2251753-65-6
2251753-65-6
Chemical Structure
LXH-3-71
- CAS No.: 2251753-65-6
- Formula:C41H59N3O4
- Molecular Weight:657.92
InChIKey: KHAFPBAKIVPZNQ-RRBGEOAMSA-N
SMILES: C=C1C[C@]2([C@@](C(C)(C)C1=O)([H])CC[C@]3(C)[C@]2([H])CC=C4[C@]5([H])CC(C)(CC[C@@]5(CC[C@]43C)C(NCCNC(NC6=CC=C(C=C6)OC)=O)=O)C)C
Biological Activity: LXH-3-71 is a PHGDH degrader. LXH-3-71 acts as a molecular glue to enhance the interaction of the PHGDH-DDB1-CRL E3 ligase complex, triggering ubiquitination and proteasomal degradation of PHGDH. LXH-3-71 regulates the stemness of colorectal cancer cells and inhibits tumor proliferation and colony formation. LXH-3-71 can be used in the research of colorectal cancer[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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LXH-3-71 | 97.19% | LXH-3-71 is a PHGDH degrader. LXH-3-71 acts as a molecular glue to enhance the interaction of the PHGDH-DDB1-CRL E3 ligase complex, triggering ubiquitination and proteasomal degradation of PHGDH. LXH-3-71 regulates the stemness of colorectal cancer cells and inhibits tumor proliferation and colony formation. LXH-3-71 can be used in the research of colorectal cancer. | ||||||||||||||||||||
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