXH-3-71
    		Degrader
    LXH-3-71 is a PHGDH degrader. LXH-3-71 acts as a molecular glue to enhance the interaction of the PHGDH-DDB1-CRL E3 ligase complex, triggering ubiquitination and proteasomal degradation of PHGDH. LXH-3-71 regulates the stemness of colorectal cancer cells and inhibits tumor proliferation and colony formation. LXH-3-71 can be used in the research of colorectal cancer.